GOT1 and PC

Number of citations: 0 (PubMedID 8349677)
Data Source: BioGRID (pull down)

		GOT1	PC
Name		glutamic-oxaloacetic transaminase 1	pyruvate carboxylase
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Axon Terminus Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Catalytic Activity L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Protein Binding Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine Transaminase Activity	Nucleotide Binding Catalytic Activity Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Amino Acid Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process L-aspartate Catabolic Process Glutamate Metabolic Process Notch Signaling Pathway Amino Acid Biosynthetic Process Response To Carbohydrate L-glutamate Catabolic Process To Aspartate Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Immobilization Stress Malate-aspartate Shuttle Dicarboxylic Acid Metabolic Process Response To Cadmium Ion Response To Glucocorticoid Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Fatty Acid Homeostasis Transdifferentiation Cellular Response To Mechanical Stimulus L-glutamate Biosynthetic Process Response To Transition Metal Nanoparticle	Gluconeogenesis Lipid Metabolic Process NADP+ Metabolic Process Negative Regulation Of Gene Expression Viral RNA Genome Packaging Viral Release From Host Cell NAD+ Metabolic Process Small Molecule Metabolic Process Host-mediated Activation Of Viral Process
Pathways		Methionine salvage pathway Aspartate and asparagine metabolism Malate-aspartate shuttle	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Gluconeogenesis Pyruvate metabolism
Drugs		Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine Adapalene Maleic acid Copper	Pyruvic acid Biotin 5-(hexahydro-2-oxo-1H-thieno[3,4-D]imidazol-6-yl)pentanal
Diseases		None	Pyruvate carboxylase deficiency
GWAS		Aspartate aminotransferase levels ( 21900944 30718733 ) Crohn's disease ( 22412388 ) Hypothyroidism ( 27182965 ) Liver enzyme levels (aspartate transaminase) ( 24124411 ) Mean corpuscular volume ( 29403010 ) Thyroid stimulating hormone levels ( 32769997 )	A body shape index ( 34021172 ) Bipolar disorder ( 21926972 31043756 34002096 ) Familial squamous cell lung carcinoma ( 29924316 ) Hip circumference adjusted for BMI ( 34021172 ) HIV-1 susceptibility ( 22174851 ) Urate levels ( 31578528 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 )
Interacting Genes		7 interacting genes: ABI3BP AGTR1 CCR2 EGFR PC SHANK3 TMEM120A	7 interacting genes: FNDC3B GOT1 GOT2 LCOR MDH2 RNF10 USP7
Entrez ID		2805	5091
HPRD ID		00687	02032
Ensembl ID		ENSG00000120053	ENSG00000173599
Uniprot IDs		A0A140VK69 P17174	P11498
PDB IDs		3II0 3WZF 6DNA 6DNB 6DND 6LIG	3BG3 3BG9 7WTA 7WTB 7WTC 7WTD 7WTE 8HWL 8J7O 8XL9
GO Terms Enriched among Interactors		Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway Biological Process Involved In Interaction With Host Positive Regulation Of Synaptic Transmission, Glutamatergic Intracellular Signaling Cassette Angiotensin Type I Receptor Activity Multivesicular Body, Internal Vesicle Lumen Pyruvate Carboxylase Activity Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Bradykinin Receptor Binding Shc-EGFR Complex Viral RNA Genome Packaging Guanylate Kinase-associated Protein Clustering Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Symbiont Entry Into Host Cell Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Cell Differentiation System Process Positive Regulation Of Inflammatory Response Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Binding Biotin Binding Coenzyme A Binding Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering Positive Regulation Of Synaptic Transmission CCR2 Chemokine Receptor Binding	Malate-aspartate Shuttle L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process L-aspartate Catabolic Process NAD+ Metabolic Process Aspartate Metabolic Process Oxaloacetate Metabolic Process L-glutamate Catabolic Process Dicarboxylic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process 2-oxoglutarate Metabolic Process Dicarboxylic Acid Catabolic Process Transaminase Activity Glutamate Metabolic Process Aspartate Family Amino Acid Metabolic Process Pyridoxal Phosphate Binding Gluconeogenesis Hexose Biosynthetic Process Glutamine Family Amino Acid Metabolic Process L-glutamate Biosynthetic Process L-malate Dehydrogenase (NADP+) Activity Upper Tip-link Density Myosin VII Complex Amino Acid Biosynthetic Process Catalytic Activity RNA Binding Purine Nucleotide Metabolic Process Proteinogenic Amino Acid Catabolic Process L-amino Acid Catabolic Process L-cysteine Transaminase Activity Phosphatidylserine Decarboxylase Activity Nucleotide Metabolic Process Amino Acid Catabolic Process Response To Transition Metal Nanoparticle L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Symbiont-mediated Disruption Of Host Cell PML Body Small Molecule Biosynthetic Process Carbohydrate Biosynthetic Process Glucose Metabolic Process Purine-containing Compound Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Phagolysosome Assembly Stereocilium Base Chondrocyte Development Involved In Endochondral Bone Morphogenesis Glycerol Biosynthetic Process Equilibrioception Postsynapse To Nucleus Signaling Pathway