GUCY1A1 and AGAP1

Number of citations: 0 (PubMedID 15381706)
Data Source: HPRD (two hybrid, in vivo)

		GUCY1A1	AGAP1
Name		guanylate cyclase 1 soluble subunit alpha 1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Guanylate Cyclase Complex, Soluble Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Postsynaptic Endosome
	Molecular Function	Nucleotide Binding Guanylate Cyclase Activity Protein Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Heme Binding Signaling Receptor Activity	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Phospholipid Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Circulation Regulation Of Blood Pressure Cyclic Nucleotide Biosynthetic Process Positive Regulation Of Nitric Oxide Mediated Signal Transduction CGMP-mediated Signaling Intracellular Signal Transduction Nitric Oxide-cGMP-mediated Signaling Relaxation Of Vascular Associated Smooth Muscle Response To Oxygen Levels Retrograde Trans-synaptic Signaling By Nitric Oxide, Modulating Synaptic Transmission	Protein Transport Regulation Of Modification Of Postsynaptic Structure
Pathways		Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction Smooth Muscle Contraction	None
Drugs		Isosorbide	None
GWAS		Appendicular lean mass ( 33097823 )	Adult body size ( 32376654 ) Anterior thalamic nuclei volume ( 34006833 ) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Craniofacial microsomia ( 26853712 ) Mean corpuscular hemoglobin ( 29403010 ) Mean corpuscular volume ( 29403010 ) Menarche (age at onset) ( 23667675 ) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668 )
Interacting Genes		4 interacting genes: AGAP1 IKBKG MAPK8 STUB1	16 interacting genes: APP ARF1 ARF6 CDC42 DYRK1A GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA RSPH14 SMN1 SRC TK1 WEE2-AS1 ZNF534
Entrez ID		2982	116987
HPRD ID		00768	16359
Ensembl ID		ENSG00000164116	ENSG00000157985
Uniprot IDs		B3KU69 Q02108	B2RZG9 E7EUN2 Q9UPQ3
PDB IDs		3UVJ 4NI2 6JT0 6JT1 6JT2 7D9R 7D9S 7D9T 7D9U 8HBE 8HBF 8HBH	7EB6
GO Terms Enriched among Interactors		Regulation Of Macroautophagy Regulation Of Autophagy JUN Phosphorylation Positive Regulation Of Catabolic Process Ubiquitin Ligase Complex Positive Regulation Of Macroautophagy Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly DNA Damage Response Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process JUN Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Linear Polyubiquitin Binding Negative Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Proteolysis Ubiquitin Conjugating Enzyme Complex Histone Deacetylase Regulator Activity Basal Dendrite MAPK Cascade Postsynaptic Endosome Immune Response-regulating Cell Surface Receptor Signaling Pathway IkappaB Kinase Complex Chaperone-mediated Autophagy Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ubiquitin Protein Ligase Binding TPR Domain Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cellular Response To Stress Regulation Of Protein Metabolic Process Transferrin Receptor Binding Regulation Of Proteolysis Anoikis Nuclear Inclusion Body Regulation Of Glucocorticoid Metabolic Process Regulation Of Vascular Associated Smooth Muscle Contraction Cellular Response To Misfolded Protein Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Vasoconstriction Response To Misfolded Protein Enzyme Binding Immune Response-regulating Signaling Pathway Regulation Of Protein-containing Complex Assembly	Regulation Of Supramolecular Fiber Organization GTP Binding Membrane Invagination Thioesterase Binding Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Regulation Of Endocytosis G Protein Activity Regulation Of Cell-substrate Junction Organization Guanylate Cyclase Complex, Soluble Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Establishment Of Epithelial Cell Polarity Positive Regulation Of Locomotion Postsynapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cell Projection Organization Regulation Of Cell Junction Assembly Neuron Projection Organization Regulation Of Receptor-mediated Endocytosis Cell Junction Organization Regulation Of Actin Filament Organization Positive Regulation Of Cytokinesis Negative Regulation Of Cellular Component Organization Substrate Adhesion-dependent Cell Spreading Nucleotide Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Synapse Organization Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Signaling Receptor Activator Activity Positive Regulation Of Stress Fiber Assembly Guanylate Cyclase Activity Regulation Of Cytoskeleton Organization GTPase Activity Establishment Or Maintenance Of Cell Polarity Circulatory System Process Nitric Oxide-cGMP-mediated Signaling Regulation Of Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Glutamatergic Synapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Podosome Assembly Flavonoid Metabolic Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly