GOLGA3 and GOPC

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro, two hybrid, in vivo)

		GOLGA3	GOPC
Name		golgin A3	golgi associated PDZ and coiled-coil motif containing
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Membrane Golgi Cisterna Membrane	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Trans-Golgi Network Transport Vesicle Dendrite Golgi-associated Vesicle Membrane Protein-containing Complex Cell Projection Synapse
	Molecular Function	Protein Binding Cadherin Binding	Protein Binding Identical Protein Binding Transmembrane Transporter Binding Molecular Sequestering Activity
	Biological Process	None	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Negative Regulation Of Anion Channel Activity Protein Transport Apical Protein Localization Negative Regulation Of Protein Localization To Cell Surface
Pathways		RND2 GTPase cycle	RHO GTPases regulate CFTR trafficking RHOQ GTPase cycle
GWAS		Basal metabolic rate ( 31453325 ) Basal metabolic rate variance ( 31453325 ) Body mass index ( 28552196 ) Immune response to smallpox vaccine (IL-6) ( 22542470 ) Refractive error ( 32231278 ) Smoking initiation ( 33082346 )	Atrial fibrillation ( 29892015 ) Colorectal cancer ( 23266556 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Facial emotion recognition (fearful faces) ( 28608620 ) Mild obesity-related type 2 diabetes ( 34737425 ) Night sleep phenotypes ( 27126917 )
Interacting Genes		10 interacting genes: ATXN7 CASP2 CASP3 CASP7 FXR1 GOLGA7 GOPC KCNJ1 OLIG2 TSNAX	71 interacting genes: ABCA1 ADRB1 AKIRIN1 ASIC3 BATF BECN1 C17orf67 CCDC102B CCDC198 CD300C CDKN2C CEBPA CERCAM CFTR CLCN3 CRHR1 CSPG5 DLEU1 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GEM GOLGA3 GRID1 GRID2 HCK HNRNPLL IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MYLK MYOCD NOTCH1 NUP62 OSBP2 PARK7 PID1 PPP1R18 PWWP3A RALGAPB RELA RHOQ RNF183 RNF220 RPL13AP17 RPS6KA1 RTKN SEMA4G SLC25A18 SNX31 SPATA8 SSTR5 STARD3 STX6 TGFBR2 UBE3A VIM VTN ZBTB49 ZDHHC1 ZNF564 ZNF581 ZNF587 ZNF835 ZSCAN1
Entrez ID		2802	57120
HPRD ID		03990	06024
Ensembl ID		ENSG00000090615	ENSG00000047932
Uniprot IDs		A0A8I5KWY9 Q08378	Q9HD26
PDB IDs		Not available	2DC2 2LOB 4E34 4E35 4JOE 4JOF 4JOG 4JOH 4JOJ 4JOK 4JOP 4JOR 4K6Y 4K72 4K75 4K76 4K78 4NMO 4NMP 4NMQ 4NMR 4NMS 4NMT 4NMV 4Q6H 4Q6S 5IC3 5K4F 6OV7 6V84 6XNJ 7JZO 7JZP 7JZQ 7JZR
GO Terms Enriched among Interactors		Execution Phase Of Apoptosis Cellular Response To Staurosporine Luteolysis Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Protein Poly-ADP-ribosylation Aspartic-type Endopeptidase Activity Cysteine-type Peptidase Activity Ovulation Cycle Process Protein Processing Cellular Response To Alkaloid Leukocyte Apoptotic Process Pyroptotic Inflammatory Response Mannose To Fructose-6-phosphate Catabolic Process Mannose-6-phosphate Isomerase Activity Negative Regulation Of Anion Channel Activity	Response To Lipid Phagocytic Vesicle PDZ Domain Binding Golgi-associated Vesicle Membrane Response To Xenobiotic Stimulus Positive Regulation Of Cellular Component Biogenesis Phagocytosis, Engulfment Response To Vitamin Negative Regulation Of Cell Population Proliferation Regeneration Liver Development Response To Hormone Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Positive Regulation Of Reactive Oxygen Species Metabolic Process Glutamatergic Synapse Transcription Factor AP-1 Complex Trans-synaptic Protein Complex AMPA Glutamate Receptor Activity Scaffold Protein Binding SMAD Protein Signal Transduction Postsynapse To Nucleus Signaling Pathway Response To Muramyl Dipeptide Membrane Hyperpolarization Negative Regulation Of Skeletal Muscle Cell Differentiation Myeloid Leukocyte Differentiation Hormone-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Stem Cell Proliferation Signal Transduction Organic Hydroxy Compound Transport Integrated Stress Response Signaling Synaptic Signaling Via Neuropeptide Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Adhesion Molecule Production