STK36 and MID1

Number of citations: 40 (PubMedID 25278022)
Data Source: BioGRID (affinity chromatography technology, enzymatic study)

		STK36	MID1
Name		serine/threonine kinase 36	midline 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Cell Projection	Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Microtubule Cytoskeleton Centriolar Satellite
	Molecular Function	Nucleotide Binding Transcription Corepressor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Phosphoprotein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Protein Phosphorylation Microtubule-based Process Smoothened Signaling Pathway Brain Development Post-embryonic Development Cell Projection Organization Axoneme Assembly Positive Regulation Of Smoothened Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Cilium Assembly	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Intracellular Signal Transduction
Pathways		None	Interferon gamma signaling
Drugs		Fostamatinib	None
Diseases		None	Opitz-GBBB syndrome
GWAS		Amyotrophic lateral sclerosis ( 22959728 ) Body mass index and triglycerides (pairwise) ( 33619380 ) Hematocrit ( 27863252 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Male-pattern baldness ( 28196072 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 )	No GWAS studies recorded
Interacting Genes		12 interacting genes: CDK5RAP2 CDK9 CLNK FRMPD4 GLI1 GLI2 GLI3 MAP1LC3B MAST2 MID1 NEIL3 SUFU	46 interacting genes: BYSL CDC37 CRY2 DYRK4 EHHADH ELOA EPN2 FAM50B FKBP1A GMCL1 HMG20B HTT IGBP1 KIF9 MEOX1 MID1IP1 MID2 N4BP1 OTUB2 PAX6 PDE4B PKN1 PPM1A PPP2CA PPP2CB PTCD2 PTPA RIC8A SPAG5 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2L6 UBE2N UBE2V1 UBE2W UBTD1 ZNF618
Entrez ID		27148	4281
HPRD ID		09631	02047
Ensembl ID		ENSG00000163482	ENSG00000101871
Uniprot IDs		A0A140VJW1 Q9NRP7	A0A087X255 A0A8I5KPE0 A0A8I5KR14 O15344
PDB IDs		Not available	2DQ5 2FFW 2JUN 5IM8 7QRY
GO Terms Enriched among Interactors		GLI-SUFU Complex Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Ciliary Base Spinal Cord Dorsal/ventral Patterning Ciliary Tip Dorsal/ventral Pattern Formation Smoothened Signaling Pathway Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Microtubule Binding Proximal/distal Pattern Formation Ventral Midline Development Double-stranded DNA Binding Hindgut Morphogenesis Pattern Specification Process Cerebellar Cortex Morphogenesis Regulation Of Smoothened Signaling Pathway Regionalization Tube Morphogenesis Lung Development Embryonic Digestive Tract Development Axoneme Osteoblast Differentiation Regulation Of Osteoblast Differentiation Pituitary Gland Development Negative Regulation Of Smoothened Signaling Pathway Mammary Gland Development Regulation Of Cell Differentiation Positive Regulation Of DNA Replication Artery Development Cilium Transcription Cis-regulatory Region Binding Notochord Regression Digestive Tract Development Lateral Semicircular Canal Development Sagittal Suture Morphogenesis Lambdoid Suture Morphogenesis Lateral Ganglionic Eminence Cell Proliferation Anterior Semicircular Canal Development Regulation Of Cellular Response To Drug Positive Regulation Of Cellular Response To Drug MCM Complex Binding Gland Development Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Ciliary Basal Body Negative Regulation Of Neuron Differentiation P-TEFb Complex Morphogenesis Of An Epithelium Semicircular Canal Development Mammary Gland Specification	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein K48-linked Ubiquitination Protein Ubiquitination Protein K11-linked Ubiquitination Protein Monoubiquitination ISG15 Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding ISG15-protein Conjugation Nucleus Nucleotide Binding Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Macromolecule Metabolic Process Transferase Activity Protein Phosphatase Type 2A Complex Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Protein Binding UBC13-MMS2 Complex Regulation Of Metabolic Process Regulation Of Gene Expression Phosphoprotein Phosphatase Activity Cytosol Ubiquitin Conjugating Enzyme Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Proteolysis Negative Regulation Of Signal Transduction Regulation Of Protein Polyubiquitination Regulation Of Microtubule-based Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Ubiquitin Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Primary Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Ligase Complex