GPR26 and HTR1A

Number of citations: 0 (PubMedID 11854302)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro, in vivo)

		GPR26	HTR1A
Name		G protein-coupled receptor 26	5-hydroxytryptamine receptor 1A
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane Dendrite Cell Projection Synapse
	Molecular Function	G Protein-coupled Receptor Activity	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Receptor-receptor Interaction Serotonin Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	Behavioral Fear Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Regulation Of Serotonin Secretion Regulation Of Vasoconstriction Exploration Behavior Regulation Of Dopamine Metabolic Process Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior
Pathways		None	Serotonin receptors
Drugs		None	Eletriptan Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Pramipexole Methylphenidate Imipramine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Propranolol Fenfluramine Lisuride Trazodone Sumatriptan Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Alprenolol Ondansetron Oxymetazoline Naratriptan Pindolol Dopamine Ergoloid mesylate Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Lysergic acid diethylamide Dapoxetine Bifeprunox Flibanserin Iloperidone Lofexidine Lesopitron Rotigotine MN-305 LI-301 Naluzotan Cariprazine Mianserin Pizotifen Asenapine Xaliproden Dotarizine Sarizotan Repinotan Robalzotan Vilazodone Bopindolol Cinitapride Lurasidone Perospirone Cannabidiol Vortioxetine Brexpiprazole Dosulepin Pirlindole Tianeptine Setiptiline Dihydroergocornine Tetrahydrocannabivarin Pardoprunox Gilteritinib Lecozotan Lecozotan Tiapride Dihydroergocristine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil SEP-363856 Serdexmethylphenidate
GWAS		Adult body size ( 32376654 ) Body mass index ( 28892062 ) Cardiac Troponin-T levels ( 23247143 ) Chronotype ( 30696823 ) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042 ) Hepcidin/ferritin ratio ( 27846281 ) Motion sickness ( 25628336 ) Night sleep phenotypes ( 27126917 ) Right lateral prefrontal cortical growth ( 29682794 )	Adult body size ( 32376654 ) Alcohol and nicotine co-dependence ( 23216389 ) Body mass index ( 20935630 ) Bronchopulmonary dysplasia ( 23897914 ) Daytime nap ( 33568662 ) Fasting insulin (dietary factor interaction) ( 24204828 ) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828 ) White matter lesion progression ( 26451028 ) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028 )
Interacting Genes		1 interacting genes: HTR1A	8 interacting genes: FGFR1 GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3
Entrez ID		2849	3350
HPRD ID		07275	00190
Ensembl ID		ENSG00000154478	ENSG00000178394
Uniprot IDs		Q8NDV2	A8K5W4 P08908 Q5ZGX3
PDB IDs		Not available	7E2X 7E2Y 7E2Z 8FY8 8FYE 8FYL 8FYT 8FYX 8JSP 8JT6 8PJK 8PKM 8W8B
GO Terms Enriched among Interactors		G Protein-coupled Serotonin Receptor Activity Regulation Of Serotonin Secretion Serotonin Metabolic Process Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Gi/o-coupled Serotonin Receptor Activity Serotonin Binding Serotonin Receptor Activity Serotonin Receptor Signaling Pathway Receptor-receptor Interaction Regulation Of Dopamine Metabolic Process Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Behavioral Fear Response Exploration Behavior Behavioral Defense Response Fear Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Vasoconstriction Multicellular Organismal Response To Stress Regulation Of Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phenol-containing Compound Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Circulation Regulation Of Hormone Secretion Vascular Process In Circulatory System Circulatory System Process Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling G Protein-coupled Receptor Activity Regulation Of Monoatomic Ion Transport	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Gi/o-coupled Serotonin Receptor Activity Sphingosine-1-phosphate Receptor Activity Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Signal Transduction G Protein-coupled Serotonin Receptor Activity Serotonin Receptor Activity Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Plasma Membrane Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Cell-cell Signaling Vasoconstriction Signaling Cell Communication G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Cardiac Muscle Tissue Growth Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Trans-synaptic Signaling Synaptic Signaling G Protein-coupled Receptor Binding Regulation Of Behavior Membrane Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Establishment Of Endothelial Barrier Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Lateral Mesodermal Cell Fate Specification Serotonergic Synapse Negative Regulation Of Serotonin Secretion G Protein-coupled GABA Receptor Complex G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Heterodimeric Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Ventricular Zone Neuroblast Division Regulation Of Mitotic Cell Cycle DNA Replication Orbitofrontal Cortex Development GABA Receptor Complex Sphingolipid Binding Growth Involved In Heart Morphogenesis Positive Regulation Of Chemotaxis