CCR10 and PRRC2A

Number of citations: 0 (PubMedID 14667819)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		CCR10	PRRC2A
Name		C-C motif chemokine receptor 10	proline rich coiled-coil 2A
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	RNA Binding Protein Binding
	Biological Process	Chemotaxis Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Cell Differentiation
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	None
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Adult body size ( 32376654 ) Age at first birth ( 34211149 ) Anxiety ( 33859377 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Childhood body mass index ( 33045005 ) Hand grip strength ( 29691431 ) Height ( 28552196 ) Hemoglobin levels ( 32327693 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Leukocyte telomere length ( 32109421 ) Malaria ( 31844061 ) Menopause (age at onset) ( 22267201 ) Metabolite levels ( 31628463 ) Platelet distribution width ( 32888494 ) Schizophrenia ( 23894747 ) Systolic blood pressure ( 30578418 ) Ulcerative colitis ( 28067908 ) Waist circumference ( 31928498 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		1 novel interactors: RAB5C	None recorded
Interacting Genes		10 interacting genes: ARPC3 CCL19 CCL2 CCL25 CCL27 CCL28 CCL7 CCR7 CXCL13 PRRC2A	32 interacting genes: ATN1 ATXN1 C1QBP CCR10 CEBPA CPSF1 DDX20 EIF3E EWSR1 FGA GANAB GORASP2 GRB2 HNRNPA1 HNRNPM IFT88 IMMT JUN MAD2L2 MAN2C1 NEIL3 P4HA2 PRMT2 PSMA3 QARS1 RBFOX1 RBM11 RERE RUNX1 SRPK2 SSR3 UBAP2L
Entrez ID		2826	7916
HPRD ID		02586	00807
Ensembl ID		ENSG00000184451	ENSG00000204469
Uniprot IDs		P46092	A0A1U9X974 A0A1U9X985 A0A1U9X998 A0A1U9X999 A0A1U9X9A9 P48634
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Chemokine Activity Myeloid Leukocyte Migration Leukocyte Chemotaxis Granulocyte Chemotaxis Granulocyte Migration Cell Chemotaxis Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Chemotaxis Chemokine-mediated Signaling Pathway Locomotion Cytokine Activity Regulation Of Leukocyte Migration Chemokine Receptor Binding Humoral Immune Response Inflammatory Response CCR10 Chemokine Receptor Binding Eosinophil Chemotaxis Cell Motility Eosinophil Migration CCR Chemokine Receptor Binding Positive Regulation Of Leukocyte Chemotaxis Mononuclear Cell Migration Cell Migration Killing Of Cells Of Another Organism Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration CXCR Chemokine Receptor Binding Cell Killing Immune Response Cytokine-mediated Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Regulation Of Chemotaxis Response To External Biotic Stimulus Cellular Response To Lipid Defense Response Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Mononuclear Cell Migration CCL19-activated CCR7 Signaling Pathway Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Cell Migration Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Motility Response To Lipopolysaccharide	Nucleoplasm RNA Binding MRNA Metabolic Process MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing RNA Metabolic Process Protein Domain Specific Binding Regulation Of MRNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Processing Negative Regulation Of Biosynthetic Process Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Nuclear Matrix Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Nucleolus Nucleus Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription By RNA Polymerase II Hydrolase Activity, Acting On Glycosyl Bonds Regulation Of MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Transcription Corepressor Activity Regulation Of Macromolecule Biosynthetic Process Poly(U) RNA Binding Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Hematopoietic Stem Cell Proliferation Alternative MRNA Splicing, Via Spliceosome MRNA Binding Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Macromolecule Biosynthetic Process Adrenergic Receptor Binding Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Blood Coagulation, Common Pathway Guanyl-nucleotide Exchange Factor Adaptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Histone H3R8 Methyltransferase Activity DNA Damage Response, Signal Transduction Resulting In Transcription