COPG2 and PTGES3

Number of citations: 0 (PubMedID 11056392)
Data Source: HPRD (in vitro, in vivo)

		COPG2	PTGES3
Name		coat protein complex I subunit gamma 2	prostaglandin E synthase 3
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle Growth Cone COPI-coated Vesicle Membrane Cytoplasmic Vesicle Bounding Membrane Of Organelle	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytoplasm Cytosol Protein-containing Complex Protein Folding Chaperone Complex
	Molecular Function	Structural Molecule Activity	Telomerase Activity Protein Binding Isomerase Activity Prostaglandin-E Synthase Activity Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Secretion Protein Transport Vesicle-mediated Transport Organelle Transport Along Microtubule	Telomere Maintenance Prostaglandin Biosynthetic Process Protein Folding Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Telomere Maintenance Via Telomerase Signal Transduction Positive Regulation Of Telomere Maintenance Via Telomerase Prostanoid Biosynthetic Process Protein Stabilization Chaperone-mediated Protein Complex Assembly Telomerase Holoenzyme Complex Assembly
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS
Drugs		None	Acetaminophen Grn163l Copper
GWAS		A body shape index ( 34021172 ) Pancreatic cancer ( 25086665 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Alanine aminotransferase levels ( 33547301 ) Asthma ( 31619474 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Mean platelet volume ( 22139419 ) Platelet count ( 22139419 ) Reticulocyte count ( 32888494 )
Interacting Genes		12 interacting genes: ARCN1 ARL1 COPB1 COPE COPG1 COPZ1 COPZ2 DRD1 HES4 PTGES3 TAPBP TMED10	30 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSPA1A HSPB1 MAPT NR3C1 NR3C2 SIM2 STIP1 SURF1 TERT THRA
Entrez ID		26958	10728
HPRD ID		05074	06138
Ensembl ID		ENSG00000158623	ENSG00000110958
Uniprot IDs		A0A140VK12 Q9UBF2	A0A087WYT3 B3KUY2 Q15185
PDB IDs		Not available	1EJF 7KRJ 7L7I 7L7J
GO Terms Enriched among Interactors		COPI Vesicle Coat COPI-coated Vesicle Membrane Transport Vesicle Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Vesicle Transport Intra-Golgi Vesicle-mediated Transport Golgi Membrane COPI-coated Vesicle Intracellular Protein Transport Endoplasmic Reticulum Membrane Protein Transport Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Intracellular Protein Localization Cytoplasmic Vesicle Golgi Apparatus Membrane Coat Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Localization Protein Localization To Golgi Apparatus Structural Molecule Activity Cis-Golgi Network MHC Class Ib Protein Complex Assembly Peptide Antigen Stabilization Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Cerebellar Purkinje Cell Layer Maturation Phospholipase D Activator Activity Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G Protein-coupled Receptor Complex Tapasin-ERp57 Complex Adult Locomotory Behavior Secretory Granule Membrane Conditioned Taste Aversion Sensitization TAP2 Binding TAP Complex Binding Prostaglandin-E Synthase Activity Endoplasmic Reticulum Membrane Habituation Operant Conditioning Unfolded Protein Binding TAP1 Binding	Hsp90 Protein Binding Nuclear Receptor Activity TBP-class Protein Binding Unfolded Protein Binding Response To Temperature Stimulus Response To Heat Regulation Of Gene Expression Cellular Response To Heat Regulation Of Macromolecule Biosynthetic Process Response To Lipid Protein Folding Chaperone Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Complex Regulation Of Apoptotic Process Protein Folding Chaperone Complex Cytoplasm Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein Polymerization Response To Unfolded Protein Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Intracellular Signal Transduction Regulation Of Metabolic Process Cytosol Response To Stress Regulation Of Protein-containing Complex Assembly Estrogen Response Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Protein-folding Chaperone Binding Negative Regulation Of Inclusion Body Assembly Protein Folding Negative Regulation Of Biosynthetic Process Animal Organ Development Regulation Of Cellular Response To Heat Intracellular Receptor Signaling Pathway Nuclear Aryl Hydrocarbon Receptor Complex Neurofibrillary Tangle Assembly Protein-containing Complex Regulation Of Neuron Apoptotic Process Regulation Of Microtubule Polymerization Regulation Of Inclusion Body Assembly Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Response To Hormone Positive Regulation Of Metabolic Process Response To Hypoxia Sequence-specific DNA Binding Cellular Response To Oxygen-containing Compound DNA-binding Transcription Factor Activity