IL37 and IL18BP

Number of citations: 27 (PubMedID 12381835)
Data Source: HPRD (in vitro)

		IL37	IL18BP
Name		interleukin 37	interleukin 18 binding protein
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Protein Binding Identical Protein Binding	Interleukin-18 Binding Receptor Antagonist Activity
	Biological Process	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Inflammatory Response Cellular Response To Lipopolysaccharide	Response To Lipopolysaccharide T-helper 1 Type Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor
Pathways		Interleukin-37 signaling Interleukin-18 signaling	Interleukin-37 signaling Interleukin-18 signaling
GWAS		Alanine aminotransferase levels ( 33547301 ) Dysmenorrheic pain severity ( 29855537 ) Menstruation quality of life impact (dysmenorrhea) ( 29855537 ) Pain medicine use during menstruation ( 29855537 ) Pulmonary function ( 23932459 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482 )	No GWAS studies recorded
Interacting Genes		8 interacting genes: CASP1 CASP4 IL18BP IL18R1 PRKAB2 SMAD3 TRIM55 TRIM63	2 interacting genes: IL18 IL37
Entrez ID		27178	10068
HPRD ID		05695	04984
Ensembl ID		ENSG00000125571	ENSG00000137496
Uniprot IDs		Q9NZH6	G3V1C5 O95998
PDB IDs		5HN1 6NCU	7AL7
GO Terms Enriched among Interactors		Interleukin-18-mediated Signaling Pathway Interleukin-18 Binding Immune System Process NLRP1 Inflammasome Complex Immune Response Response To External Biotic Stimulus Canonical Inflammasome Complex CARD Domain Binding Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Stress Protein Autoprocessing Response To Other Organism Defense Response Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Pyroptotic Inflammatory Response Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Signal Transduction Positive Regulation Of Cytokine-mediated Signaling Pathway Microtubule Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Signaling Cellular Response To Oxygen-containing Compound Cysteine-type Endopeptidase Activity Non-canonical Inflammasome Complex Negative Regulation Of Lung Blood Pressure Regulation Of Cardiac Muscle Hypertrophy Nuclear Mineralocorticoid Receptor Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Inflammatory Response AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Regulation Of Interleukin-1 Beta Production Positive Regulation Of Transforming Growth Factor Beta3 Production Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Localization To Extracellular Region Positive Regulation Of Cytokine Production AIM2 Inflammasome Complex Regulation Of Interleukin-1 Production IPAF Inflammasome Complex	Cytokine Activity Cellular Response To Molecule Of Bacterial Origin Interleukin-18 Receptor Binding Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Cytokine-mediated Signaling Pathway Inflammatory Response Positive Regulation Of NK T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Regulation Of Inflammatory Response Sleep Positive Regulation Of T-helper 1 Cell Cytokine Production Cellular Response To Lipid Positive Regulation Of Natural Killer Cell Proliferation T-helper 1 Type Immune Response Type 2 Immune Response Positive Regulation Of NK T Cell Activation Interleukin-1 Receptor Binding Interleukin-18-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-13 Production Regulation Of Natural Killer Cell Proliferation Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Cytokine Production Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Neuroinflammatory Response Regulation Of Defense Response Positive Regulation Of Type 2 Immune Response Response To Lipid Positive Regulation Of Tissue Remodeling Positive Regulation Of T-helper 1 Type Immune Response Cellular Response To Oxygen-containing Compound Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Interleukin-17 Production Negative Regulation Of Myoblast Differentiation Positive Regulation Of T-helper Cell Differentiation Neutrophil Activation Positive Regulation Of T Cell Cytokine Production Regulation Of Type 2 Immune Response Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Activated T Cell Proliferation Acylglycerol Homeostasis Immune Response Regulation Of Natural Killer Cell Activation