GNG7 and GNB4

Number of citations: 172 (PubMedID 40437099)
Data Source: BioGRID (cross-linking study), HPRD (two hybrid)

		GNG7	GNB4
Name		G protein subunit gamma 7	G protein subunit beta 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane Synapse Extracellular Exosome	Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Synapse Extracellular Exosome
	Molecular Function	Protein Binding G-protein Beta-subunit Binding	Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding
	Biological Process	Behavioral Fear Response Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Substantia Nigra Development
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GWAS		Chronotype ( 30696823 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 30598549 ) Neutrophil count ( 32888494 ) Thyroid stimulating hormone levels ( 32769997 )	Atrial fibrillation ( 29892015 30061737 ) Heart rate ( 23583979 ) Resting heart rate ( 27798624 29769521 )
Interacting Genes		8 interacting genes: ACP6 GNB1 GNB2 GNB3 GNB4 GNB5 GORASP2 MPP3	18 interacting genes: GNAI1 GNAI2 GNAI3 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 GNGT2 MTNR1A MTNR1B PTEN UBC
Entrez ID		2788	59345
HPRD ID		10376	09973
Ensembl ID		ENSG00000176533	ENSG00000114450
Uniprot IDs		O60262	Q9HAV0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex GTPase Binding GTPase Activity G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Protein-containing Complex Binding Lysosomal Membrane Synapse GTPase Activator Complex G-protein Gamma-subunit Binding Dark Adaptation Lysobisphosphatidic Acid Metabolic Process Light Adaption Regulation Of Locomotion Involved In Locomotory Behavior Acid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Cell Tip	Heterotrimeric G-protein Complex G-protein Beta-subunit Binding G Protein-coupled Receptor Signaling Pathway GTPase Activity Plasma Membrane Signal Transduction Guanyl Nucleotide Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Membrane Synapse Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Melatonin Receptor Activity Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Receptor Binding PDZ Domain Binding Extracellular Exosome Response To Prostaglandin E Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion By Cell Regulation Of G Protein-coupled Receptor Signaling Pathway Reproductive Behavior Negative Regulation Of Secretion Phototransduction Negative Regulation Of Insulin Secretion Midbody Negative Regulation Of Transport Negative Regulation Of Peptide Secretion Negative Regulation Of Synaptic Vesicle Clustering G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Detection Of Light Stimulus Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Hormone Secretion Multicellular Organismal Response To Stress Negative Regulation Of Protein Secretion Regulation Of Vascular Associated Smooth Muscle Cell Proliferation D2 Dopamine Receptor Binding GDP Binding Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Cell Body Ciliary Basal Body Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep