GOLGA2 and RAB2A

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (two hybrid, affinity chromatography technology), HPRD (in vitro, two hybrid)

		GOLGA2	RAB2A
Name		golgin A2	RAB2A, member RAS oncogene family
Structure
GO Annotations	Cellular Component	Golgi Cis Cisterna Golgi Membrane Spindle Pole Cytoplasm Golgi Apparatus Cis-Golgi Network Cytoskeleton Microtubule Membrane COPII-coated ER To Golgi Transport Vesicle Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Mitotic Spindle	Golgi Membrane Autophagosome Membrane Acrosomal Vesicle Nucleus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Extracellular Exosome
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding Syntaxin Binding Identical Protein Binding Cadherin Binding Importin-alpha Family Protein Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding
	Biological Process	Protein Glycosylation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule Nucleation Golgi Organization Centrosome Cycle Asymmetric Cell Division Negative Regulation Of Autophagy Protein Transport Negative Regulation Of Protein Binding Spindle Assembly Protein Homotetramerization Cell Division Positive Regulation Of Protein Glycosylation Golgi Ribbon Formation Golgi Disassembly Meiotic Spindle Assembly Mitotic Spindle Assembly	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Vesicle-mediated Transport Macroautophagy Autophagosome-lysosome Fusion
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Golgi Cisternae Pericentriolar Stack Reorganization RAB geranylgeranylation
GWAS		Adult body size ( 32376654 ) Body mass index ( 26426971 )	Aspartate aminotransferase levels ( 33547301 ) Autoimmune thyroid disease ( 32581359 ) Estimated glomerular filtration rate ( 31152163 ) Low density lipoprotein cholesterol levels ( 32154731 ) Neutrophil count ( 32888494 ) Systemic sclerosis ( 31672989 ) Total cholesterol levels ( 29083408 )
Interacting Genes		465 interacting genes: ABHD17A ABLIM1 ADAP1 AFF4 AIRIM ALKBH2 ALKBH3 AMOTL2 ANKHD1 ANKRD11 ANKRD36 ANKRD36BP1 ANKS1A APC AQP1 ARFIP2 ARHGAP45 ARHGEF6 ARID5A ARL16 ARL4A ARNT2 ARPC3 ATOSA ATOSB ATP5PO ATP6V1C2 ATP6V1D ATP6V1G1 ATXN7 AXIN1 BAHD1 BARD1 BAZ2B BCAS2 BCL6 BCL6B BMS1P1 BYSL C12orf50 C19orf44 C1orf35 CAB39 CAPN7 CATSPERT CBX8 CBY2 CCAR1 CCDC120 CCDC13 CCDC146 CCDC150 CCDC17 CCDC185 CCDC187 CCDC198 CCDC70 CCDC87 CCDC92 CCHCR1 CCNC CCNH CDC20B CDC37 CDC5L CDC7 CDC73 CDCA7L CDK1 CDK18 CDKL3 CDKN1A CENPP CEP55 CEP57L1 CEP95 CHCHD2 CHCHD3 CIC CINP CKB CLIP3 COG6 CORO1A COX5B CRACR2A CRMP1 CSPP1 CSTF2T CUL5 CWF19L2 CYB5R2 DAXX DCTN4 DCX DDX6 DEUP1 DGCR6 DLG4 DLGAP3 DLGAP5 DLX6-AS1 DMTN DNM2 DRC4 DTX2 DVL2 EAF2 EFCAB6 EFHC1 EGR2 EIF3G EIF4A2 ENKD1 ENPP7 EP300 ERCC3 ESCO2 EXOC8 EXOSC5 FAM110A FAM124B FAM161A FAM161B FAM184A FAM193B FAM50B FAM90A1 FANCG FBF1 FBXL18 FBXO28 FIP1L1 FNDC11 FOXC2 FOXP1 FXR1 FXR2 GADD45GIP1 GAS2L2 GATA1 GATA2 GATAD2B GCC1 GEM GFAP GGA2 GGN GLYCTK GMCL1 GNG5 GNL3L GORASP1 GORASP2 GPANK1 GPKOW GPS2 GRAP2 GRB14 GSE1 GTPBP10 GZMA GZMK HAUS1 HDAC4 HGS HOXB5 HOXB9 HTRA1 HYCC2 HYLS1 IFT20 IFT27 IGFN1 IHO1 IKZF3 IL16 INPP5J IQCE IQUB ISCU ITGB5 ITPKB ITSN2 KANK2 KANSL1 KAT5 KDM1A KIAA1217 KIFC3 KRT1 KRT18 KRT6A KRT6B KRT6C KRT75 