GRIN2D and NANOS1

Number of citations: 0 (PubMedID 10862698)
Data Source: HPRD (in vivo)

		GRIN2D	NANOS1
Name		glutamate ionotropic receptor NMDA type subunit 2D	nanos C2HC-type zinc finger 1
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane NMDA Selective Glutamate Receptor Complex Presynaptic Membrane Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Glutamate-gated Receptor Activity NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Glutamate Binding Voltage-gated Monoatomic Cation Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	RNA Binding MRNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Translation Repressor Activity Metal Ion Binding
	Biological Process	Startle Response Monoatomic Ion Transport Brain Development Adult Locomotory Behavior Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Regulation Of Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Regulation Of Presynaptic Membrane Potential Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To L-glutamate Positive Regulation Of Excitatory Postsynaptic Potential	Regulation Of Cell Growth Tissue Homeostasis Regulation Of Translation Post-transcriptional Regulation Of Gene Expression Epithelial Cell Migration Cell Migration Negative Regulation Of Translation Oogenesis MRNA Destabilization Cerebellar Neuron Development
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	None
Drugs		Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Orphenadrine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)	None
GWAS		No GWAS studies recorded	Alcoholic chronic pancreatitis ( 28754779 ) Keratoconus ( 33649486 ) Serum alkaline phosphatase levels ( 33547301 )
Interacting Genes		33 interacting genes: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA MAP2 MAP2K2 NANOS1 NF1 PATJ PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3	3 interacting genes: GRIN1 GRIN2D PUM2
Entrez ID		2906	340719
HPRD ID		04095	16302
Ensembl ID		ENSG00000105464	ENSG00000188613
Uniprot IDs		O15399 Q59G17	Q8WY41
PDB IDs		7YFF 7YFL 7YFM 7YFO 7YFR 8E96 8Y1V 9D37 9D38 9D39 9D3A 9D3B 9D3C	4CQO
GO Terms Enriched among Interactors		Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Synapse Protein Kinase Binding Regulation Of Cytoskeleton Organization Glutamatergic Synapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Regulation Of Organelle Organization Regulation Of Biological Quality Regulation Of Long-term Neuronal Synaptic Plasticity Cytosol Plasma Membrane Cytoplasm Regulation Of MAPK Cascade Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Chemical Synaptic Transmission Neuron Apoptotic Process Dendrite Cell Junction Receptor Clustering Trans-synaptic Signaling Neuron Projection Regulation Of Anatomical Structure Morphogenesis Regulation Of Transport Synaptic Signaling Response To Morphine Diacylglycerol-dependent Serine/threonine Kinase Activity Perinuclear Region Of Cytoplasm MAPK Cascade Regulation Of Cellular Localization Schwann Cell Development Synaptic Membrane Regulation Of Neuron Apoptotic Process Positive Regulation Of Synaptic Transmission Postsynaptic Density Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Intracellular Protein Localization Learning Or Memory Learning Negative Regulation Of Protein Ubiquitination Regulation Of Developmental Process Regulation Of Microtubule Cytoskeleton Organization Disordered Domain Specific Binding	NMDA Selective Glutamate Receptor Complex Excitatory Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity NMDA Glutamate Receptor Activity Glutamate Binding Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Regulation Of Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Transmembrane Import Into Cytosol Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Response To Amino Acid Regulation Of Nervous System Process Propylene Metabolic Process Pumilio-response Element Binding Positive Regulation Of Synaptic Transmission Monoatomic Ion Channel Activity Calcium-mediated Signaling Response To Glycine Positive Regulation Of Sprouting Of Injured Axon Calcium Ion Transmembrane Transport Regulation Of Synaptic Plasticity Glycine-gated Cation Channel Activity Postsynaptic Membrane Brain Development Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Signaling Receptor Activity Positive Regulation Of Signal Transduction Regulation Of Monoatomic Ion Transmembrane Transport Chemical Synaptic Transmission Regulation Of Intracellular MRNA Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Trans-synaptic Signaling Synaptic Signaling Voltage-gated Monoatomic Cation Channel Activity Cellular Response To L-glutamate Positive Regulation Of Axon Regeneration Glycine Binding Regulation Of Monoatomic Ion Transport Glutamate-gated Receptor Activity Neurotransmitter Receptor Complex