ANKRD1 and TRIM55

Number of citations: 46 (PubMedID 18157088)
Data Source: BioGRID (pull down)

		ANKRD1	TRIM55
Name		ankyrin repeat domain 1	tripartite motif containing 55
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Myofibril I Band Protein-containing Complex	Nucleus Cytoplasm Microtubule
	Molecular Function	P53 Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding	Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Sarcomere Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Phospholipase C/protein Kinase C Signal Transduction Negative Regulation Of DNA Biosynthetic Process	Leukocyte Migration Involved In Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction Innate Immune Response Diapedesis Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Macrophage Migration
Pathways		PPARA activates gene expression	None
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Intraocular pressure ( 29617998 ) Refractive error ( 32231278 )	Coronary heart disease event reduction (statin therapy interaction) ( 22666496 ) Metabolite levels ( 23823483 ) Recurrent major depressive disorder ( 29317602 )
Interacting Genes		23 interacting genes: APPL1 ARHGDIB ASH2L CASQ2 CDCA7L DNAJB6 DST DYSF LRPPRC MAPRE3 MEOX2 MYBPC1 MYL1 MYOM2 MYPN NAGK REPS1 SPANXN2 TRIM55 TRIM63 TTN TULP3 ZNF446	306 interacting genes: ACBD4 ACD ACTA1 ADAMTSL4 AEBP2 AFM AGO2 AKR1C8 ALKBH3 ANKRD1 ANKRD39 APLN APOBEC4 ARL6IP4 ATG4D ATP5F1B ATP5F1D ATXN3 ATXN3L ATXN7L1 BCAT1 BCHE BRAP BRD4 BRWD1 BTBD9 BYSL C10orf88 C1orf35 C3orf36 C8orf74 CADPS CAMK2A CAPN3 CARS1 CBX2 CCDC120 CCDC28B CDK3 CDS2 CENPK CHMP7 CKM COA7 COX4I1 CRCT1 CTAG1A CTAG1B CTNNB1 CTSF CYB5R2 CYP46A1 CYTOR DAPL1 DCAF11 DCAF6 DCTN3 DECR2 DEF8 DEK DES DNTTIP1 DOCK7 DYNLT2B EED EEF1G EHHADH EIF3E ELAPOR1 EPS8L2 ESPL1 EZH2 FAM185A FAM90A1 FANK1 FASTKD1 FERRY3 FHL2 FKBP6 FLNA FLNB FLNC FRMD6 FYN GABPB1 GATA3 GFM1 GLI4 GMEB1 GOLGA2P5 GPRIN2 GPS1 GRB10 GRB14 HID1 HIRA HOXA1 HROB ID1 IFI35 IGF2 IK IL37 ILF3 INCA1 ING4 INKA1 IQUB IRF2 IRF3 ITGB5 JADE3 KBTBD4 KCTD15 KIAA0087 KIAA0408 KIF13A KIF1B KIF5A KLHDC4 KLHL36 KMT2B KYAT1 LAGE3 LAMTOR5 LAPTM4A LIMS2 LINC00518 LINC00663 LINC00905 LINC01588 LMCD1 LMO2 LRRC56 LYN LYNX1 MAGEC3 MALSU1 MAP3K14 MBD4 MBIP MDM4 MIDN MIIP MKI67 MLH3 MLLT11 MPP1 MPZL1 MRPL19 MRPL20-AS1 MRPL41 MSRB3 MYBPC1 MYBPC3 MYBPHL MYCT1 MYOT MYOZ1 NDUFA1 NDUFA8 NEB NEBL NEFL NGEF NOMO1 NR1D2 NR2C2 NSD3 NSUN7 NUFIP2 ODF2 OGFOD2 OTUB1 OTUB2 P3H3 PACRGL PAFAH1B2 PCGF1 PCGF3 PCGF6 PELI3 PELO PHC2 PHF23 PIAS1 PIAS2 PIAS3 PIP4K2B PLEKHG4 PLXNA3 POLD1 POLR2E PPARA PPIE PRKAB2 PRKACA PRR30 PRRT1 PYGM RABEPK RAD23A RAI2 RBM14 RELA REX1BD RGR RHEB RHPN1 RING1 RNF10 RNF114 RPS4X RRAS RUSC1 RUSC1-AS1 SEC23B SET SHFL SLC6A13 SLFN12 SNW1 SPATS1 SPRYD7 SPSB1 SPSB2 SQSTM1 STAM SYMPK SYNCRIP TCAP TCP10L TEX19 THAP3 TIGD5 TIMM17B TMBIM1 TMEM35A TNIP3 TNNI1 TNNI2 TNNI3 TOR1AIP2 TPD52L3 TRAF3IP2 TRIB3 TRIM23 TRIM27 TRIM35 TRIM41 TRIM54 TRIM63 TRIM69 TRMT10B TSC2 TSC22D4 TTN TUBGCP4 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2L3 UCHL3 UCHL5 UNKL USP13 USP28 USP4 USP5 USP7 USP8 UXT VAC14 VPS37A WT1 XAGE1B YJU2B YOD1 YPEL3 ZBTB14 ZBTB17 ZC2HC1C ZC3H12A ZC3HC1 ZFYVE19 ZNF124 ZNF20 ZNF302 ZNF333 ZNF345 ZNF431 ZNF436 ZNF460 ZNF566 ZNF57 ZNF581 ZNF597 ZNF649 ZNF653 ZNF667-AS1 ZNF767P ZNF775 ZNF83 ZSCAN16
