FGF21 and MAPK7

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		FGF21	MAPK7
Name		fibroblast growth factor 21	mitogen-activated protein kinase 7
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Enzyme Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Low-density Lipoprotein Particle Clearance Neurogenesis Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Positive Regulation Of D-glucose Import Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	MAPK Cascade Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell Differentiation Calcineurin-NFAT Signaling Cascade Cellular Response To Stress Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Intracellular Signaling Cassette Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Cellular hexose transport Assembly of active LPL and LIPC lipase complexes	ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling
Drugs		None	Acetylsalicylic acid Minocycline Colforsin Fostamatinib
GWAS		Bipolar disorder ( 21926972 ) Breakfast cereal skipping frequency ( 31190057 ) Breakfast skipping ( 31190057 ) Cooked vegetable consumption ( 32066663 ) Dietary macronutrient intake ( 23372041 23636237 29988085 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) Meat-related diet ( 32066663 ) Non-oily fish consumption ( 32066663 ) Oily fish consumption ( 32066663 ) Pancreas volume ( 34128465 ) Pork consumption ( 32066663 ) Processed meat consumption ( 32066663 ) Relative carbohydrate intake ( 32393786 ) Relative protein intake ( 32393786 ) Relative sugar intake ( 32393786 ) Resting metabolic rate ( 28476931 ) Retinal vascular caliber ( 21060863 ) Triglyceride levels ( 32154731 32203549 ) Triglycerides ( 30275531 ) Urinary sodium excretion ( 31409800 )	Alzheimer's disease ( 30636644 )
Interacting Genes		9 interacting genes: CDC25A CDH7 KLB MAPK7 NEDD4 SGTA SGTB TNS2 YPEL3	31 interacting genes: ACTN4 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FOS FXR1 GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED10P ZKSCAN1
Entrez ID		26291	5598
HPRD ID		09447	03952
Ensembl ID		ENSG00000105550	ENSG00000166484
Uniprot IDs		Q9NSA1	Q13164
PDB IDs		5VAQ 6M6E 6M6F	2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN 7PUS
GO Terms Enriched among Interactors		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Targeting Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Establishment Of Protein Localization To Organelle Formation Of Structure Involved In A Symbiotic Process Protein Targeting To Membrane	Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Sequence-specific DNA Binding Regulation Of Cell Migration RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Transcription MAPK Cascade Regulation Of Cell Motility Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of MiRNA Metabolic Process Regulation Of Locomotion DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II ERK5 Cascade Positive Regulation Of Multicellular Organismal Process Positive Regulation Of MiRNA Transcription Signal Transduction Histone Deacetylase Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of MiRNA Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Regulation Of Primary Metabolic Process Regulation Of Apoptotic Process