BIN1 and ASAP2

Number of citations: 43 (PubMedID 15483625)
Data Source: HPRD (in vitro)

		BIN1	ASAP2
Name		bridging integrator 1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Actin Cytoskeleton Membrane Z Disc T-tubule Axon Dendrite I Band Vesicle Node Of Ranvier Axon Initial Segment Varicosity Axon Terminus Cerebellar Mossy Fiber Lipid Tube RNA Polymerase II Transcription Repressor Complex Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Golgi Cisterna Membrane
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Lipid Binding Aspartic-type Endopeptidase Inhibitor Activity Clathrin Binding Identical Protein Binding Protein-containing Complex Binding Tau Protein Binding Actin Filament Binding GTPase Binding Protein-folding Chaperone Binding RNA Polymerase Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Nucleus Organization Cytoskeleton Organization Endosome To Lysosome Transport Regulation Of Cell Cycle Process Regulation Of Endocytosis Cell Differentiation Positive Regulation Of Actin Filament Polymerization T-tubule Organization Positive Regulation Of Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Astrocyte Differentiation Establishment Of Localization In Cell Lipid Tube Assembly Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	None
Pathways		Clathrin-mediated endocytosis	None
Diseases		Centronuclear myopathy	None
GWAS		Alzheimer's disease ( 21460840 31473137 21627779 22832961 ) Alzheimer's disease (late onset) ( 28714976 30617256 21390209 21460841 24162737 ) Alzheimer's disease (onset between ages 58 and 79) ( 30979435 ) Alzheimer's disease in APOE e4+ carriers ( 25778476 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256 ) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Creatine kinase levels ( 29403010 ) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341 ) Family history of Alzheimer's disease ( 30617256 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 32888494 ) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411 ) Neurofibrillary tangles ( 25188341 ) Neutrophil count ( 32888494 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Psychosis and Alzheimer's disease ( 22005930 ) Systemic lupus erythematosus ( 24871463 )	Bipolar disorder ( 31043756 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic obstructive pulmonary disease ( 30804561 ) Chronic widespread musculoskeletal pain ( 33331911 ) Pulse pressure ( 27841878 30578418 ) Urate levels ( 31578528 )
Interacting Genes		48 interacting genes: ABL1 ACTA1 ACTG1 AMPH AP2A1 AP2A2 APP APPL1 ASAP2 ATXN2 CLIP1 CUX1 DLGAP4 DNM1 DNM2 E2F1 FBP1 FHL2 HUNK ITCH ITGA1 ITGA3 ITGA6 MAP4K3 MBNL1 MYC PDK1 PLD1 PLD2 PTGER4 PTK2 RAP1A RFX3 RIN2 RIN3 SH3GL2 SH3GLB1 SNAPIN SNX4 SOS1 SOS2 SYN1 SYNJ1 TP73 UBC WASL XRCC4 ZBTB3	14 interacting genes: APC ARF1 ARF5 ARF6 BIN1 GRB2 ITSN1 PACSIN3 PTK2B PXN RAN REPS2 SH3KBP1 THSD7A
Entrez ID		274	8853
HPRD ID		03150	04820
Ensembl ID		ENSG00000136717	ENSG00000151693
Uniprot IDs		B7Z2Z2 B7Z6Y2 O00499 Q9BTH3	O43150
PDB IDs		1MUZ 1MV0 1MV3 2FIC 2RMY 2RND 5I22	Not available
GO Terms Enriched among Interactors		Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport Endocytosis Vesicle-mediated Transport In Synapse Vesicle-mediated Transport Cytoplasmic Vesicle Import Into Cell Regulation Of Endocytosis Presynapse Synaptic Vesicle Endocytosis Regulation Of Plasma Membrane Organization Presynaptic Endocytosis Positive Regulation Of Cellular Component Organization Protein Kinase Binding Regulation Of Transport Regulation Of Receptor-mediated Endocytosis Receptor Internalization Clathrin-coated Pit Endocytic Vesicle Membrane Plasma Membrane Perinuclear Region Of Cytoplasm Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Hematopoietic Progenitor Cell Differentiation Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Vesicle Scission Negative Regulation Of Membrane Tubulation Integrin-mediated Signaling Pathway Cytosol Small GTPase-mediated Signal Transduction Receptor-mediated Endocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Establishment Of Localization In Cell Regulation Of Cell Projection Organization Regulation Of Vesicle Size Fc Receptor Signaling Pathway Glutamatergic Synapse Vesicle Localization Growth Cone Filopodium Cytoplasm Response To Growth Factor Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Early Endosome Cell Projection Organization Regulation Of Leukocyte Migration Fc Receptor Mediated Stimulatory Signaling Pathway Endocytic Vesicle Positive Regulation Of Cell Projection Organization Regulation Of Receptor Internalization	Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Endocytosis Positive Regulation Of Actin Filament Polymerization Vesicle-mediated Transport Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Import Into Cell Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Positive Regulation Of Protein Polymerization Plasma Membrane Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament Polymerization Synaptic Vesicle Endocytosis Regulation Of Endocytosis Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Presynaptic Endocytosis Cytosol Cell Cortex Lamellipodium Positive Regulation Of Cellular Component Organization Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Focal Adhesion Positive Regulation Of Protein-containing Complex Assembly Regulation Of Organelle Organization Intracellular Transport Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytoplasm ERBB Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Cellular Component Organization Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Glutamatergic Synapse Apical Dendrite Negative Regulation Of Monoatomic Ion Transport GTPase Activity Cellular Localization Establishment Of Localization In Cell Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transport Actin Cytoskeleton Organization Recycling Endosome GTP Binding