H1-0 and IPO5

Number of citations: 63 (PubMedID 10228156)
Data Source: HPRD (in vitro)

		H1-0	IPO5
Name		H1.0 linker histone	importin 5
Structure
GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Golgi Apparatus Actin Cytoskeleton Nuclear Body Transcription Repressor Complex	Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Membrane Nuclear Membrane
	Molecular Function	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosome Binding Nucleosomal DNA Binding	RNA Binding GTPase Inhibitor Activity Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Nucleosome Assembly Chromosome Condensation Heterochromatin Formation Negative Regulation Of DNA Recombination Positive Regulation Of Transcription Regulatory Region DNA Binding	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Cell Cycle Cellular Response To Amino Acid Stimulus
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	vRNP Assembly
GWAS		No GWAS studies recorded	Peripheral artery disease ( 26488411 ) Smooth-surface caries ( 24556642 )
Interacting Genes		20 interacting genes: APP CCNE1 CDK1 CDK2 CDK4 CDK5 FBXO7 GRB2 HPF1 IKBKG IPO5 IPO7 KPNA2 KPNB1 NEDD4L NOA1 PARP2 PRKCB RAD51B XBP1	31 interacting genes: ACD CAB39 CDC42 DPPA3 DTNBP1 GPRASP3 H1-0 NOSIP NRIP1 NUP153 NUP214 NUP62 NUP98 OGT PRRC2B PTEN RAG2 RAN RANBP2 RNF10 RPL13 RPL23 RPL23A RPL5 RPL7 RPS7 SRP19 SUMO2 TERF1 TINF2 WASL
Entrez ID		3005	3843
HPRD ID		00819	03597
Ensembl ID		ENSG00000189060	ENSG00000065150
Uniprot IDs		P07305	B3KWG6 O00410 Q9BVS9
PDB IDs		6HQ1 6LA2 6LA8 6LA9 6LAB 6N88 6N89 7COW 7DBP 7K5X 7XVL 7XX6 8TB9 9IPU	6XTE 6XU2 9IM6
GO Terms Enriched among Interactors		Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Regulation Of Protein Localization To Nucleus Cytosol Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Positive Regulation Of Establishment Of Protein Localization Nucleus Nuclear Import Signal Receptor Activity Regulation Of Mitotic Cell Cycle Phase Transition Nuclear Localization Sequence Binding G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition NLS-bearing Protein Import Into Nucleus Apoptotic Process Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Nucleus Programmed Cell Death Cell Death Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Cyclin Binding Ribosomal Protein Import Into Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Phase Transition Regulation Of Nucleocytoplasmic Transport Intracellular Protein Localization Regulation Of Cell Cycle G2/M Phase Transition Protein Import Into Nucleus DNA Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Protein Import Into Nucleus Import Into Nucleus DNA Damage Response Histone Kinase Activity Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Protein Transport	Cytosolic Ribosome Import Into Nucleus Protein Import Into Nucleus Cytoplasmic Translation Establishment Of Protein Localization To Organelle Nuclear Pore Nucleus Ribonucleoprotein Complex Protein Localization To Nucleus Cytosolic Large Ribosomal Subunit Structural Constituent Of Nuclear Pore RNA Binding Protein Localization To Organelle Nuclear Export Shelterin Complex Nuclear Transport Nucleocytoplasmic Transport RNA Transport Structural Constituent Of Ribosome RNA Export From Nucleus Nucleolus Negative Regulation Of Ubiquitin Protein Ligase Activity Nuclear Telomere Cap Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Nucleoplasm Ribosome Nuclear Inclusion Body Ubiquitin Ligase Inhibitor Activity Telomere Capping Nuclear Pore Nuclear Basket Nucleobase-containing Compound Transport Nuclear Envelope Translation MRNA Transport Intracellular Transport Intracellular Protein Transport Dendritic Spine Morphogenesis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Localization Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear Localization Sequence Binding Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Organelle Localization Nuclear Pore Cytoplasmic Filaments Negative Regulation Of RNA Export From Nucleus Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening