HTRA2 and AREL1

Number of citations: 30 (PubMedID 23479728)
Data Source: BioGRID (affinity chromatography technology, enzymatic study)

		HTRA2	AREL1
Name		HtrA serine peptidase 2	apoptosis resistant E3 ubiquitin protein ligase 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Membrane Mitochondrial Membrane Protein-containing Complex CD40 Receptor Complex Serine-type Endopeptidase Complex	Cytoplasm Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Unfolded Protein Binding Ubiquitin Ligase Inhibitor Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Proteolysis Ceramide Metabolic Process Apoptotic Process Mitochondrion Organization Adult Walking Behavior Adult Locomotory Behavior Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Herbicide Programmed Cell Death Protein Autoprocessing Pentacyclic Triterpenoid Metabolic Process Protein Catabolic Process Forebrain Development Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Interferon-beta Intracellular Signal Transduction Mitochondrial Protein Catabolic Process Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Neuron Development Neuron Apoptotic Process Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Type 2 Mitophagy Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Regulation Of Inflammatory Response Protein K11-linked Ubiquitination Protein K33-linked Ubiquitination
Pathways		Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)	Antigen processing: Ubiquitination & Proteasome degradation
Diseases		Parkinson's disease (PD)	None
GWAS		No GWAS studies recorded	General factor of neuroticism ( 30867560 ) Glaucoma (primary open-angle) ( 33627673 ) Mood instability ( 29187730 )
Interacting Genes		41 interacting genes: ACTA1 ALDH1A2 APC APP AREL1 BIRC2 BIRC3 BIRC6 BIRC7 CAD CCAR2 CDK1 CDK5 CSN1S1 CSN2 DIABLO EEF1A1 EIF4G1 HSD17B10 IMMT ITGA7 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MUL1 PAG1 PDXDC1 PDXDC2P-NPIPB14P PEA15 TRIM28 TUBA1A TUBB TUBB6 TUBB7P UBC USP7 VIM VPS4B XIAP	10 interacting genes: CRKL DIABLO HTRA2 PIAS4 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3
Entrez ID		27429	9870
HPRD ID		05919	13794
Ensembl ID		ENSG00000115317	ENSG00000119682
Uniprot IDs		A0A384MDW9 A0A8Q3SIX7 O43464	A0A7P0T811 O15033
PDB IDs		1LCY 2PZD 5FHT 5M3N 5M3O 5TNY 5TNZ 5TO0 5TO1 5WYN 7VGE 8AUK 8E2K	6JX5 6LOH
GO Terms Enriched among Interactors		Cell Death Apoptotic Process Programmed Cell Death MAP Kinase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process MAPK Cascade Regulation Of Cell Cycle Ubiquitin-protein Transferase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Cytosol Intracellular Signal Transduction Ubiquitin Protein Ligase Activity Protein Kinase Activity Regulation Of Apoptotic Process Intracellular Signaling Cassette Structural Constituent Of Cytoskeleton Regulation Of Programmed Cell Death Response To Cytokine Response To Peptide Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Inflammatory Response Acetylcholine Receptor Activator Activity Cytoplasm Response To Light Stimulus Positive Regulation Of Post-translational Protein Modification Glial Cell Development Protein Serine Kinase Activity Post-translational Protein Modification Regulation Of Post-translational Protein Modification Nucleotide Binding P38MAPK Cascade Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Protein Serine/threonine Kinase Activity Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Growth Regulation Of Synapse Organization Response To Radiation DNA Damage Response Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Modification Process	Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Modification By Small Protein Conjugation Regulation Of Protein Targeting To Mitochondrion Post-translational Protein Modification Regulation Of Post-translational Protein Modification Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process CD40 Receptor Complex Macromolecule Catabolic Process Protein Polyubiquitination Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Proteolysis Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Apoptotic Process Cell Death Negative Regulation Of Cell Communication Regulation Of Protein Localization Programmed Cell Death Negative Regulation Of Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Cytosol Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Apoptotic Process Protein Modification Process Positive Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Pentacyclic Triterpenoid Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of BMP Signaling Pathway Catabolic Process Ubiquitin Protein Ligase Binding Protein Autoubiquitination Positive Regulation Of Establishment Of Protein Localization Helper T Cell Diapedesis Mitochondrial Intermembrane Space Negative Regulation Of Type 2 Mitophagy Limb Epidermis Development