L3MBTL2 LASP1 LATS1 LCOR LCP2 LENG1 LGALS3 LHX4 LIMS2 LIN7A LINGO1 LMNB2 LMO1 LMO2 LMO3 LMO4 LYPLA1 LYSMD1 MAB21L2 MAGOH MAGOHB MBD3 MCM10 MCM7 MCRS1 MFAP1 MID2 MISP MNAT1 MORF4L1 MORF4L2 MORN3 MOS MSRB3 MTFR2 MVP MYEF2 NCF2 NDC80 NDE1 NDEL1 NDN NDUFA5 NEBL NECAB2 NEFL NME7 NOS3 NOTCH1 NSMF NTAQ1 NUDT21 NXT2 OAS1 ODAD4 ORC1 PACRGL PARD6B PATL1 PCM1 PIAS2 PIBF1 PID1 PIK3R2 PIMREG PIN1 PITX1 PKN1 PKN3 PKP1 PKP2 PKP4 PLAAT5 PLEKHA2 POLDIP3 POLR3C POM121 POU4F3 PPP1R16B PPP1R18 PPP2CA PQBP1 PRAM1 PRKAA1 PRKAA2 PRKAB2 PRPF18 PRPF3 PRPF31 PSMA1 PSMA4 PTBP2 PTPN11 PTPN21 RAB1A RAB1B RAB2A RAB2B RAB33B RAB39A RAB39B RAB6A RAD18 RAMAC RANBP3 RANBP3L RBL1 RBM17 RBM22 RBM25 RBM39 RBM41 RCL1 RCOR3 RGS8 RHNO1 RHOJ RIBC1 RIN1 RITA1 RNF135 RNF169 RNF213 RNF214 RNF6 RSPH14 RSRC2 RTP5 RUSC2 RXRB SAMD4A SAP30BP SAXO4 SCAF8 SCEL SCNM1 SECISBP2 SELENOV SFI1 SH2D4A SH3GLB2 SH3RF2 SHC3 SHISA6 SLU7 SLX9 SMARCB1 SMARCE1 SMCP SMG9 SNAP47 SNF8 SNRPB SNRPB2 SNRPC SNTA1 SNW1 SNX18 SORBS2 SPATA18 SPATA2 SPATA22 SPG21 SRSF2 SSX2IP STAC STAMBPL1 STK25 STK26 STN1 SUDS3 SUGP2 SUPT5H SYNPO2L SYT17 SYT6 TBC1D22B TBC1D30 TBP TCEA2 TCEANC TCF19 TCL1A TDP2 TEAD4 TEPSIN TEX9 TFAP4 TFIP11 THAP7 THYN1 TLE5 TMED2 TPM1 TPRX1 TPX2 TRAF1 TRAF3IP2 TRAF4 TRAF5 TRIM14 TRIM29 TRIM42 TSC1 TSC22D4 TSGA10 TSGA10IP TSHZ2 TSHZ3 TSSC4 TSSK3 TTC23 TTC9C TTPA TUBGCP4 TXLNA TXLNB UBE2H UBE2I UBE2U UBE3C UBTFL1 USO1 USP15 USP2 UTP14C UTP23 VPS28 VPS37C WASHC3 WHRN WT1 XIAP YJU2 YTHDC1 ZBTB16 ZBTB4 ZBTB42 ZC2HC1C ZFC3H1 ZFHX3 ZFP2 ZFYVE26 ZG16B ZGPAT ZMAT1 ZMAT2 ZNF124 ZNF250 ZNF280C ZNF3 ZNF35 ZNF410 ZNF414 ZNF417 ZNF438 ZNF48 ZNF488 ZNF512B ZNF524 ZNF572 ZNF581 ZNF587 ZNF594 ZNF648 ZNF688 ZNF774 ZNF835 ZZZ3	29 interacting genes: BLZF1 CBFB CCDC125 CEBPA CFL2 FAM114A1 FAM114A2 FRMD1 GAA GAPDH GARIN4 GARIN6 GDI2 GOLGA2 GORASP2 HES6 ICA1 MAPK6 MAPKAPK3 OTOS PMAIP1 PRKCI RBSN RGS2 SGSM2 STAMBPL1 TBC1D25 TMEM70 TRIM7
Entrez ID		2801	5862
HPRD ID		03989	01539
Ensembl ID		ENSG00000167110	ENSG00000104388
Uniprot IDs		A0A8I5KNZ1 A0A8I5KZ68 A0A8I5QJQ7 A0A8J9BZL8 Q08379	P61019
PDB IDs		4REY 6IW8 6IWA 6K06	1Z0A
GO Terms Enriched among Interactors		Protein Binding Nucleus Nucleoplasm Centrosome Cytoskeleton Spliceosomal Complex Nuclear Speck MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Cytoplasm MRNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Organelle Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Androgen Receptor Binding RNA Metabolic Process Microtubule-based Process Zinc Ion Binding Regulation Of Primary Metabolic Process Spindle Pole Regulation Of Transcription By RNA Polymerase II Ciliary Basal Body Cytoskeleton Organization Centriole Organelle Assembly Negative Regulation Of RNA Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nuclear Export Regulation Of Macromolecule Metabolic Process Microtubule Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Intermediate Filament Organization Intermediate Filament Bundle Assembly Regulation Of Gene Expression Regulation Of Metabolic Process RNA Processing Negative Regulation Of Macromolecule Metabolic Process Cilium Organization Nucleobase-containing Compound Metabolic Process Golgi Organization U2-type Catalytic Step 2 Spliceosome	None