GRIA1 and TRPC1

Number of citations: 0 (PubMedID 14614461)
Data Source: HPRD (in vitro, in vivo)

		GRIA1	TRPC1
Name		glutamate ionotropic receptor AMPA type subunit 1	transient receptor potential cation channel subfamily C member 1
Structure
GO Annotations	Cellular Component	Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell-cell Junction Synaptic Vesicle Ionotropic Glutamate Receptor Complex External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Postsynaptic Density Membrane Dendrite Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuromuscular Junction Early Endosome Membrane Asymmetric Synapse AMPA Glutamate Receptor Complex Dendrite Membrane Dendritic Spine Membrane Neuronal Cell Body Membrane Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Somatodendritic Compartment Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Cell Body Axonal Spine Neuron Spine Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Synaptic Membrane Presynapse Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component Perisynaptic Space Proximal Dendrite	Plasma Membrane Membrane Cation Channel Complex Receptor Complex
	Molecular Function	Amyloid-beta Binding G-protein Alpha-subunit Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Adenylate Cyclase Binding Ligand-gated Monoatomic Ion Channel Activity Immunoglobulin Binding Protein Kinase Binding Protein Domain Specific Binding Glutamate-gated Calcium Ion Channel Activity PDZ Domain Binding Small GTPase Binding Myosin V Binding G-protein Beta-subunit Binding Beta-2 Adrenergic Receptor Binding Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding Protein Kinase A Binding Peptide Hormone Receptor Binding Scaffold Protein Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Signaling Receptor Binding Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Transmembrane Transporter Binding Metal Ion Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Regulation Of Receptor Recycling Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Synapse Assembly Long-term Memory Response To Xenobiotic Stimulus Response To Toxic Substance Response To Sucrose Response To Lithium Ion Positive Regulation Of Gene Expression Neuronal Action Potential Calcium-mediated Signaling Spinal Cord Development Cerebral Cortex Development Receptor Internalization Response To Nutrient Levels Response To Estradiol Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Cocaine Response To Morphine Response To Peptide Hormone Response To Ethanol Positive Regulation Of Membrane Potential Response To Arsenic-containing Substance Regulation Of Synaptic Plasticity Behavioral Response To Pain Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Response To Electrical Stimulus Regulation Of Postsynaptic Membrane Potential Long-term Synaptic Potentiation Long-term Synaptic Depression Response To Fungicide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To DsRNA Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Amine Stimulus Positive Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Presynaptic Membrane Potential Cellular Response To L-glutamate Cellular Response To Brain-derived Neurotrophic Factor Stimulus Conditioned Place Preference Response To Psychosocial Stress Positive Regulation Of Excitatory Postsynaptic Potential	Monoatomic Ion Transport Calcium Ion Transport Monoatomic Ion Transmembrane Transport Melanin Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Conduction
Pathways		COPII-mediated vesicle transport Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Cargo concentration in the ER Synaptic adhesion-like molecules Long-term potentiation	TRP channels Role of second messengers in netrin-1 signaling Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Glutamic acid Butabarbital Lamotrigine Isoflurane Ethanol Methoxyflurane Desflurane Sevoflurane Talampanel CX-717 CX516 Perampanel Tianeptine Fluciclovine (18F)	None
GWAS		Adult body size ( 32376654 ) Aging (time to event) ( 21782286 ) Anthropometric traits ( 19260139 ) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726 ) Chronotype ( 30696823 ) General risk tolerance (MTAG) ( 30643258 ) Hand grip strength ( 29691431 ) HDL cholesterol levels ( 32203549 ) Interleukin-6 levels ( 22205395 ) Middle childhood and early adolescence aggressive behavior ( 26087016 ) Morning person ( 30696823 ) Obesity-related traits ( 23251661 ) Post bronchodilator FEV1 in COPD ( 26634245 ) Schizophrenia ( 30285260 28991256 25056061 23974872 ) Sleep (1/3-day periodicity) ( 33075057 ) Sudden cardiac arrest ( 21658281 ) Survival in microsatellite instability low/stable colorectal cancer ( 25866641 )	No GWAS studies recorded
Interacting Genes		27 interacting genes: CACNG2 CAMK2A CAMK2G CANX CASP8 CXCR2 CYLD DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 NEDD4L PICK1 PRKACA PRKCA RPS6KB1 SDCBP SQSTM1 TANC1 TRPC1 USP46	14 interacting genes: BMPR2 CAV1 GRIA1 HOMER1 HOMER3 ITPR2 ITPR3 MDFI MX1 PKD2 RHOA TRPC3 TRPC4 TRPC5
Entrez ID		2890	7220
HPRD ID		00695	11894
Ensembl ID		ENSG00000155511	ENSG00000144935
Uniprot IDs		A0A9L9PXG3 P42261 Q59GL5	P48995
PDB IDs		6X5Q	8WPL 8WPM
GO Terms Enriched among Interactors		Synapse Modulation Of Chemical Synaptic Transmission Glutamatergic Synapse Regulation Of Protein Localization To Cell Periphery Postsynaptic Density Regulation Of Protein Localization Neuron Projection Regulation Of Cell Communication Regulation Of Signaling Endocytic Vesicle Membrane Ionotropic Glutamate Receptor Binding Regulation Of Transport Regulation Of Protein Localization To Membrane Regulation Of Biological Quality Postsynaptic Density Membrane Regulation Of Synaptic Plasticity Plasma Membrane Regulation Of Apoptotic Process Regulation Of Metal Ion Transport Regulation Of Programmed Cell Death Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission Regulation Of Monoatomic Ion Transport Positive Regulation Of Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization Intracellular Signaling Cassette Dendrite Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Programmed Cell Death Intracellular Protein Localization Proteolysis Involved In Protein Catabolic Process Proteolysis Chemical Synaptic Transmission AMPA Glutamate Receptor Complex Trans-synaptic Signaling Cortical Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Complex Regulation Of Cellular Localization Protein Phosphorylation Synaptic Signaling Establishment Of Protein Localization Protein Localization To Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Protein Localization To Postsynapse	Inositol 1,4,5 Trisphosphate Binding Calcium Channel Activity Calcium Ion Transport Cation Channel Complex Monoatomic Ion Channel Activity Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Response To Calcium Ion Store-operated Calcium Channel Activity Regulation Of Cytosolic Calcium Ion Concentration Response To Metal Ion Monoatomic Ion Transport Metal Ion Transport Plasma Membrane Intracellular Calcium Ion Homeostasis Regulation Of Monoatomic Ion Transport Inorganic Ion Homeostasis Regulation Of Calcium Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Dendrite Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity G Protein-coupled Glutamate Receptor Binding Transmembrane Transporter Binding Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Muscle Tissue Development Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Metal Ion Transport Endoplasmic Reticulum Membrane Calcium-mediated Signaling Glutamate Receptor Signaling Pathway Inorganic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Transmembrane Transport Intracellular Monoatomic Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Neuron Spine Regulation Of Vasoconstriction Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Caveola Intracellular Signaling Cassette Chemical Homeostasis Signal Transduction ATPase Binding Postsynaptic Density