LRP12 and ZFYVE9

Number of citations: 0 (PubMedID 12809483)
Data Source: HPRD (in vivo, two hybrid)

		LRP12	ZFYVE9
Name		LDL receptor related protein 12	zinc finger FYVE-type containing 9
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Clathrin-coated Pit Membrane	Cytoplasm Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Integrin Binding Protein Binding	Protein Binding 1-phosphatidylinositol Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Neuron Migration Endocytosis Cell Adhesion Signal Transduction Cell Migration Neuron Projection Development Integrin Activation Regulation Of Growth Lymphocyte Migration Into Lymphoid Organs	Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Endosomal Transport
Pathways		Retinoid metabolism and transport	None
GWAS		Blood protein levels ( 30072576 ) Daytime nap ( 33568662 ) Glaucoma (primary open-angle) ( 22570617 ) HOMA-B (corrected for HOMA-IR) ( 30369944 ) Impulsivity (attentional) ( 30718321 ) Irritable mood ( 29500382 ) Periodontitis (DPAL) ( 24024966 ) Systolic blood pressure ( 28739976 ) Vascular endothelial growth factor levels ( 21757650 )	Hip circumference adjusted for BMI ( 34021172 )
Interacting Genes		7 interacting genes: ACTN2 MYOT NMRK2 RACK1 SNAPIN SNCA ZFYVE9	38 interacting genes: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBIN ETS2 FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPART ST7 SUMF2 SUPT5H SVEP1 TENT5A TGFBR1 TGFBR2 UBC UBXN11 ZMYND8
Entrez ID		29967	9372
HPRD ID		17447	04782
Ensembl ID		ENSG00000147650	ENSG00000157077
Uniprot IDs		Q59H02 Q9Y561	O95405
PDB IDs		Not available	1DEV 1MK2 4BKW 5MJY
GO Terms Enriched among Interactors		Protein Domain Specific Binding Structural Constituent Of Muscle Positive Regulation Of Transport Actin Cytoskeleton Actin Filament Uncapping Regulation Of Vesicle-mediated Transport Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Synaptic Vesicle Transport SNARE Binding Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Neurotransmitter Secretion Synaptic Vesicle Exocytosis Neuronal Cell Body Positive Regulation Of Late Endosome To Lysosome Transport Actin Binding Positive Regulation Of Protein Localization To Cell Periphery Enzyme Activator Activity Titin Z Domain Binding Cytoplasm Negative Regulation Of Transport Regulation Of Membrane Potential Neurotransmitter Transport Regulation Of Neurotransmitter Secretion Vesicle-mediated Transport In Synapse Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Nicotinate Riboside Kinase Activity Cell Junction Organization Regulated Exocytosis Establishment Of Vesicle Localization Regulation Of Cellular Localization Positive Regulation Of Cation Transmembrane Transport Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Vesicle Localization Ribosylnicotinate Kinase Activity Ribosylnicotinamide Kinase Activity Cell Projection Positive Regulation Of Intracellular Transport Microspike Assembly Z Disc	Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Ubiquitin Protein Ligase Binding Embryonic Skeletal System Morphogenesis I-SMAD Binding SMAD Binding Lung Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Trachea Formation Trophoblast Cell Migration PTW/PP1 Phosphatase Complex Embryonic Organ Morphogenesis Photoperiodism Entrainment Of Circadian Clock Activin Receptor Signaling Pathway Embryonic Foregut Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cell Fate Commitment Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Tissue Development Gastrulation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Branching Involved In Lung Morphogenesis Tube Morphogenesis Positive Regulation Of Developmental Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription Elongation By RNA Polymerase II Mesenchyme Development Regulation Of Developmental Process Formation Of Primary Germ Layer Branching Morphogenesis Of An Epithelial Tube Osteoblast Differentiation Bronchus Development Animal Organ Formation Positive Regulation Of DNA-templated Transcription, Elongation Catenin-TCF7L2 Complex Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Translation In Response To Stress Circadian Regulation Of Gene Expression In Utero Embryonic Development Regulation Of SMAD Protein Signal Transduction Developmental Growth