GNG5 and GNB3

Number of citations: 0 (PubMedID 8636150)
Data Source: HPRD (two hybrid)

		GNG5	GNB3
Name		G protein subunit gamma 5	G protein subunit beta 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Exosome	Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding PDZ Domain Binding G-protein Beta-subunit Binding	GTPase Activity Protein Binding Signaling Receptor Complex Adaptor Activity Spectrin Binding GTPase Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway	Cell Volume Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Hormone Metabolic Process Regulation Of Fat Cell Differentiation Regulation Of Feeding Behavior Regulation Of Cholesterol Metabolic Process Regulation Of Triglyceride Metabolic Process Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Phospholipid Metabolic Process
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production Sensory perception of sweet, bitter, and umami (glutamate) taste Sensory perception of sweet, bitter, and umami (glutamate) taste High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GWAS		No GWAS studies recorded	Central retinal vein equivalent ( 26567291 ) High myopia ( 31816047 33830181 ) Macular thickness ( 30535121 ) Myopia ( 27182965 ) Refractive error ( 32231278 ) Response to Vitamin E supplementation ( 22437554 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 )
Interacting Genes		12 interacting genes: AMOTL2 EPS15L1 GNB1 GNB2 GNB3 GNB4 GNB5 GOLGA2 KRT31 KRT40 MDFI TRAF1	11 interacting genes: CIDEB GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNG8 GRK2 RASD2 TGFBR1
Entrez ID		2787	2784
HPRD ID		11865	00743
Ensembl ID		ENSG00000174021	ENSG00000111664
Uniprot IDs		P63218	E9PCP0 F1T0G5 P16520
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex GTPase Binding GTPase Activity G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cytosol Extracellular Exosome Cytoskeleton Organization GTPase Activator Complex G-protein Gamma-subunit Binding Structural Constituent Of Skin Epidermis	G-protein Beta-subunit Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Signaling Pathway Synapse Signal Transduction Membrane GTPase Activity Plasma Membrane Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Zymogen Binding Cellular Response To Pheromone Edg-2 Lysophosphatidic Acid Receptor Binding PDZ Domain Binding Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Response To Pheromone