GSK3B and LRP6

Number of citations: 0 (PubMedID 16365045)
Data Source: BioGRID (affinity chromatography technology, enzymatic study), HPRD (in vitro)

		GSK3B	LRP6
Name		glycogen synthase kinase 3 beta	LDL receptor related protein 6
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Centrosome Cytosol Plasma Membrane Membrane Axon Dendrite Beta-catenin Destruction Complex Presynapse Postsynapse Glutamatergic Synapse Wnt Signalosome	Extracellular Region Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Cell Surface Membrane Cytoplasmic Vesicle Early Endosome Membrane Neuronal Cell Body Membrane Raft Synapse Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome
	Molecular Function	Nucleotide Binding Protease Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Beta-catenin Binding Kinase Activity Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding Dynactin Binding Tau Protein Binding Tau-protein Kinase Activity NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Scaffold Protein Binding Protein Serine Kinase Activity	Low-density Lipoprotein Particle Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Coreceptor Activity Wnt-protein Binding Kinase Inhibitor Activity Toxin Transmembrane Transporter Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Wnt Receptor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Epithelial To Mesenchymal Transition Positive Regulation Of Cell-matrix Adhesion Cytoplasmic Translational Initiation Heart Valve Development Glycogen Metabolic Process Protein Phosphorylation ER Overload Response Mitochondrion Organization Regulation Of Mitotic Cell Cycle Nervous System Development Circadian Rhythm Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Viral Protein Processing Hippocampus Development Establishment Of Cell Polarity Maintenance Of Cell Polarity Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Regulation Of Axon Extension SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Ubiquitination Negative Regulation Of TOR Signaling Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule-based Process Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Cellular Response To Interleukin-3 TORC2 Signaling Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cilium Assembly Positive Regulation Of Translation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Export From Nucleus Rhythmic Process Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Excitatory Postsynaptic Potential Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Superior Temporal Gyrus Development Cellular Response To Retinoic Acid Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Presynaptic Modulation Of Chemical Synaptic Transmission Neuron Projection Organization Membraneless Organelle Assembly Regulation Of Microtubule Anchoring At Centrosome Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Cellular Response To Heat Negative Regulation Of Protein Localization To Nucleus Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Cilium Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Cellular Response To Amyloid-beta Positive Regulation Of Protein Localization To Centrosome Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Mesenchymal Stem Cell Differentiation	Regulation Of DNA-templated Transcription Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Nervous System Development Tissue Development Neural Crest Formation Neural Crest Cell Differentiation Wnt Signaling Pathway Vesicle-mediated Transport Midbrain Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Chordate Embryonic Development Response To Peptide Hormone Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Transmembrane Transport Canonical Wnt Signaling Pathway Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Protein Localization To Plasma Membrane Cell-cell Adhesion Midbrain Dopaminergic Neuron Differentiation
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade AKT phosphorylates targets in the cytosol Regulation of HSF1-mediated heat shock response CRMPs in Sema3A signaling Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane B-WICH complex positively regulates rRNA expression Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Constitutive Signaling by AKT1 E17K in Cancer Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D Regulation of RUNX2 expression and activity Maturation of nucleoprotein Maturation of nucleoprotein GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Transcriptional and post-translational regulation of MITF-M expression and activity GSK3B-mediated proteasomal degradation of PD-L1(CD274)	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs		Lithium cation 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione SB-409513 AR-AO-14418 Staurosporine Indirubin-3'-monoxime 6-bromoindirubin-3'-oxime Alsterpaullone Phosphoaminophosphonic Acid-Adenylate Ester 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE Fostamatinib Tideglusib Lithium citrate Lithium succinate Lithium carbonate	None
GWAS		HDL cholesterol ( 24097068 ) HDL cholesterol levels ( 28334899 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Neutrophil count ( 32888494 ) Platelet distribution width ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 )	Cerebrospinal fluid t-tau levels in normal cognition ( 29274321 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 ) Coronary artery calcification ( 23870195 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Heel bone mineral density ( 30598549 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Tandem gait ( 26219847 )
Interacting Genes		245 interacting genes: ACLY ACSBG1 ACTL6B ADAP1 ADIRF AKAP11 AKT1 AKT2 AKT3 APC APP AR ARRB1 ASRGL1 ATP5IF1 ATXN3 AURKA AXIN1 AXIN2 BAG6 BCCIP BCL2A1 BCL2L1 BCL2L12 BCL3 BEX1 BHLHE41 BICD1 BICD2 BRIX1 BTRC BZW2 C10orf90 C11orf98 CABYR CAMSAP3 CCND1 CCNE1 CDH1 CDK5 CDX2 CEBPA CEBPD CEBPZ CENPB CHD3 CIITA CLEC3B CMTM2 CREB1 CREB3L3 CREM CSAD CSNK2B CST6 CTNNB1 CTNND1 DBI DCP1B DCTN1 DCTN2 DCTN3 DDIT4 DEAF1 DEFA1 DELEC1 DHX34 DISC1 DNAJC13 DNM1L DNMT1 DNMT3L DPYSL2 DRC9 DUSP9 DYNC1I1 E2F1 EEF1G EFTUD2 EIF2B5 EIF4EBP1 ENTPD6 ERG28 EYA1 FAM193B FAM83D FBN3 FBXL21P FBXO7 FBXW11 FEN1 FIBP FKBP14 FOXO1 FRAT1 FRAT2 FZD5 GBP2 GFI1 GIPC1 GJB5 GOLM2 GPR39 GRIA2 GYS1 HDAC4 HNRNPD HNRNPM HSP90AB1 HSPA4 IGHM IGSF21 IKBKG ILK IRF1 JUN KDM1A KHSRP KIAA1191 KIF5B KLF2 KLF5 LMO4 LPCAT1 LRP6 LUC7L2 LYAR MAP1B MAP3K1 MAP3K4 MAP4 MAPK1 MAPT MARK2 MASP1 MCL1 MDM2 MED24 MEG3 MICAL1 MID1IP1 MITF MPP1 MTF2 MTOR MUC1 MYC MYL6 MYOCD MYOZ1 NAT9 NBR1 NCOA3 NDRG1 NFE2L1 NFE2L2 NFE2L3 NFKB1 NIN NOTCH1 NOTCH2 NRBP1 NSFL1C OGA OGT PDE4D PDPK1 PFKFB4 PHLPP1 PIAS1 PICK1 PIM2 PMAIP1 PPARGC1A PPP1R2 PRKACA PRKCA PRKCB PRKCZ PRKDC PRKRIP1 PSEN1 PSMD8 PTK2 PTN PTPA PTPN1 PXN QARS1 RAI1 RBPJ RCAN1 RELB RICTOR RPL36AL RPLP1 RPS15 RPS2 RPS6KA1 RSU1 RXRA SAP30BP SGK1 SGK3 SLA SMAD3 SMG7 SNAI1 SNCAIP SOX10 SPI1 SPTBN4 SREBF1 STAT2 SYNE4 TAFAZZIN TCAP TEKT5 TLE1 TMEM132A TMEM44 TONSL TP53 TPPP TRIM72 TSC2 TUBA1A UBE2D1 UBR1 UBR5 UBXN6 UFM1 UPF3A VIM VPS51 XIAP XPNPEP1 YBX1 YBX3 YWHAZ ZFPM1 ZHX1 ZNF135 ZNF227 ZNF746	18 interacting genes: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 CKLF DKK1 DKK2 FZD5 FZD8 GSK3A GSK3B LRRK2 MDK SERPINF1 TLNRD1 WNT1 WNT3A
Entrez ID		2932	4040
HPRD ID		05418	04617
Ensembl ID		ENSG00000082701	ENSG00000070018
Uniprot IDs		A0A3B3ITW1 P49841 Q6FI27	F5H7J9 O75581
PDB IDs		1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2O5K 2OW3 2UW9 2X39 2XH5 3CQU 3CQW 3DU8 3E87 3E88 3E8D 3F7Z 3F88 3GB2 3I4B 3L1S 3M1S 3MV5 3OW4 3PUP 3Q3B 3QKK 3QKL 3SAY 3SD0 3ZDI 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH 4AFJ 4B7T 4DIT 4EKK 4IQ6 4J1R 4J71 4NM0 4NM3 4NM5 4NM7 4PTC 4PTE 4PTG 5F94 5F95 5HLN 5HLP 5K5N 5KPK 5KPL 5KPM 5OY4 5T31 6B8J 6BUU 6GJO 6GN1 6H0U 6HK3 6HK4 6HK7 6NPZ 6TCU 6V6L 6Y9R 6Y9S 7B6F 7OY5 7SXH 7SXJ 7U2Z 7U31 7U33 7U36 7Z1F 7Z1G 8AUZ 8AV1 8DJC 8DJD 8DJE 8FF8 8QJI 8XN6	3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6 4NM5 4NM7 5AIR 5FWW 5GJE 6H15 6H16 6L6R 7NAM 8CTG 8DVL 8DVM 8DVN 8FFE 8S7C
GO Terms Enriched among Interactors		Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Cytosol Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleus Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytoplasm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Cell Communication Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Regulation Of Cell Differentiation Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Developmental Process Signal Transduction	Wnt Signaling Pathway Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Co-receptor Binding Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Apoptotic Process Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Regulation Of Dopaminergic Neuron Differentiation Beta-catenin Destruction Complex Wnt Signalosome Cell Surface Receptor Signaling Pathway Regulation Of Cell Differentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Gene Expression Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Cell Differentiation Positive Regulation Of Dermatome Development Signal Transduction Response To Retinoic Acid Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Membrane Permeability Anatomical Structure Morphogenesis Regulation Of Mitochondrion Organization Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Dopaminergic Neuron Differentiation Spemann Organizer Formation Wnt-Frizzled-LRP5/6 Complex Regulation Of Cellular Component Organization Positive Regulation Of Post-translational Protein Modification Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cell Proliferation In Midbrain Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction T Cell Differentiation In Thymus Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Wnt Signaling Pathway Cellular Response To Oxygen-containing Compound