GUCY1B1 and GUCY1A2

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro, in vivo)

		GUCY1B1	GUCY1A2
Name		guanylate cyclase 1 soluble subunit beta 1	guanylate cyclase 1 soluble subunit alpha 2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Guanylate Cyclase Complex, Soluble Protein-containing Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse	Cytoplasm Cytosol Guanylate Cyclase Complex, Soluble
	Molecular Function	Nucleotide Binding Adenylate Cyclase Activity Guanylate Cyclase Activity Protein Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Heme Binding Signaling Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cytidylate Cyclase Activity Hsp90 Protein Binding Nitric Oxide Binding	Nucleotide Binding Guanylate Cyclase Activity Protein Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Heme Binding
	Biological Process	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Circulation Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Intracellular Signal Transduction Nitric Oxide-cGMP-mediated Signaling Response To Oxygen Levels Cellular Response To Nitric Oxide	CGMP Biosynthetic Process Signal Transduction Nitric Oxide Mediated Signal Transduction Cyclic Nucleotide Biosynthetic Process Positive Regulation Of Nitric Oxide Mediated Signal Transduction CGMP-mediated Signaling Intracellular Signal Transduction Response To Oxygen Levels
Pathways		Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction Smooth Muscle Contraction	Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction Smooth Muscle Contraction
Drugs		Isosorbide Vericiguat	Nitric Oxide Isosorbide mononitrate Riociguat Methylene blue Molsidomine Isosorbide Plecanatide
GWAS		No GWAS studies recorded	Anxiety disorder ( 25390645 ) Colorectal or endometrial cancer ( 26621817 ) Diastolic blood pressure ( 27841878 ) Obesity-related traits ( 23251661 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 ) Upper eyelid morphology ( 29921221 ) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738 ) Whole brain grey matter density ( 31530798 )
Interacting Genes		5 interacting genes: AGAP1 APP DSCR9 GUCY1A2 HSP90AA1	9 interacting genes: DLG1 DLG2 DLG3 DLG4 ERBIN GSC2 GUCY1B1 SNTA1 STUB1
Entrez ID		2983	2977
HPRD ID		00769	03146
Ensembl ID		ENSG00000061918	ENSG00000152402
Uniprot IDs		B7Z685 B7Z6G8 B7Z9H9 D6RC99 E9PCN2 Q02153	P33402
PDB IDs		2WZ1 3UVJ 4NI2 5MNW 6JT0 6JT1 6JT2 7D9R 7D9S 7D9T 7D9U 8HBE 8HBF 8HBH	Not available
GO Terms Enriched among Interactors		Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process GTP Binding CTP Binding DATP Binding Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Protein Localization To Nucleus Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Guanylate Cyclase Complex, Soluble Rho GDP-dissociation Inhibitor Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Nitric Oxide Mediated Signal Transduction Sperm Mitochondrial Sheath Postsynaptic Endosome Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Telomerase Holoenzyme Complex Assembly Axon Choice Point Recognition	Neuromuscular Junction Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Kinase Binding Ionotropic Glutamate Receptor Binding Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Cell Polarity Protein Localization To Synapse Protein Localization To Cell Junction Postsynaptic Density Membrane Adherens Junction Glutamatergic Synapse Basolateral Plasma Membrane GMP Kinase Activity Chemical Synaptic Transmission GDP Metabolic Process Protein Localization To Membrane Neuron Projection Trans-synaptic Signaling Juxtaparanode Region Of Axon Synaptic Signaling Cellular Response To Potassium Ion Cell Adhesion Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Biological Quality Response To Potassium Ion Protein Kinase Binding Cell-cell Adhesion AMPA Glutamate Receptor Complex GMP Metabolic Process Localization Within Membrane Protein Localization To Postsynaptic Membrane Regulation Of System Process Cell Junction Protein Localization To Postsynapse Nervous System Development Cell-cell Signaling Regulation Of Sodium Ion Transmembrane Transport Signaling Hsp90 Protein Binding Cell Communication Postsynaptic Density Regulation Of Blood Circulation Phosphatase Binding Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process System Process Ribose Phosphate Metabolic Process