GRIN2C and PATJ

Number of citations: 0 (PubMedID 9647694)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		GRIN2C	PATJ
Name		glutamate ionotropic receptor NMDA type subunit 2C	PATJ crumbs cell polarity complex component
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane NMDA Selective Glutamate Receptor Complex Organelle Synapse Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Centriolar Satellite Apical Junction Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Tight Junction Anchoring Junction
	Molecular Function	NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding
	Biological Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Brain Development Response To Wounding Directional Locomotion Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Negative Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Excitatory Postsynaptic Potential	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tight Junction Assembly
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs		Glutamic acid Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)	None
GWAS		Congenital heart disease (maternal effect) ( 28468790 ) Femur bone mineral density x serum urate levels interaction ( 34046847 )	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445 ) Autism spectrum disorders (social interaction) ( 32624584 ) Daytime nap ( 33568662 ) Excessive daytime sleepiness ( 27992416 ) Sleep traits (multi-trait analysis) ( 27992416 ) Type 2 diabetes ( 30297969 )
Interacting Genes		6 interacting genes: DLG3 DLG4 DLGAP1 ERBIN IL16 PATJ	35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3
Entrez ID		2905	10207
HPRD ID		00699	04434
Ensembl ID		ENSG00000161509	ENSG00000132849
Uniprot IDs		A0A8D9PH81 H0Y2V8 O15398 Q14957 Q8IW23	A0A2R8Y549 Q8NI35
PDB IDs		8E92 8E93 8E94 8E97 8E98 8E99	1VF6 2D92 2DAZ 2DB5 2DLU 2DM8 2DMZ 2EHR 4Q2N 6IRD
GO Terms Enriched among Interactors		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Postsynaptic Specialization Glutamatergic Synapse Cell Junction AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Binding Chemical Synaptic Transmission Receptor Clustering Receptor Localization To Synapse Trans-synaptic Signaling Synaptic Signaling Protein Localization To Synapse Protein Localization To Cell Junction Plasma Membrane P2Y1 Nucleotide Receptor Binding Postsynaptic Density Membrane Kinase Binding Basal Protein Localization Bicellular Tight Junction Cell-cell Signaling Signaling Cell Communication Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Positive Regulation Of Neutrophil Activation ErbB-2 Class Receptor Binding Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Adherens Junction AMPA Glutamate Receptor Clustering Neuroligin Family Protein Binding NMDA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Monocyte Chemotactic Protein-1 Production Cell Adhesion D1 Dopamine Receptor Binding Positive Regulation Of Interleukin-1 Alpha Production Cerebellar Mossy Fiber Synaptic Vesicle Maturation Neuron Spine Positive Regulation Of Neuron Projection Arborization Postsynapse Hemidesmosome Basolateral Plasma Membrane Postsynaptic Density CD4 Receptor Binding Regulation Of Neutrophil Activation Juxtaparanode Region Of Axon	Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Channel Activity Regulation Of Synaptic Transmission, Glutamatergic NMDA Glutamate Receptor Activity Metal Ion Transport NMDA Selective Glutamate Receptor Complex Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Monoatomic Ion Channel Complex Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Modulation Of Chemical Synaptic Transmission Monoatomic Ion Channel Activity Modulation Of Excitatory Postsynaptic Potential System Process Glutamate Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Neuronal Synaptic Plasticity Monoatomic Ion Transport Protein Localization To Synapse Regulation Of Nervous System Process Chemical Synaptic Transmission Trans-synaptic Signaling Postsynaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Synaptic Signaling Positive Regulation Of Synaptic Transmission Dendritic Spine Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Plasma Membrane Transmembrane Transport Regulation Of System Process Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Glutamatergic Synapse Synapse Ligand-gated Ion Channel Signaling Pathway Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Protein Localization To Membrane Regulation Of Synaptic Plasticity Dendrite Membrane Depolarization Long-term Synaptic Potentiation