HEXD and ADPRS

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		HEXD	ADPRS
Name		hexosaminidase D	ADP-ribosylserine hydrolase
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Vesicle	Nucleus Nucleoplasm Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Nuclear Body Site Of DNA Damage
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-N-acetylhexosaminidase Activity Hexosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds	Magnesium Ion Binding Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Poly(ADP-ribose) Glycohydrolase Activity Protein Binding Hydrolase Activity Metal Ion Binding O-acetyl-ADP-ribose Deacetylase Activity ADP-ribosylserine Hydrolase Activity
	Biological Process	Carbohydrate Metabolic Process	DNA Repair Base-excision Repair, Gap-filling DNA Damage Response Negative Regulation Of Necroptotic Process Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation
Pathways		None	POLB-Dependent Long Patch Base Excision Repair
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		9 interacting genes: ADPRS C7orf25 EEF1D GDPD2 GLRX3 PRKN PSD RILPL2 TUBB3	5 interacting genes: FRA10AC1 HEXD HSPB1 PRDM5 TNKS
Entrez ID		284004	54936
HPRD ID		08677	12432
Ensembl ID		ENSG00000169660	ENSG00000116863
Uniprot IDs		Q8WVB3	B7ZAN4 Q9NX46
PDB IDs		Not available	2FOZ 2FP0 2G4K 5ZQY 6D36 6D3A 7AKR 7AKS 7ARW 7L9F 7L9H 7L9I
GO Terms Enriched among Interactors		Heat Shock Protein Binding Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Regulation Of Necroptotic Process Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Netrin Receptor Binding Glycerophosphoinositol Inositolphosphodiesterase Activity Poly(ADP-ribose) Glycohydrolase Activity ADP-ribosylserine Hydrolase Activity Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation Protein Transport From Ciliary Membrane To Plasma Membrane Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Glycerophosphodiester Phosphodiesterase Activity O-acetyl-ADP-ribose Deacetylase Activity Cytoplasmic Translational Elongation Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake Cell Projection Regulation Of Synaptic Vesicle Transport Dorsal Root Ganglion Development Response To Superoxide Protein De-ADP-ribosylation Free Ubiquitin Chain Polymerization Cellular Response To Dopamine Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Neurotransmitter Secretion	None