STAU2 and DHX58

Number of citations: 55 (PubMedID 21903422)
Data Source: BioGRID (pull down)

		STAU2	DHX58
Name		staufen double-stranded RNA binding protein 2	DExH-box helicase 58
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Microtubule Plasma Membrane Cytoplasmic Stress Granule Membrane Axon Dendrite Nuclear Membrane Dendrite Cytoplasm Protein-containing Complex Neuron Projection Neuronal Cell Body Dendritic Shaft Postsynapse Glutamatergic Synapse	Cytoplasm
	Molecular Function	RNA Binding Double-stranded RNA Binding MRNA Binding Protein Binding Kinesin Binding Hsp70 Protein Binding Ribosome Binding Mitogen-activated Protein Kinase Binding	Nucleotide Binding DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Germ Cell Development Intracellular MRNA Localization Regulation Of Actin Cytoskeleton Organization Cellular Response To Oxidative Stress Protein Localization To Synapse Eye Morphogenesis Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Positive Regulation Of Long-term Synaptic Depression	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Virus Response To Bacterium Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway
Pathways		None	DDX58/IFIH1-mediated induction of interferon-alpha/beta
GWAS		A body shape index ( 34021172 ) Alzheimer's disease (late onset) ( 30820047 ) Axial length ( 24144296 ) Malaria ( 31844061 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Refractive error ( 32231278 ) Urate levels in obese individuals ( 25811787 ) Waist circumference adjusted for body mass index ( 34021172 )	Coronary artery disease ( 29212778 ) Fasting plasma glucose ( 31932636 ) Mean spheric corpuscular volume ( 32888494 )
Interacting Genes		6 interacting genes: CEP126 DHX58 FOXP1 LINC00624 OGT RNF216	10 interacting genes: AGO2 AP2B1 APP DHX30 DICER1 EIF2AK2 EIF6 NKRF STAU2 TRIM14
Entrez ID		27067	79132
HPRD ID		09328	13115
Ensembl ID		ENSG00000040341	ENSG00000108771
Uniprot IDs		A8K276 Q9NUL3	A0AA51U9C6 Q96C10
PDB IDs		Not available	2RQA 2W4R 3EQT
GO Terms Enriched among Interactors		Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Gene Expression Negative Regulation Of Type I Interferon Production Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Hemopoiesis Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Interleukin-21 Production Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Osteoclast Development Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Regulation Of Type I Interferon Production Positive Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of MDA-5 Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway	Double-stranded RNA Binding RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Protein-RNA Complex Assembly RISC-loading Complex SiRNA Processing Post-transcriptional Regulation Of Gene Expression Translational Initiation RISC Complex Assembly SiRNA Binding Protein-containing Complex Assembly Pre-miRNA Processing Protein-containing Complex Organization Post-transcriptional Gene Silencing Regulation Of Translation RNA Binding MiRNA Metabolic Process Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Translation MiRNA Processing RNA Endonuclease Activity Nucleic Acid Binding Negative Regulation Of Gene Expression Dendritic Shaft Postsynapse Translation Initiation Factor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulatory RNA Binding Endoribonuclease Activity, Cleaving SiRNA-paired MRNA Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Clathrin-coated Pit Positive Regulation Of Chemokine Production Regulation Of ATP Metabolic Process Ribosome Binding Negative Regulation Of Viral Process Endonuclease Activity Nucleus Translation Cellular Component Assembly Axo-dendritic Transport