STK39 and SLC12A2

Number of citations: 0 (PubMedID 14563843)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		STK39	SLC12A2
Name		serine/threonine kinase 39	solute carrier family 12 member 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Cortex Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cell Body	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Membrane Cell Projection Membrane Cell Projection Neuron Projection Neuronal Cell Body Cell Body Cell Body Membrane Extracellular Exosome Cell Periphery Extracellular Vesicle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Transmembrane Transporter Binding Ion Channel Regulator Activity Protein Serine Kinase Activity Transporter Activator Activity Transporter Inhibitor Activity	Protein Binding Sodium:potassium:chloride Symporter Activity Ammonium Channel Activity Potassium Ion Transmembrane Transporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Protein-folding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Response To Dietary Excess Protein Phosphorylation Cell Volume Homeostasis Inflammatory Response Signal Transduction Regulation Of Blood Pressure Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Chloride Ion Homeostasis Negative Regulation Of Transmembrane Transport Intracellular Signal Transduction Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Maintenance Of Lens Transparency Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Macrophage Activation Positive Regulation Of Potassium Ion Transport Protein Autophosphorylation Regulation Of Inflammatory Response Monoatomic Ion Homeostasis Renal Sodium Ion Absorption Cellular Hyperosmotic Response Cellular Hypotonic Response Potassium Ion Transmembrane Transport Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of P38MAPK Cascade Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Import Across Plasma Membrane Response To Aldosterone Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Chemokine	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Chloride Transport Intracellular Sodium Ion Homeostasis Cell Volume Homeostasis Hyperosmotic Response Gamma-aminobutyric Acid Signaling Pathway T Cell Chemotaxis Intracellular Potassium Ion Homeostasis Transepithelial Chloride Transport Intracellular Chloride Ion Homeostasis Maintenance Of Blood-brain Barrier Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Positive Regulation Of Cell Volume Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transport Negative Regulation Of Vascular Wound Healing Transepithelial Ammonium Transport Ammonium Transmembrane Transport Inorganic Anion Import Across Plasma Membrane Inorganic Cation Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Regulation Of Spontaneous Synaptic Transmission Transport Across Blood-brain Barrier Chloride Transmembrane Transport Positive Regulation Of Aspartate Secretion Regulation Of Matrix Metallopeptidase Secretion Potassium Ion Import Across Plasma Membrane Cellular Response To Chemokine
Pathways		None	Cation-coupled Chloride cotransporters
Drugs		Fostamatinib	Torasemide Potassium chloride Bumetanide Quinethazone
GWAS		Blood pressure ( 19114657 ) Body mass index ( 28552196 28892062 ) Daytime nap ( 33568662 ) Macular thickness ( 30535121 ) Metabolite levels ( 23823483 ) Parkinson's disease ( 21292315 25064009 27182965 28892059 32201043 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Type 1 diabetes ( 32005708 ) Weight ( 28552196 )	Apolipoprotein A1 levels ( 32203549 ) Beard thickness ( 26926045 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125 ) HDL cholesterol levels ( 32203549 ) Height ( 25282103 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Ileal carcinoids ( 21139019 ) Immature fraction of reticulocytes ( 32888494 ) Pelvic organ prolapse ( 32184442 ) Red cell distribution width ( 28957414 ) Statin-induced myopathy ( 31220337 )
Interacting Genes		15 interacting genes: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 TMEM132D TSC22D2 WNK4	3 interacting genes: COMMD1 OXSR1 STK39
Entrez ID		27347	6558
HPRD ID		09627	06775
Ensembl ID		ENSG00000198648	ENSG00000064651
Uniprot IDs		A0A8V8TKT5 Q9UEW8	B7ZM24 P55011 Q53ZR1
PDB IDs		7O86	6PZT 7D10 7MXO 7N3N 7S1X 7S1Y 7S1Z 7SFL 7SMP 7ZGO 8STE 9C0E 9C0G 9C0H
GO Terms Enriched among Interactors		Monoatomic Anion Homeostasis Chloride Ion Homeostasis Chloride:monoatomic Cation Symporter Activity Sodium:potassium:chloride Symporter Activity Chloride Transport Potassium Ion Transmembrane Transporter Activity Cell Volume Homeostasis Potassium Ion Homeostasis Inorganic Anion Transport Monoatomic Anion Transport Potassium Ion Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Intracellular Chloride Ion Homeostasis Response To Osmotic Stress Regulation Of Cell Size Regulation Of Cellular Component Size Inorganic Cation Import Across Plasma Membrane Chloride Transmembrane Transport Symporter Activity Response To Dietary Excess Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Response To Muscle Stretch Protein Serine Kinase Activity Sodium Ion Transmembrane Transport Import Across Plasma Membrane Protein Serine/threonine Kinase Activity Maintenance Of Blood-brain Barrier Aggresome Inorganic Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transporter Activity Sodium Ion Transport Homeostatic Process Multicellular Organismal-level Homeostasis Renal Absorption Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of T-helper 2 Cell Activation Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Positive Regulation Of Cell Volume Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Aldosterone Secretion Protein Kinase Activity Regulation Of Cell-cell Adhesion MAPK Cascade Basolateral Plasma Membrane	Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Ion Channel Regulator Activity Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Cellular Hypotonic Response Potassium Channel Inhibitor Activity Negative Regulation Of Sodium Ion Transmembrane Transport Hypotonic Response Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Sodium Ion Transport Cellular Response To Chemokine Regulation Of T Cell Chemotaxis Cellular Hyperosmotic Response Positive Regulation Of Lymphocyte Chemotaxis Regulation Of Monoatomic Cation Transmembrane Transport Renal Sodium Ion Absorption Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of Lymphocyte Chemotaxis Hyperosmotic Response Regulation Of Metal Ion Transport Negative Regulation Of Potassium Ion Transport Positive Regulation Of T Cell Migration Cell Volume Homeostasis Regulation Of Monoatomic Ion Transport Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Transport Positive Regulation Of Lymphocyte Migration Renal Absorption Cellular Response To Osmotic Stress Regulation Of T Cell Migration Regulation Of Potassium Ion Transmembrane Transport Regulation Of Lymphocyte Migration Regulation Of Sodium Ion Transport Response To Osmotic Stress Chemokine-mediated Signaling Pathway Regulation Of Cell Size Regulation Of Potassium Ion Transport Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Renal System Process Protein Autophosphorylation Positive Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Cholesterol Import Transmembrane Transporter Binding Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration