C1GALT1C1 and LGALS3

Number of citations: 34 (PubMedID 18695044)
Data Source: BioGRID (pull down)

		C1GALT1C1	LGALS3
Name		C1GALT1 specific chaperone 1	galectin 3
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Membrane Extracellular Exosome	Immunological Synapse Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity	RNA Binding Protein Phosphatase Inhibitor Activity Protein Binding IgE Binding Protein Phosphatase Binding Carbohydrate Binding Signaling Receptor Inhibitor Activity Chemoattractant Activity Laminin Binding Disaccharide Binding Oligosaccharide Binding Molecular Condensate Scaffold Activity Receptor Ligand Inhibitor Activity
	Biological Process	Protein O-linked Glycosylation Platelet Activation Platelet Morphogenesis	Immune System Process Monocyte Chemotaxis MRNA Processing RNA Splicing Cell Differentiation Neutrophil Chemotaxis Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly Killing Of Cells Of Another Organism Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Endocytosis Eosinophil Chemotaxis Macrophage Chemotaxis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis NK T Cell Activation Negative Regulation Of NK T Cell Activation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of T Cell Apoptotic Process Mononuclear Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Import Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Defective C1GALT1C1 causes TNPS O-linked glycosylation of mucins	Neutrophil degranulation Advanced glycosylation endproduct receptor signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX2 regulates genes involved in differentiation of myeloid cells
Drugs		None	2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide Lactose
GWAS		Serum galactose-deficient IgA1 levels ( 28187132 )	Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Leukoderma in response to rhododendrol ( 32558222 ) Protein biomarker ( 23056639 ) Testicular germ cell tumor ( 28604728 )
Interacting Genes		3 interacting genes: B3GNT2 C1GALT1 LGALS3	32 interacting genes: ANXA1 APP C1GALT1C1 CRX CSNK1A1 CSNK2A1 CSNK2A2 CUBN ELN FCGR2A GEMIN4 GOLGA2 INCA1 KIF16B LGALS3BP LIM2 LINC00632 MCAM MCPH1 MEFV MMP2 MYOC PPIG PRR13 SNCA SS18L1 SUFU TRIM17 TRIM22 TRIM23 TRIM6 ZFTRAF1
Entrez ID		29071	3958
HPRD ID		06462	01090
Ensembl ID		ENSG00000171155	ENSG00000131981
Uniprot IDs		Q96EU7	A0A024R693 P17931
PDB IDs		Not available	1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ 5NF7 5NF9 5NFA 5NFB 5NFC 5OAX 5ODY 6B8K 6EOG 6EOL 6EXY 6EYM 6F2Q 6F6Y 6FK2 6FOF 6G0V 6H64 6I74 6I75 6I76 6I77 6I78 6KXA 6KXB 6Q0Q 6Q17 6QGE 6QGF 6QLN 6QLO 6QLP 6QLQ 6QLR 6QLS 6QLT 6QLU 6RHL 6RHM 6RZF 6RZG 6RZH 6RZI 6RZJ 6RZK 6RZL 6RZM 6TF6 6TF7 6Y4C 6Y78 6ZVF 7BE3 7CXA 7DF5 7RDO 7RDP 7RGX 7RGY 7RGZ 7RH0 7RH1 7RH3 7RH4 7XFA 7ZQX 8BZ3 8ITX 8ITZ 8OJI 8OJK 8OJM 8OJO 8PBF 8PF9 8PFF 8PPN 8RMT 8RMU 8RMV 8RR7 8RR8 8RR9 8RRA 8RRB 8RRC 8RRE 8RRF 8RRG 8S67 8YMD 8Z1S 8Z1T 8Z25 8ZUV
GO Terms Enriched among Interactors		Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Protein O-linked Glycosylation Protein Glycosylation Glycosyltransferase Activity Glycosylation Macromolecule Glycosylation Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Glycoprotein Biosynthetic Process Negative Regulation Of NK T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Glycoprotein Metabolic Process Positive Regulation Of Dendritic Cell Differentiation Receptor Ligand Inhibitor Activity IgE Binding N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Poly-N-acetyllactosamine Biosynthetic Process Poly-N-acetyllactosamine Metabolic Process Signaling Receptor Inhibitor Activity NK T Cell Activation N-acetyl-beta-D-glucosaminide Beta-(1,3)-galactosyltransferase Activity Intestinal Epithelial Cell Development Carbohydrate Derivative Biosynthetic Process Oligosaccharide Binding Keratan Sulfate Proteoglycan Biosynthetic Process Regulation Of Dendritic Cell Differentiation Keratan Sulfate Proteoglycan Metabolic Process Columnar/cuboidal Epithelial Cell Development Macrophage Chemotaxis Laminin Binding Macrophage Migration Monocyte Chemotaxis Eosinophil Migration Eosinophil Chemotaxis Golgi Membrane Hexosyltransferase Activity Positive Regulation Of Calcium Ion Import Negative Regulation Of T Cell Receptor Signaling Pathway Chemoattractant Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Carbohydrate Derivative Metabolic Process Regulation Of T Cell Apoptotic Process Immunological Synapse Positive Chemotaxis Regulation Of Calcium Ion Import Protein Phosphatase Inhibitor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Molecular Condensate Scaffold Activity Negative Regulation Of Alpha-beta T Cell Activation Regulation Of T Cell Receptor Signaling Pathway	Regulation Of Autophagy Positive Regulation Of Autophagy Protein Kinase CK2 Complex Positive Regulation Of Catabolic Process Negative Regulation Of Catabolic Process Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Defense Response Response To External Biotic Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Vesicle Fusion Response To Interleukin-1 Regulation Of Proteolysis Protein Tetramerization Regulation Of Protein Catabolic Process Regulation Of Neurotransmitter Uptake Ubiquitin Protein Ligase Activity Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Defense Response Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Inflammatory Response Response To Other Organism Vesicle-mediated Transport Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cellular Response To Copper Ion Identical Protein Binding Negative Regulation Of Autophagy Regulation Of Receptor Recycling