ARHGEF16 and TFG

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		ARHGEF16	TFG
Name		Rho guanine nucleotide exchange factor 16	trafficking from ER to golgi regulator
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Endoplasmic Reticulum Cytosol Endoplasmic Reticulum Exit Site
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Cadherin Binding	Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Cdc42 Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Cell Chemotaxis Activation Of GTPase Activity Positive Regulation Of Protein Localization To Plasma Membrane	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction COPII Vesicle Coating
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RHOG GTPase cycle	COPII-mediated vesicle transport Signaling by ALK fusions and activated point mutants
Diseases		None	Thyroid cancer Non-small cell lung cancer
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690 ) Response to statin therapy ( 20339536 )	Refractive error ( 32231278 )
Interacting Genes		11 interacting genes: AKT1 CKAP5 HNRNPH1 LASP1 LMNA LNX1 MAGED1 MAPK1IP1L TAX1BP3 TFG YWHAQ	76 interacting genes: ACTMAP ANXA11 ARHGEF16 ARL15 BOLL BPIFA1 CEP126 CEP55 CFTR CRMP1 CRX CSTF2 DAZAP2 DVL3 ERG28 EWSR1 EYA2 FAM168A FOXH1 GBP2 GPRASP1 GRB2 HGS HNRNPF INCA1 INTS11 KHDC1 KRTAP26-1 LASP1 LENG8 MAGED1 MAPK1IP1L MED21 MED25 METTL27 MSS51 MYOT NADSYN1 NID2 OGT OXER1 PEF1 PFDN5 PIN1 PLA2G10 PLEKHG4 PLSCR1 POU2AF1 PRR20A PRR20B PRR20C PRR20D PRR20E PTPN6 RBPMS RIPPLY2 RNF4 SAXO4 SEC24A SF3A2 SF3B4 SMUG1 SNCA SPG21 SPMIP9 STAT5B STH TBX19 TRIM25 TSSK2 UBAP2 UBE2I VPS37C WWOX ZMYM5 ZNF34
Entrez ID		27237	10342
HPRD ID		12478	03932
Ensembl ID		ENSG00000130762	ENSG00000114354
Uniprot IDs		B3KTS4 Q5VV41	Q05BK6 Q92734
PDB IDs		1X6B	8TEQ 8TER 9E7C
GO Terms Enriched among Interactors		Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Negative Regulation Of Release Of Cytochrome C From Mitochondria Identical Protein Binding Regulation Of Protein Localization To Nucleus 14-3-3 Protein Binding Protein Localization To Nucleus Regulation Of Protein Localization To Cell Surface Negative Regulation Of Protein Localization Regulation Of Release Of Cytochrome C From Mitochondria Postsynapse Regulation Of TRNA Methylation Microtubule Plus End Polymerase	Protein Binding