Entrez ID		27063	84675
HPRD ID		10647	05927
Ensembl ID		ENSG00000148677	ENSG00000147573
Uniprot IDs		A0A384NYH5 Q15327	Q9BYV6
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Z Disc M Band Sarcomere Organization Structural Constituent Of Muscle Muscle Contraction Actin Filament-based Process Actomyosin Structure Organization Muscle System Process Microtubule Actin Cytoskeleton Organization Calcium Ion Binding Titin Binding Contractile Muscle Fiber Muscle Filament Sliding Muscle Alpha-actinin Binding Cytoskeleton Organization Actin-myosin Filament Sliding Microtubule Plus-end Binding Negative Regulation Of Phagocytosis Myosin Filament Microtubule Plus-end I Band Calcium Ion Sequestering Activity Actin-mediated Cell Contraction Monocyte Activation Involved In Immune Response Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity Beta-tubulin Binding Cardiac Muscle Contraction Structural Molecule Activity H Zone Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Limb Development Myofibril Sarcomere Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Condensed Nuclear Chromosome Sarcomerogenesis Bronchus Morphogenesis Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process Positive Regulation Of Macropinocytosis N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation	Protein Binding Post-translational Protein Modification Cysteine-type Peptidase Activity Cysteine-type Deubiquitinase Activity Nucleus Protein Modification By Small Protein Conjugation Protein Deubiquitination Protein Modification By Small Protein Removal Z Disc Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Titin Binding Protein Ubiquitination Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Zinc Ion Binding Negative Regulation Of Metabolic Process Protein Modification Process Negative Regulation Of Transcription By RNA Polymerase II PRC1 Complex Sarcomere Organization Nucleoplasm Regulation Of RNA Metabolic Process Structural Constituent Of Muscle Contractile Muscle Fiber TORC1 Signaling TOR Signaling Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein K48-linked Deubiquitination PcG Protein Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of TORC1 Signaling K48-linked Deubiquitinase Activity Regulation Of Primary Metabolic Process Negative Regulation Of Protein Sumoylation Negative Regulation Of TORC1 Signaling Transcription Corepressor Activity Negative Regulation Of Translation Protein Metabolic Process Regulation Of Protein Sumoylation Negative Regulation Of Catabolic Process Sarcomere