ARHGEF16 and MAPK1IP1L

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		ARHGEF16	MAPK1IP1L
Name		Rho guanine nucleotide exchange factor 16	mitogen-activated protein kinase 1 interacting protein 1 like
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	None
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Cadherin Binding	Protein Binding
	Biological Process	Regulation Of Cdc42 Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Cell Chemotaxis Activation Of GTPase Activity Positive Regulation Of Protein Localization To Plasma Membrane	None
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RHOG GTPase cycle	None
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690 ) Response to statin therapy ( 20339536 )	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Leukoderma in response to rhododendrol ( 32558222 )
Interacting Genes		11 interacting genes: AKT1 CKAP5 HNRNPH1 LASP1 LMNA LNX1 MAGED1 MAPK1IP1L TAX1BP3 TFG YWHAQ	26 interacting genes: ARHGEF16 C1orf94 CEP55 DAZAP2 EIF3E EWSR1 FUBP1 HGS HNRNPUL1 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-3 LENG8 MAGED1 MSX2 PDCD6 RAMAC RBFOX2 SS18L1 SUMO1 SUMO1P1 TFG TIAL1 UBE2I VPS37C
Entrez ID		27237	93487
HPRD ID		12478	12647
Ensembl ID		ENSG00000130762	ENSG00000168175
Uniprot IDs		B3KTS4 Q5VV41	Q8NDC0
PDB IDs		1X6B	Not available
GO Terms Enriched among Interactors		Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Release Of Cytochrome C From Mitochondria Identical Protein Binding Regulation Of Protein Localization To Nucleus 14-3-3 Protein Binding Protein Localization To Nucleus Regulation Of Protein Localization To Cell Surface Negative Regulation Of Protein Localization Regulation Of Release Of Cytochrome C From Mitochondria Postsynapse Regulation Of TRNA Methylation Microtubule Plus End Polymerase	Transcription Factor Binding Ubiquitin-like Protein Ligase Binding PML Body Small Protein Activating Enzyme Binding PML Body Organization Protein Sumoylation Intermediate Filament Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway RNA Binding Protein Tag Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nuclear Body Organization Nucleus Organization COPII Vesicle Coating Presynaptic Cytosol Postsynaptic Cytosol Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endoplasmic Reticulum Exit Site Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Organization Multivesicular Body Assembly Vesicle Organization Vesicle Coating Late Endosome To Vacuole Transport SUMO Conjugating Enzyme Activity