A1CF and CELF2

Number of citations: 0 (PubMedID 11577082)
Data Source: HPRD (in vitro, in vivo)

		A1CF	CELF2
Name		APOBEC1 complementation factor	CUGBP Elav-like family member 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Apolipoprotein B MRNA Editing Enzyme Complex MRNA Editing Complex	Nucleus Nucleoplasm Cytoplasm Flemming Body Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Enzyme-substrate Adaptor Activity	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Pre-mRNA Binding
	Biological Process	MRNA Processing Embryo Implantation MRNA Localization Resulting In Post-transcriptional Regulation Of Gene Expression Cytidine To Uridine Editing MRNA Modification Low-density Lipoprotein Particle Clearance Protein Stabilization Chromosomal 5-methylcytosine DNA Demethylation Pathway Negative Regulation Of MRNA Catabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition RNA Processing MRNA Processing Regulation Of Heart Contraction
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome	None
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Colorectal cancer or advanced adenoma ( 30510241 ) Estimated glomerular filtration rate ( 31451708 31152163 31015462 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Gamma glutamyl transferase levels ( 33339817 ) Glomerular filtration rate (creatinine) ( 28452372 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Interferon alpha levels in systemic lupus erythematosus ( 25338677 ) LDL cholesterol ( 30275531 ) Low density lipoprotein cholesterol levels ( 32154731 ) Narcolepsy with cataplexy ( 25986216 ) Serum uric acid levels ( 30993211 ) Total cholesterol levels ( 30275531 ) Triglyceride levels ( 32154731 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglycerides ( 30275531 ) Urate levels ( 31578528 31985003 23263486 ) Urate levels in lean individuals ( 25811787 )	Activity variability during wake ( 33075057 ) Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Adverse response to drug ( 30420678 ) Age at first sexual intercourse ( 34211149 ) Allergic rhinitis ( 30013184 ) Asthma ( 29273806 34103634 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Basal cell carcinoma ( 33549134 ) Body size at age 10 ( 32376654 ) Breastfeeding duration ( 25475840 ) Chronic kidney disease ( 31015462 ) Cognitive function in longevity ( 33607172 ) General risk tolerance (MTAG) ( 30643258 ) Glaucoma (primary open-angle) ( 33627673 ) Glycemic traits (pleiotropy) ( 31021400 ) Liver enzyme levels (alanine transaminase) ( 24124411 ) Liver enzyme levels (aspartate transaminase) ( 24124411 ) Mean platelet volume ( 32888494 ) Motion sickness ( 25628336 ) Obesity-related traits ( 23251661 ) Offspring birth weight ( 31043758 ) Pulse pressure ( 30224653 ) Response to lamotrigine in genetic generalized epilepsy ( 32308125 ) Urinary albumin-to-creatinine ratio ( 26631737 )
Interacting Genes		26 interacting genes: ACTMAP APOBEC1 CAVIN2 CELF2 CYSRT1 DOK3 ECM1 EIF4G1 FHL2 FHL3 HSPB2 HSPB2-C11orf52 KHSRP KLHDC7B KRT31 KRT34 METTL27 OIP5 PLEKHG4 POGZ REL RIMBP3C SPMIP6 SYNCRIP TNPO2 TRAF1	23 interacting genes: A1CF APOBEC1 APP CEBPA ELAVL1 MIR140 MIR155 MIR18B MIR199A1 MIR19A MIR19B1 MIR205 MIR21 MIR29C MIR34B MIR363 MIR7-1 MIR9-2 MIRLET7I PCBP1 PTGS2 RNF10 TRAF3
Entrez ID		29974	10659
HPRD ID		10627	03964
Ensembl ID		ENSG00000148584	ENSG00000048740
Uniprot IDs		B4E1E3 F8W9F8 Q9NQ94	A0A0J9YX66 A0A0J9YXJ0 A0A1B0GU44 A0A1B0GUN8 B4DDE7 B4DIB6 B4DT00 B4DZ01 E9PC62 O95319
PDB IDs		2CPD	2MY7 2MY8 4LJM 4LMZ 4TLQ 5M8I
GO Terms Enriched among Interactors		Chromosomal 5-methylcytosine DNA Demethylation Pathway MRNA Editing Complex Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Modification Manchette	Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression RISC Complex MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Multicellular Organismal Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Developmental Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Endothelial Cell Migration Regulation Of Cardiac Muscle Hypertrophy Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Cytokine Production Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Extracellular Vesicle Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Striated Muscle Cell Apoptotic Process Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability MRNA Destabilization Negative Regulation Of Cell Migration Regulation Of Endothelial Cell Migration MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cell Population Proliferation RNA Destabilization Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of RNA Stability Regulation Of Developmental Process Regulation Of Cell Population Proliferation