PCLO and GIT1

Number of citations: 0 (PubMedID 12473661)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo, in vitro, two hybrid)

		PCLO	GIT1
Name		piccolo presynaptic cytomatrix protein	GIT ArfGAP 1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Postsynaptic Density Axon Cell Projection Organelle Synapse Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse	Spindle Pole Cytoplasm Mitochondrion Endosome Centrosome Cytosol Cytoskeleton Focal Adhesion Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Cell Projection Neuron Projection Calyx Of Held Synapse Excitatory Synapse Inhibitory Synapse Anchoring Junction Mitotic Spindle Pole Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding Zinc Ion Binding Metal Ion Binding Structural Constituent Of Presynaptic Active Zone	GTPase Activator Activity Protein Binding Zinc Ion Binding Protein Phosphatase Binding Small GTPase Binding Identical Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Specialization Protein Tyrosine Kinase Binding
	Biological Process	Cytoskeleton Organization Synaptic Vesicle Exocytosis Regulation Of Exocytosis Insulin Secretion Protein Localization To Synapse Maintenance Of Presynaptic Active Zone Structure Regulation Of Transport Regulation Of Biological Quality Synaptic Vesicle Clustering Presynaptic Actin Cytoskeleton Organization Presynapse Organization Presynaptic Active Zone Assembly	Immunological Synapse Formation Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of ARF Protein Signal Transduction Negative Regulation Of ARF Protein Signal Transduction Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Synaptic Vesicle Recycling Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Dendritic Spine Development Motor Learning Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Microtubule Nucleation Maintenance Of Postsynaptic Specialization Structure Presynaptic Modulation Of Chemical Synaptic Transmission Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Receptor Catabolic Process
Pathways		Sensory processing of sound by inner hair cells of the cochlea	Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Energy expenditure (24h) ( 28476931 ) Grapefruit juice consumption ( 31046077 ) HDL cholesterol levels in HIV infection ( 33109212 ) Major depressive disorder ( 20351715 21621269 28540843 ) Metabolite levels ( 23823483 ) Nicotine dependence and major depression (severity of comorbidity) ( 30287806 ) Refractive error ( 32231278 ) Rosacea symptom severity ( 29771307 ) Schizophrenia ( 33169155 )	Adult body size ( 32376654 ) Brain morphology (MOSTest) ( 32665545 )
Interacting Genes		6 interacting genes: ERC2 GIT1 GIT2 PCAT1 SNCA TMEM132D	54 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CENPU CEP126 CFAP263 CHD3 DDX24 DSCR9 EIF6 ENTR1 GIT2 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HSPA13 HTT KIF1A KLHL4 LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG
Entrez ID		27445	28964
HPRD ID		16078	06577
Ensembl ID		ENSG00000186472	ENSG00000108262
Uniprot IDs		Q9Y6V0	Q59FC3 Q9Y2X7
PDB IDs		1UJD	Not available
GO Terms Enriched among Interactors		Presynapse Regulation Of G Protein-coupled Receptor Signaling Pathway Synaptic Vesicle Priming Growth Cone Synaptic Vesicle Recycling Regulation Of ARF Protein Signal Transduction Maintenance Of Synapse Structure Regulation Of Vesicle Fusion Synapse Organization Synapse Cell Junction Maintenance Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Neurotransmitter Secretion Positive Regulation Of SNARE Complex Assembly Regulation Of Microtubule Polymerization Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cell Junction Organization Cellular Component Maintenance Negative Regulation Of ARF Protein Signal Transduction Regulation Of Microtubule Polymerization Or Depolymerization GABA-ergic Synapse Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Vesicle-mediated Transport Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion Structural Constituent Of Postsynaptic Specialization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Regulation Of Exocytosis Locomotory Behavior Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein-containing Complex Assembly Intramembranous Ossification Response To Iron(II) Ion Calcium Ion Homeostasis Structural Constituent Of Presynaptic Active Zone Motor Learning Regulation Of Chaperone-mediated Autophagy Postsynapse Regulation Of Dopamine Uptake Involved In Synaptic Transmission	Beta-adrenergic Receptor Kinase Activity G Protein-coupled Receptor Kinase Activity Cytoplasm Presynaptic Active Zone Focal Adhesion Cell Projection Epidermal Growth Factor Receptor Signaling Pathway Signal Complex Assembly Cytoskeleton Cytosol ERBB Signaling Pathway Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Synapse Centrosome Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Localization Transforming Growth Factor Beta Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Kinase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Kinase Activity Vesicle Cytoskeletal Trafficking Positive Regulation Of Calcium Ion Transmembrane Transport Vesicle Localization Protein Autophosphorylation Centriolar Satellite ATP Binding Cell Junction Organization Desensitization Of G Protein-coupled Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-substrate Adhesion Protein-containing Complex Cellular Response To Fluid Shear Stress Synapse Organization Positive Regulation Of Cilium Assembly Negative Adaptation Of Signaling Pathway Positive Regulation Of Lamellipodium Morphogenesis Establishment Of Organelle Localization Positive Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Protein Phosphatase Binding Tachykinin Receptor Signaling Pathway Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Projection Organization