UBQLN1 and SCG2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		UBQLN1	SCG2
Name		ubiquilin 1	secretogranin II
Structure			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Aggresome Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Dense Core Granule Neuronal Dense Core Vesicle
	Molecular Function	Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding	Cytokine Activity Protein Binding Chemoattractant Activity
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Autophagy Macroautophagy Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Endoplasmic Reticulum Stress Aggrephagy ERAD Pathway Negative Regulation Of Transport Cellular Response To Hypoxia Autophagosome Maturation Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ERAD Pathway	MAPK Cascade Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response Protein Secretion Intracellular Signal Transduction Endothelial Cell Migration Eosinophil Chemotaxis Positive Chemotaxis Induction Of Positive Chemotaxis Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Cargo recognition for clathrin-mediated endocytosis	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
GWAS		Metabolite levels ( 23823483 ) Refractive error ( 32231278 )	Airway wall thickness ( 25517131 ) Depression in smokers ( 30219690 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Fasting plasma glucose ( 32902719 ) Night sleep phenotypes ( 27126917 ) Osteoporosis-related phenotypes ( 20200953 ) Recurrent major depressive disorder x sex interaction ( 34099189 ) Response to hepatitis C treatment ( 22095909 ) Sodium levels ( 29403010 ) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 )
Interacting Genes		233 interacting genes: ABCC2 ACOT7 ADRM1 AGPAT5 AGR2 AGR3 ANOS1 APOC2 APOC4 APP ASCL1 ATXN3 BAG6 BPIFA1 C1QA C1QTNF2 C1QTNF4 CALU CARINH CCL3 CCL7 CD47 CD99 CD99L2 CDIP1 CDSN CEBPA CHGB CHRNA3 CHRNA4 CHRNB4 CLCN2 COL10A1 COL1A2 COL9A2 COLGALT2 COMTD1 COPS4 CSN3 CSTF2 CSTF2T CTAG1A CTAG1B CTAG2 CYB5R1 DAZAP2 DEFA6 DEFB115 DESI1 DEXI DMKN DNAJB2 DOLK ECM1 EFEMP2 ENTREP1 EP300 EPS15 ERP27 ERP29 ETNK1 F8 FAM163B FAM86B3P FAS FBXO25 FCGR2A FGF7 FKBP2 FN1 FOLR3 FZD7 GABRA1 GABRA2 GABRA3 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GAL GHRL GIT2 GKAP1 GPR162 GPX3 GRM2 GUCA2A GUCA2B GYPB HERC3 HES1 HGS HK2 HSD17B12 HSPA13 IER3IP1 IGFBP6 IGL IGLC1 IGLV2-14 IL6ST IST1 ITPRIPL1 JPH4 JSRP1 KLHL42 LAIR2 LAMB1 LCN2 LHX4 LITAF LNPEP MANBAL MAP3K1 MCM7 MDK MESD MICOS10-NBL1 MIEF1 MIEF2 MLLT6 MTNR1A MTOR MYDGF NAXD NBL1 NDE1 NDOR1 NEDD8 NGLY1 NLGN3 NME3 NPPA NPY NT5C3A NUP58 NXF1 OST4 P4HB PARVA PBXIP1 PCDH18 PCDHA4 PIAS2 PIK3IP1 PLAAT1 PLAAT2 PLAAT3 PNMA1 PPIB PPIC PRAP1 PRB1 PRPF40A PRR4 PSEN1 PSEN2 PSMD4 PSORS1C2 PTN RAI2 RARA RASSF5 RIC8A RNF144B RNF208 RNF4 RPN1 RPS27A RSRC2 RTL8A RTL8B RTL8C SCG2 SCG5 SCMH1 SERPINE1 SERPINI2 SEZ6L SIL1 SLC16A3 SLC29A2 SLPI SMAD9 SMIM19 SMIM2 SMR3B SMURF1 SOD3 SPAG8 SPARC SRGN STAM2 STMN3 SUSD4 SYNJ2BP TARDBP TFF1 TICAM1 TLR4 TMCO6 TMEM258 TMEM37 TMEM67 TMUB2 TNFAIP3 TNFRSF1A TNFRSF1B TREX1 TRIM23 TRIM32 TXNDC12 UBA52 UBB UBC UBE2I UBE2V1 UBQLN4 UBXN1 UBXN4 UBXN7 VWC2 WBP2 WFDC12 WWP2 XPO4 ZBTB8B ZFAND2B ZG16 ZG16B ZMYM5 ZNF343	5 interacting genes: ATRIP NRIP1 TUBB4B UBQLN1 UBQLN4
Entrez ID		29979	7857
HPRD ID		05440	06762
Ensembl ID		ENSG00000135018	ENSG00000171951
Uniprot IDs		Q9UMX0	P13521
PDB IDs		2JY5 2JY6 2KLC	Not available
GO Terms Enriched among Interactors		Extracellular Region Extracellular Ligand-gated Monoatomic Ion Channel Activity GABA-A Receptor Activity GABA-A Receptor Complex Protein Binding Extracellular Space GABA-gated Chloride Ion Channel Activity Regulation Of Postsynaptic Membrane Potential Gamma-aminobutyric Acid Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Specialization Membrane Synaptic Transmission, GABAergic Endoplasmic Reticulum Lumen Chloride Channel Complex Chloride Channel Activity Inhibitory Synapse Assembly Postsynaptic Membrane Positive Regulation Of Glial Cell Differentiation Polyubiquitin Modification-dependent Protein Binding Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Tag Activity Regulation Of Membrane Potential Transmembrane Signaling Receptor Activity Cell-cell Signaling Endoplasmic Reticulum Behavioral Response To Nicotine Regulation Of Tumor Necrosis Factor Production Regulation Of Mononuclear Cell Migration Regulation Of Proteolysis Synaptic Signaling Signaling Chemical Synaptic Transmission Positive Regulation Of Oligodendrocyte Differentiation Chloride Transmembrane Transport Benzodiazepine Receptor Activity Ubiquitin Binding GABA-ergic Synapse Proteolysis Monoatomic Anion Transmembrane Transport Macromolecule Catabolic Process Cell Communication Regulation Of Oligodendrocyte Differentiation Regulation Of Leukocyte Migration Chloride Transport Trans-synaptic Signaling Monoatomic Ion Channel Activity Oligosaccharyltransferase Complex Positive Regulation Of Nervous System Development Monoatomic Anion Transport	Polyubiquitin Modification-dependent Protein Binding Ovarian Follicle Rupture Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Cellular Response To Stress Autophagosome Nuclear Proteasome Complex ATR-ATRIP Complex Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Regulation Of Double-strand Break Repair Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy Cytosolic Proteasome Complex Regulation Of DNA Repair Autophagy K48-linked Polyubiquitin Modification-dependent Protein Binding Nuclear Retinoid X Receptor Binding Ovulation Nuclear Glucocorticoid Receptor Binding Nuclear Retinoic Acid Receptor Binding MHC Class I Protein Binding Response To Stress Aggrephagy Positive Regulation Of ERAD Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Autophagosome Maturation