GRID2 and DLG2

Number of citations: 41 (PubMedID 10234023)
Data Source: HPRD (two hybrid, in vivo)

		GRID2	DLG2
Name		glutamate ionotropic receptor delta type subunit 2	discs large MAGUK scaffold protein 2
Structure
GO Annotations	Cellular Component	Plasma Membrane Ionotropic Glutamate Receptor Complex Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Dendritic Spine Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Trans-synaptic Protein Complex Postsynaptic Density Membrane Glutamatergic Synapse	Cytosol Plasma Membrane Adherens Junction Voltage-gated Potassium Channel Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Axon Neuromuscular Junction Cell Projection Neuron Projection Perikaryon Juxtaparanode Region Of Axon Synapse Postsynaptic Density Membrane Axon Cytoplasm
	Molecular Function	AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	GMP Kinase Activity Protein Binding Kinase Binding Protein Kinase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Monoatomic Ion Transport Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Intracellular Protein Localization Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Prepulse Inhibition Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Density Assembly Synaptic Signaling Via Neuropeptide Positive Regulation Of Long-term Synaptic Depression Excitatory Synapse Assembly Regulation Of Presynapse Assembly	Chemical Synaptic Transmission Nervous System Development Protein Localization To Synapse Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport
Pathways		None	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
GWAS		Coffee consumption ( 31046077 ) Intelligence (MTAG) ( 29326435 ) Manganese levels ( 26025379 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Obsessive-compulsive disorder ( 30456828 ) Obsessive-compulsive traits ( 33531474 ) Pancreatic beta-cell glucose sensitivity ( 32944759 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Smoking initiation ( 33082346 )	Adult body size ( 32376654 ) Age at first sexual intercourse ( 27089180 ) Attention function in attention deficit hyperactive disorder ( 26174813 ) BMI at adiposity rebound ( 31840077 ) Body fat mass ( 28552196 ) Body mass index ( 28552196 ) Brain morphology (MOSTest) ( 32665545 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 ) Chronic obstructive pulmonary disease ( 25584925 ) Chronic periodontitis ( 25008200 ) Estrogen level change in anastrozole-treated breast cancer ( 32701512 ) Familial squamous cell lung carcinoma ( 29924316 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Height ( 28552196 ) Influenza A (H1N1) infection ( 26379185 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Lung adenocarcinoma (survival time) in never smokers ( 32699080 ) Migraine without aura ( 28952330 ) Mild influenza (H1N1) infection ( 26379185 ) Modic changes ( 30808802 ) Myopia ( 27182965 ) Nicotine dependence symptom count ( 25555482 ) Obesity-related traits ( 23251661 ) Oily fish consumption ( 32066663 ) Pallidum volume ( 31530798 ) Parkinson's disease ( 32201043 32310270 28892059 28011712 25064009 17052657 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Phospholipid levels (plasma) ( 22359512 ) Pork consumption ( 32066663 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Protein quantitative trait loci ( 18464913 ) Putamen volume ( 29147026 ) Refractive error ( 32231278 ) Response to fenofibrate (triglyceride levels) ( 27002377 ) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627 ) Schizophrenia ( 30285260 ) Schizophrenia x sex interaction ( 34099189 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Subcortical brain region volumes ( 25607358 ) Trunk fat mass ( 28552196 ) Type 2 diabetes ( 31049640 ) Urate levels in overweight individuals ( 25811787 ) Weight ( 28552196 ) Wilms tumor ( 22544364 )
Interacting Genes		10 interacting genes: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4	54 interacting genes: ABCA1 AOAH ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DSCAM ERBB4 FA2H FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 PLEKHA2 PPIL4 RNASE2 RPF2 RPS8 SCN4A SCN5A SEMA4C SERPINB13 VANGL2 VTN WNT3A
Entrez ID		2895	1740
HPRD ID		06781	04663
Ensembl ID		ENSG00000152208	ENSG00000150672
Uniprot IDs		O43424	A0A3B3ISW2 A0A5F9ZH92 A0A994J570 A0A994J587 A0A994J5T6 A0A994J7P1 A0A994J7Q5 A0A994J819 A0A994J822 B5MCC5 B7Z2T4 E9PIJ9 E9PN83 Q15700
PDB IDs		5KC8 5KCA	2BYG 2HE2
GO Terms Enriched among Interactors		Glutamate-gated Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Postsynaptic Density Synapse Postsynaptic Density Membrane Regulation Of Presynaptic Membrane Potential Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Negative Regulation Of Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Complex Receptor Clustering Glutamate Receptor Signaling Pathway Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Localization Within Membrane Glutamate Receptor Binding Postsynaptic Membrane Glutamate-gated Calcium Ion Channel Activity Protein Localization To Membrane Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Long-term Synaptic Depression Postsynaptic Density, Intracellular Component Presynaptic Membrane Dendrite Monoatomic Ion Channel Activity Modulation Of Chemical Synaptic Transmission Neuronal Action Potential Regulation Of Synaptic Plasticity Cell-cell Signaling Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Hippocampal Mossy Fiber To CA3 Synapse Signaling Modulation Of Excitatory Postsynaptic Potential Cell Communication Cell Projection Signaling Receptor Activity Mossy Fiber Rosette Detection Of Cold Stimulus Involved In Thermoception Excitatory Postsynaptic Potential Extracellularly Glutamate-gated Ion Channel Activity Negative Regulation Of Anion Channel Activity Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Postsynaptic Density Membrane Synapse Glutamatergic Synapse Postsynaptic Membrane PDZ Domain Binding Regulation Of Membrane Potential Signaling Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Communication Synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Chemical Synaptic Transmission Postsynaptic Density Trans-synaptic Signaling Modulation Of Chemical Synaptic Transmission Metal Ion Transport Modulation Of Excitatory Postsynaptic Potential Cell-cell Signaling Glutamate Receptor Signaling Pathway Plasma Membrane Regulation Of System Process Protein Localization To Synapse Monoatomic Ion Transport Dendritic Spine Scaffold Protein Binding Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Signaling Regulation Of Cell Communication Regulation Of Synapse Organization Protein Localization To Cell Junction Presynapse Assembly Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Synapse Assembly Monoatomic Ion Channel Activity Inorganic Ion Transmembrane Transport NMDA Glutamate Receptor Activity Presynapse Organization Regulation Of Nervous System Process Calcium Ion Transport Synaptic Transmission, Glutamatergic