GDI2 and RAB2A

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		GDI2	RAB2A
Name		GDP dissociation inhibitor 2	RAB2A, member RAS oncogene family
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Vesicle Secretory Granule Lumen Azurophil Granule Lumen Synapse Extracellular Exosome	Golgi Membrane Autophagosome Membrane Acrosomal Vesicle Nucleus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Extracellular Exosome
	Molecular Function	RNA Binding GDP-dissociation Inhibitor Activity Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Negative Regulation Of Cilium Assembly Negative Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Localization	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Vesicle-mediated Transport Macroautophagy Autophagosome-lysosome Fusion
Pathways		Neutrophil degranulation RAB GEFs exchange GTP for GDP on RABs	Golgi Cisternae Pericentriolar Stack Reorganization RAB geranylgeranylation
GWAS		Blood protein levels ( 30072576 ) Cutaneous malignant melanoma ( 32341527 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Osteosarcoma ( 23727862 )	Aspartate aminotransferase levels ( 33547301 ) Autoimmune thyroid disease ( 32581359 ) Estimated glomerular filtration rate ( 31152163 ) Low density lipoprotein cholesterol levels ( 32154731 ) Neutrophil count ( 32888494 ) Systemic sclerosis ( 31672989 ) Total cholesterol levels ( 29083408 )
Interacting Genes		12 interacting genes: CEBPA GLRA2 HSPB1 LINC00632 LINC01554 OGT RAB11A RAB2A RAB4A RAB5A RAB8A RAB9A	29 interacting genes: BLZF1 CBFB CCDC125 CEBPA CFL2 FAM114A1 FAM114A2 FRMD1 GAA GAPDH GARIN4 GARIN6 GDI2 GOLGA2 GORASP2 HES6 ICA1 MAPK6 MAPKAPK3 OTOS PMAIP1 PRKCI RBSN RGS2 SGSM2 STAMBPL1 TBC1D25 TMEM70 TRIM7
Entrez ID		2665	5862
HPRD ID		02863	01539
Ensembl ID		ENSG00000057608	ENSG00000104388
Uniprot IDs		P50395 Q6IAT1	P61019
PDB IDs		Not available	1Z0A
GO Terms Enriched among Interactors		GDP Binding G Protein Activity GTPase Activity GTP Binding Phagocytic Vesicle Regulation Of Long-term Neuronal Synaptic Plasticity Protein Transport Receptor Localization To Synapse Protein Localization To Synapse Intracellular Protein Localization Regulation Of Neuronal Synaptic Plasticity Amyloid-beta Clearance By Transcytosis Establishment Of Protein Localization Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Plasma Membrane To Endosome Transport Establishment Of Protein Localization To Postsynaptic Membrane Phagocytic Vesicle Membrane Neurotransmitter Receptor Transport To Plasma Membrane HMG Box Domain Binding Protein Localization To Cell Junction Endosomal Transport Vesicle-mediated Transport In Synapse Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Recycling Endosome Membrane Melanosome Myosin V Binding Trans-Golgi Network Membrane Rab Protein Signal Transduction Transcytosis Vesicle-mediated Transport Intracellular Transport Recycling Endosome Endosome Amyloid-beta Clearance Membrane Fusion Protein Localization To Postsynaptic Membrane Cytoplasmic Vesicle Cytoplasmic Vesicle Membrane Protein Localization To Postsynapse Extracellular Exosome RNA Polymerase II-specific DNA-binding Transcription Factor Binding Modulation Of Chemical Synaptic Transmission Vesicle Docking Involved In Exocytosis Regulation Of Synaptic Plasticity Cellular Localization Establishment Of Localization In Cell Macrophage Differentiation	None