HEXD and GDPD2

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		HEXD	GDPD2
Name		hexosaminidase D	glycerophosphodiester phosphodiesterase domain containing 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Vesicle	Cytoplasm Cytoskeleton Actin Filament Plasma Membrane Membrane Lamellipodium
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-N-acetylhexosaminidase Activity Hexosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds	Phosphoric Diester Hydrolase Activity Glycerophosphodiester Phosphodiesterase Activity Hydrolase Activity Metal Ion Binding Glycerophosphoinositol Inositolphosphodiesterase Activity
	Biological Process	Carbohydrate Metabolic Process	Lipid Metabolic Process Actin Filament Organization Positive Regulation Of Osteoblast Differentiation
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		9 interacting genes: ADPRS C7orf25 EEF1D GDPD2 GLRX3 PRKN PSD RILPL2 TUBB3	5 interacting genes: ATP5F1C DRD2 FRA10AC1 HEXD SGSM2
Entrez ID		284004	54857
HPRD ID		08677	06528
Ensembl ID		ENSG00000169660	ENSG00000130055
Uniprot IDs		Q8WVB3	Q9HCC8
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Heat Shock Protein Binding Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Regulation Of Necroptotic Process Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Netrin Receptor Binding Glycerophosphoinositol Inositolphosphodiesterase Activity Poly(ADP-ribose) Glycohydrolase Activity ADP-ribosylserine Hydrolase Activity Cellular Response To Superoxide Peptidyl-serine ADP-deribosylation Protein Transport From Ciliary Membrane To Plasma Membrane Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Glycerophosphodiester Phosphodiesterase Activity O-acetyl-ADP-ribose Deacetylase Activity Cytoplasmic Translational Elongation Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Positive Regulation Of Neurotransmitter Uptake Cell Projection Regulation Of Synaptic Vesicle Transport Dorsal Root Ganglion Development Response To Superoxide Protein De-ADP-ribosylation Free Ubiquitin Chain Polymerization Cellular Response To Dopamine Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Neurotransmitter Secretion	Proton-transporting ATP Synthase Activity, Rotational Mechanism Negative Regulation Of Synaptic Transmission, Glutamatergic Auditory Behavior Cellular Response To Ethanol Response To Histamine Regulation Of Synapse Structural Plasticity Anatomical Structure Regression Dopamine Binding Regulation Of Renal Sodium Excretion Dopamine Neurotransmitter Receptor Activity Regulation Of Synapse Organization Cerebral Cortex GABAergic Interneuron Migration Negative Regulation Of Cellular Response To Hypoxia Regulation Of Developmental Growth Neurotransmitter Transport Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Complex Catecholamine Uptake Dopamine Uptake Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Adenohypophysis Development Negative Regulation Of Dephosphorylation Response To Inactivity Positive Regulation Of Renal Sodium Excretion Interneuron Migration Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Neuron Migration Negative Regulation Of Circadian Rhythm Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Grooming Behavior Hyaloid Vascular Plexus Regression Regulation Of Growth Hormone Secretion Dopaminergic Synapse Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Prepulse Inhibition Neuron-neuron Synaptic Transmission Interneuron Migration From The Subpallium To The Cortex Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Peristalsis Striatum Development Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Uptake Involved In Synaptic Transmission G Protein-coupled Receptor Internalization Heterotrimeric G-protein Binding