GMPPB and TXNDC5

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		GMPPB	TXNDC5
Name		GDP-mannose pyrophosphorylase B	thioredoxin domain containing 5
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol GDP-mannose Pyrophosphorylase Complex	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endomembrane System Azurophil Granule Lumen Lysosomal Lumen Intracellular Organelle Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Mannose-1-phosphate Guanylyltransferase (GTP) Activity Protein Binding GTP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding	Protein Disulfide Isomerase Activity Protein Binding Protein-disulfide Reductase Activity Oxidoreductase Activity Isomerase Activity
	Biological Process	Protein Glycosylation GDP-mannose Biosynthetic Process GDP-mannose Metabolic Process GDP-mannose Biosynthetic Process From Mannose	Protein Folding Negative Regulation Of Apoptotic Process
Pathways		Synthesis of GDP-mannose	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Extremely high intelligence ( 29520040 ) Multisite chronic pain ( 31194737 ) Regular attendance at a gym or sports club ( 29970889 ) Regular attendance at a religious group ( 29970889 ) Resting heart rate ( 27798624 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 21297633 )	Blood protein levels ( 30072576 ) High chromosomal aberration frequency (chromatid type) ( 31586183 ) Mean corpuscular hemoglobin ( 32888494 ) Pelvic organ prolapse ( 32184442 )
Interacting Genes		5 interacting genes: DPPA4 GLYCTK GMPPA POLR1C TXNDC5	29 interacting genes: APP AR BLZF1 CEBPA EDEM3 EFEMP1 FLACC1 GMPPB KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 LHX4 MGAT5B NOTCH2NLA OGT PJA1 PRDX2 RAB3IP SPRY2 TRIM23 TRIM42 TRIP6 UBQLN2
Entrez ID		29925	81567
HPRD ID		13589	18249
Ensembl ID		ENSG00000173540	ENSG00000239264
Uniprot IDs		Q9Y5P6	A0A024QZV0 Q8NBS9
PDB IDs		7D72 7D73 7D74	2DIZ 3UJ1 3UVT 3WGD 3WGE 3WGX 8EKY
GO Terms Enriched among Interactors		Molecular Sensor Activity GDP-mannose Pyrophosphorylase Complex Mannose-1-phosphate Guanylyltransferase (GTP) Activity Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Glycerate Kinase Activity	Keratin Filament Intermediate Filament Protein Glycosylation Macromolecule Glycosylation Glycosylation Hair Cycle