PALD1 and ZBP1

Number of citations: 55 (PubMedID 21903422)
Data Source: BioGRID (pull down)

		PALD1	ZBP1
Name		phosphatase domain containing paladin 1	Z-DNA binding protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding	DNA Binding Left-handed Z-DNA Binding RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding Identical Protein Binding
	Biological Process	None	Activation Of Innate Immune Response Immune System Process Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Necroptotic Process Pyroptotic Inflammatory Response Necroptotic Signaling Pathway Execution Phase Of Necroptosis Antiviral Innate Immune Response Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		None	ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN RIP-mediated NFkB activation via ZBP1 Regulation of innate immune responses to cytosolic DNA Potential therapeutics for SARS
GWAS		Lymphocyte percentage of white cells ( 27863252 ) Superior frontal gyrus volume ( 31530798 ) Type 2 diabetes ( 30130595 )	Hippocampal atrophy ( 19668339 ) Response to fenofibrate (adiponectin levels) ( 23149075 ) Verbal declarative memory ( 25648963 )
Interacting Genes		2 interacting genes: IRF7 ZBP1	9 interacting genes: CTBP1 CTBP2 KLHL12 PALD1 PLXDC2 SIAH1 TRAF3 TRIM34 TRIP6
Entrez ID		27143	81030
HPRD ID		11419	09484
Ensembl ID		ENSG00000107719	ENSG00000124256
Uniprot IDs		A0A8V8TL18 Q9ULE6	Q9H171
PDB IDs		Not available	2L4M 2LNB 3EYI 4KA4
GO Terms Enriched among Interactors		Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Cytokine-mediated Signaling Pathway Left-handed Z-DNA Binding Activation Of Innate Immune Response Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Establishment Of Viral Latency Defense Response To Virus Positive Regulation Of Innate Immune Response Execution Phase Of Necroptosis MDA-5 Signaling Pathway Response To Virus Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Activation Of Immune Response Double-stranded RNA Adenosine Deaminase Activity Regulation Of Innate Immune Response Positive Regulation Of Defense Response Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Necroptotic Process Necroptotic Signaling Pathway Positive Regulation Of Programmed Necrotic Cell Death Regulation Of Interleukin-1-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Immune Response Defense Response To Symbiont Defense Response To Other Organism Regulation Of Monocyte Differentiation Regulation Of Defense Response Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Immune Response Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune System Process Regulation Of Necroptotic Process Regulation Of Myeloid Cell Apoptotic Process Response To Other Organism Regulation Of Programmed Necrotic Cell Death Immunoglobulin Mediated Immune Response Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Immune Response Pyroptotic Inflammatory Response B Cell Mediated Immunity Response To External Biotic Stimulus Type I Interferon-mediated Signaling Pathway Defense Response Defense Response To Fungus Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Apoptotic Process	Identical Protein Binding Viral Process White Fat Cell Differentiation Viral Genome Replication Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance NAD Binding Transcription Coregulator Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transcription Corepressor Binding Transcription Repressor Complex Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Ubiquitin Protein Ligase Activity Intermediate-density Lipoprotein Particle Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipoprotein Transport Negative Regulation Of Dendritic Spine Maintenance Very-low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Very-low-density Lipoprotein Particle Clearance Multivesicular Body, Internal Vesicle Positive Regulation Of Phospholipid Efflux Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Intracellular Signal Transduction AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Triglyceride-rich Lipoprotein Particle Clearance Positive Regulation Of Dendritic Spine Maintenance Regulation Of Plasma Lipoprotein Particle Levels Chylomicron Remnant Clearance Fat Cell Differentiation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Neurofibrillary Tangle Assembly Lipoprotein Biosynthetic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intracellular Signal Transduction Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Lipoprotein Particle Binding Virion Assembly