AK5 and TRIM46

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		AK5	TRIM46
Name		adenylate kinase 5	tripartite motif containing 46
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Centriolar Satellite	Cytoplasm Cytoskeleton Axon Cell Projection Axon Initial Segment Main Axon Axon Cytoplasm Proximal Neuron Projection
	Molecular Function	Nucleotide Binding AMP Kinase Activity Nucleoside Diphosphate Kinase Activity ATP Binding Kinase Activity Transferase Activity Nucleobase-containing Compound Kinase Activity	Zinc Ion Binding Metal Ion Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process ADP Biosynthetic Process DADP Biosynthetic Process Pyrimidine Ribonucleotide Biosynthetic Process ATP Metabolic Process Nucleoside Monophosphate Phosphorylation	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Neuron Migration Axonogenesis Negative Regulation Of Axon Extension Regulation Of Protein Localization Anterograde Synaptic Vesicle Transport Protein Localization To Axon Positive Regulation Of Anterograde Dense Core Granule Transport
Pathways		Interconversion of nucleotide di- and triphosphates	Interferon gamma signaling
GWAS		Body mass index ( 25673413 ) Chronotype ( 26955885 27494321 30696823 ) Eosinophil percentage of white cells ( 27863252 ) Estimated glomerular filtration rate ( 31152163 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Household income (MTAG) ( 31844048 ) Immature fraction of reticulocytes ( 32888494 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Mean reticulocyte volume ( 32888494 ) Morning person ( 30696823 ) Morning vs. evening chronotype ( 27494321 26955885 26835600 ) Sleep traits (multi-trait analysis) ( 27992416 ) Type 2 diabetes (age of onset) ( 28060188 ) Urinary albumin excretion ( 30220432 ) Urinary albumin-to-creatinine ratio ( 31630189 )	Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Breast cancer ( 29059683 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Estimated glomerular filtration rate ( 31152163 ) Inflammatory bowel disease ( 28067908 ) Microalbuminuria ( 31511532 ) Serum CC16 levels ( 32839289 ) Serum uric acid levels ( 30993211 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Urate levels ( 31578528 31985003 23263486 ) Urinary albumin-to-creatinine ratio ( 31511532 ) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737 )
Interacting Genes		7 interacting genes: CPNE6 INTS15 NUCKS1 RNF114 STRN4 TRIM46 UGDH	20 interacting genes: AK5 APP BRCA1 CBLC MDM4 MTNR1B OTUD6A RNF125 RNF7 TK1 TRIM9 TSG101 UBE2D2 UBE2U UBE2Z UCHL5 USP1 USP15 USP2 USP32
Entrez ID		26289	80128
HPRD ID		10472	15563
Ensembl ID		ENSG00000154027	ENSG00000163462
Uniprot IDs		Q9Y6K8	A0A087WUH1 B7Z4F9 F5GYK0 Q7Z4K8
PDB IDs		2BWJ	Not available
GO Terms Enriched among Interactors		UDP-glucuronate Biosynthetic Process UDP-glucose 6-dehydrogenase Activity Gene Conversion Positive Regulation Of Anterograde Dense Core Granule Transport UDP-glucuronate Metabolic Process Proximal Neuron Projection	Post-translational Protein Modification Proteolysis Protein Modification Process Protein Metabolic Process Cysteine-type Deubiquitinase Activity Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cysteine-type Peptidase Activity Protein Ubiquitination Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Macromolecule Catabolic Process Ubiquitin Protein Ligase Activity Transferase Activity Ubiquitin Conjugating Enzyme Activity Protein K27-linked Deubiquitination Ubiquitin-protein Transferase Activity Peptidase Activity Protein Polyubiquitination Regulation Of Signal Transduction Ubiquitin-modified Histone Reader Activity Monoubiquitinated Protein Deubiquitination Cysteine-type Endopeptidase Activity Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Catabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RIG-I Signaling Pathway Regulation Of Cellular Response To Stress Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA Repair Negative Regulation Of ERBB Signaling Pathway Regulation Of Apoptotic Process Regulation Of Protein Stability Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Pyrimidine-containing Compound Biosynthetic Process Positive Regulation Of Error-prone Translesion Synthesis DADP Biosynthetic Process