ANXA2 and CD99

Number of citations: 0 (PubMedID 15388255)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		ANXA2	CD99
Name		annexin A2	CD99 molecule (Xg blood group)
Structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Basement Membrane Extracellular Space Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Lipid Droplet Cytosol Plasma Membrane Adherens Junction Cell Surface Vesicle Membrane Membrane Basolateral Plasma Membrane Nuclear Matrix Midbody Extracellular Matrix Late Endosome Membrane Vesicle Azurophil Granule Lumen Myelin Sheath Adaxonal Region Sarcolemma Melanosome Schmidt-Lanterman Incisure Membrane Raft Extracellular Exosome RNA Polymerase II Transcription Regulator Complex Plasma Membrane Protein Complex AnxA2-p11 Complex PCSK9-AnxA2 Complex	Cytoplasm Plasma Membrane Focal Adhesion Membrane
	Molecular Function	Phosphatidylserine Binding Protease Binding RNA Binding Phospholipase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phospholipase A2 Inhibitor Activity Identical Protein Binding S100 Protein Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Protein Binding
	Biological Process	Angiogenesis Membrane Raft Assembly Positive Regulation Of Receptor Recycling Negative Regulation Of Receptor Internalization Vesicle Budding From Membrane Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Plasminogen Activation Response To Activity Collagen Fibril Organization Lung Development Positive Regulation Of Vesicle Fusion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Osteoclast Development Fibrinolysis MRNA Transcription By RNA Polymerase II Positive Regulation Of Vacuole Organization Positive Regulation Of Exocytosis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Cell-cell Adhesion Epithelial Cell Apoptotic Process Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Plasma Membrane Repair	Cell Adhesion Homotypic Cell-cell Adhesion T Cell Extravasation Positive Regulation Of Neutrophil Extravasation
Pathways		Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Pancreatic Ductal Cells	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall
Drugs		Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol	None
GWAS		Asthma ( 31959851 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Blood protein levels ( 30072576 ) Night sleep phenotypes ( 27126917 ) Type 2 diabetes ( 25102180 )	No GWAS studies recorded
Interacting Genes		51 interacting genes: ACTA1 APOH APP CCDC32 CD99 CDC42 CEACAM1 CTSB CTSS DYSF EIF4ENIF1 FNDC3B FOXP1 GRB2 HMGA1 LGALS13 LINC00941 LINC01554 LYPLA1 MAP3K4 MYOC NOD2 OGDH PHB1 PLA1A PLA2G4A PLAT PLG POT1 PRKCA PRKCB PTEN RPS2 S100A10 S100A4 S100A6 SLC26A4-AS1 SMN1 SNCA SNX17 SOS1 SRC STAT6 TENT2 TERF1 TERT TNC TRPV5 WEE2-AS1 YWHAQ ZBTB4	12 interacting genes: ANXA2 ENTR1 FTH1 KPNB1 MTNR1A MTNR1B PPIA SGTA TRIP13 UBE2H UBQLN1 UBQLN4
Entrez ID		302	4267
HPRD ID		01061	02434
Ensembl ID		ENSG00000182718	ENSG00000002586
Uniprot IDs		A0A024R5Z7 H0YL33 P07355	A0A096LP69 P14209
PDB IDs		1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH 5LPU 5LPX 5LQ0 5LQ2 5N7D 5N7F 5N7G 6TWQ 6TWU 6TWX 6TWY 7DTO 7EQ7 7NMI 7P70 7P71 7P72 7P73 7P74 7PC3 7PC4 7PC5 7PC7 7PC8 7PC9 7PCB 7QQL 7QQM 7QQN 7ZVN 7ZVX 8AEL	7SFX
GO Terms Enriched among Interactors		Regulation Of Vesicle-mediated Transport Extracellular Exosome Regulation Of Cell Population Proliferation Enzyme Binding Regulation Of Locomotion Negative Regulation Of Wound Healing Regulation Of Transport Nuclear Telomere Cap Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Migration Positive Regulation Of Metabolic Process Negative Regulation Of Fibrinolysis Leukocyte Activation Regulation Of Cell Motility Positive Regulation Of Immune System Process Histone H3T6 Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Cell Junction Assembly Regulation Of Fibrinolysis Negative Regulation Of Coagulation Regulation Of Cell Activation Positive Regulation Of Organelle Organization Regulation Of Immune Response Cell Activation Regulation Of Cell Adhesion Regulation Of MAPK Cascade Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Immune Response Phosphatidylcholine Lysophospholipase Activity Extracellular Matrix Identical Protein Binding Macrophage Activation Positive Regulation Of Cell Migration Regulation Of Endocytosis Negative Regulation Of Cell-substrate Adhesion Telomere Maintenance Via Telomerase Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Myeloid Leukocyte Activation Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Regulation Of Focal Adhesion Assembly Trans-synaptic Signaling By BDNF Protein Kinase C Signaling	Melatonin Receptor Activity Autophagosome Regulation Of Protein Catabolic Process Regulation Of Proteolysis Ficolin-1-rich Granule Lumen Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Cellular Response To Stress Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Identical Protein Binding G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport AnxA2-p11 Complex PCSK9-AnxA2 Complex Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Intracellular Cholesterol Transport Ferritin Complex Ferroxidase Activity Iron Ion Sequestering Activity Protein-containing Complex Cell Adhesion Molecule Production Protein Peptidyl-prolyl Isomerization Negative Regulation Of Protein K48-linked Ubiquitination TRC Complex Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Proteolysis Involved In Protein Catabolic Process Meiotic Recombination Checkpoint Signaling Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Positive Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Transport Positive Regulation Of Plasma Membrane Repair Positive Regulation Of Intracellular Lipid Transport Regulation Of Protein Metabolic Process Mitotic Chromosome Movement Towards Spindle Pole Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep BAT3 Complex Binding Positive Regulation Of Proteasomal Protein Catabolic Process