GLRA2 and PSD

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		GLRA2	PSD
Name		glycine receptor alpha 2	pleckstrin and Sec7 domain containing
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Chloride Channel Complex Cell Projection Synapse Postsynaptic Membrane Glycinergic Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane	Plasma Membrane Postsynaptic Density Membrane Cleavage Furrow Ruffle Membrane Cell Projection Dendritic Spine Postsynaptic Density, Intracellular Component
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Glycine Binding Extracellularly Glycine-gated Chloride Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Glycine-gated Chloride Ion Channel Activity Metal Ion Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phospholipid Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Neuropeptide Signaling Pathway Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Cellular Response To Amino Acid Stimulus Cellular Response To Zinc Ion Cellular Response To Ethanol Chloride Transmembrane Transport	Signal Transduction Neuron Projection Development Regulation Of ARF Protein Signal Transduction
Pathways		Neurotransmitter receptors and postsynaptic signal transmission Neurotransmitter receptors and postsynaptic signal transmission	None
Drugs		Glycine Lindane Picrotoxin Ethanol Memantine Taurine	None
GWAS		No GWAS studies recorded	Apolipoprotein B levels ( 32203549 ) Prostate cancer ( 23535732 ) Refractive error ( 32231278 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		5 interacting genes: BAG6 DDX24 GDI2 PSD SEC23A	5 interacting genes: GLRA2 GMFG GNB5 HEXD RAB40C
Entrez ID		2742	5662
HPRD ID		02379	09085
Ensembl ID		ENSG00000101958	ENSG00000059915
Uniprot IDs		P23416	A5PKW4 Q86YI3
PDB IDs		5BKF 5BKG 7KUY 7L31	Not available
GO Terms Enriched among Interactors		Rab GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Localization To Cilium Mitotic DNA Replication Initiation Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Leading Strand Elongation Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Maintenance Of Unfolded Protein BAT3 Complex Alpha DNA Polymerase:primase Complex COPII-coated Vesicle Budding DNA Replication, Synthesis Of Primer	Glycine-gated Chloride Ion Channel Activity Extracellularly Glycine-gated Chloride Channel Activity Actin Filament Debranching GTPase Activator Complex G-protein Gamma-subunit Binding Light Adaption Dark Adaptation Hexosaminidase Activity Transmitter-gated Monoatomic Ion Channel Activity Beta-N-acetylhexosaminidase Activity Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Postsynaptic Membrane Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Glycinergic Synapse Negative Regulation Of Actin Nucleation Negative Regulation Of Voltage-gated Calcium Channel Activity Cell Tip Glycine Binding Cellular Response To Ethanol Actin Filament Severing Arp2/3 Complex Binding Regulation Of Voltage-gated Calcium Channel Activity GTPase Activity Response To Light Intensity Cul5-RING Ubiquitin Ligase Complex Lipid Droplet Formation Negative Regulation Of Focal Adhesion Assembly Cellular Response To Zinc Ion Parallel Fiber To Purkinje Cell Synapse G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Transporter Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds