BLOC1S1 and BLOC1S3

Number of citations: 0 (PubMedID 15102850)
Data Source: HPRD (in vivo, two hybrid)

		BLOC1S1	BLOC1S3
Name		biogenesis of lysosomal organelles complex 1 subunit 1	biogenesis of lysosomal organelles complex 1 subunit 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Lysosome Lysosomal Membrane Early Endosome Cytosol Membrane BLOC-1 Complex Cytoplasmic Side Of Lysosomal Membrane BORC Complex Axon Cytoplasm	Cytoplasm Cytosol Transport Vesicle BLOC-1 Complex Axon Cytoplasm
	Molecular Function	Protein Binding Transferase Activity Protein-lysine-acetyltransferase Activity	Protein Binding Protein Transmembrane Transporter Activity
	Biological Process	Anterograde Axonal Transport Aerobic Respiration Endosomal Transport Peptidyl-lysine Acetylation Neuron Projection Development Lysosome Localization Melanosome Organization Anterograde Synaptic Vesicle Transport Regulation Of Endosome Size Platelet Dense Granule Organization Regulation Of Lysosome Size Organelle Transport Along Microtubule	Eye Development Blood Coagulation Anterograde Axonal Transport Response To Xenobiotic Stimulus Platelet Activation Neuron Projection Development Melanosome Transport Melanosome Organization Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Endosome To Melanosome Transport Pigmentation Developmental Pigmentation Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Protein Transmembrane Transport
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Golgi Associated Vesicle Biogenesis
Diseases		None	Hermansky-Pudlak syndrome (HPS)
GWAS		Refractive error ( 32231278 )	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Quantitative traits ( 19197348 )
Interacting Genes		18 interacting genes: APP BLOC1S2 BLOC1S3 BLOC1S4 BLOC1S5 BLOC1S6 DCTN2 FBXO44 HGS MAGEB4 MTA1 NOTCH1 PBX2 PELP1 PTN SNAPC5 SNAPIN USHBP1	2 interacting genes: BLOC1S1 BLOC1S2
Entrez ID		2647	388552
HPRD ID		03263	12527
Ensembl ID		ENSG00000135441	ENSG00000189114
Uniprot IDs		P78537	Q6QNY0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Anterograde Synaptic Vesicle Transport BLOC-1 Complex Axo-dendritic Transport Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Anterograde Axonal Transport Vesicle Transport Along Microtubule Establishment Of Vesicle Localization Vesicle Cytoskeletal Trafficking Vesicle Localization Axon Cytoplasm Axonal Transport Organelle Transport Along Microtubule Transport Along Microtubule Neuron Projection Development Cytoskeleton-dependent Intracellular Transport Microtubule-based Transport Establishment Of Organelle Localization Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Pigment Granule Localization Vesicle Organization Plasma Membrane Bounded Cell Projection Organization Microtubule-based Movement Microvesicle Endosome To Melanosome Transport Organelle Localization Cell Projection Organization Microtubule-based Process Cellular Localization Establishment Of Localization In Cell Intracellular Transport Secretion Of Lysosomal Enzymes Pigmentation Positive Regulation Of Pigment Cell Differentiation Regulation Of Lysosome Size BORC Complex Positive Regulation Of Developmental Pigmentation Regulation Of Endosome Size Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Stem Cell Differentiation Cytoplasmic Side Of Lysosomal Membrane Regulation Of Developmental Pigmentation Developmental Pigmentation Chromatin Binding Rhythmic Process Regulation Of Vesicle Size	Anterograde Synaptic Vesicle Transport BLOC-1 Complex Platelet Dense Granule Organization Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Vesicle Transport Along Microtubule Anterograde Axonal Transport Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Secretory Granule Organization Axo-dendritic Transport Organelle Transport Along Microtubule Establishment Of Vesicle Localization Vesicle Localization Regulation Of Lysosome Size BORC Complex Transport Along Microtubule Regulation Of Endosome Size Cytoskeleton-dependent Intracellular Transport Cytoplasmic Side Of Lysosomal Membrane Microtubule-based Transport Regulation Of Vesicle Size Establishment Of Organelle Localization Vesicle Organization Microtubule-based Movement Organelle Localization Neuron Projection Development Lysosome Localization Microtubule-based Process Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Intracellular Transport Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Cellular Component Size Cellular Localization Endosomal Transport Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Glutamate Secretion, Neurotransmission Establishment Of Localization In Cell Regulation Of Glutamate Secretion, Neurotransmission Lysosomal Membrane Negative Regulation Of Dendritic Spine Development Mitochondrial Outer Membrane Permeabilization Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Glutamate Secretion Gamma-tubulin Complex Peptidyl-lysine Acetylation Asymmetric Synapse