AK5 and NUCKS1

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		AK5	NUCKS1
Name		adenylate kinase 5	nuclear casein kinase and cyclin dependent kinase substrate 1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Centriolar Satellite	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm
	Molecular Function	Nucleotide Binding AMP Kinase Activity Nucleoside Diphosphate Kinase Activity ATP Binding Kinase Activity Transferase Activity Nucleobase-containing Compound Kinase Activity	Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process ADP Biosynthetic Process DADP Biosynthetic Process Pyrimidine Ribonucleotide Biosynthetic Process ATP Metabolic Process Nucleoside Monophosphate Phosphorylation	Double-strand Break Repair Via Homologous Recombination Intracellular Glucose Homeostasis Regulation Of DNA Replication DNA Repair Chromatin Organization DNA Damage Response Replication Fork Processing Gene Conversion Interstrand Cross-link Repair Glucose Homeostasis Host-mediated Activation Of Viral Transcription Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Regulation Of DNA Strand Elongation Cellular Response To X-ray
Pathways		Interconversion of nucleotide di- and triphosphates	None
GWAS		Body mass index ( 25673413 ) Chronotype ( 26955885 27494321 30696823 ) Eosinophil percentage of white cells ( 27863252 ) Estimated glomerular filtration rate ( 31152163 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Household income (MTAG) ( 31844048 ) Immature fraction of reticulocytes ( 32888494 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Mean reticulocyte volume ( 32888494 ) Morning person ( 30696823 ) Morning vs. evening chronotype ( 27494321 26955885 26835600 ) Sleep traits (multi-trait analysis) ( 27992416 ) Type 2 diabetes (age of onset) ( 28060188 ) Urinary albumin excretion ( 30220432 ) Urinary albumin-to-creatinine ratio ( 31630189 )	Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 29892015 30061737 ) Body mass index ( 28892062 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Free thyroxine concentration ( 30367059 ) HDL cholesterol levels ( 32203549 ) Menarche (age at onset) ( 25231870 ) Parkinson's disease ( 19915576 32201043 28892059 27182965 25064009 19915575 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Posterior thalamic nuclei volume ( 34006833 ) Prostate-specific antigen levels ( 25434496 23269536 ) Pubertal anthropometrics ( 23449627 ) QT interval ( 24952745 ) Serum alkaline phosphatase levels ( 33547301 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Weight ( 28552196 )
Interacting Genes		7 interacting genes: CPNE6 INTS15 NUCKS1 RNF114 STRN4 TRIM46 UGDH	6 interacting genes: AK5 CEBPA DOCK9 GLP1R MDM2 RAD51AP1
Entrez ID		26289	64710
HPRD ID		10472	11406
Ensembl ID		ENSG00000154027	ENSG00000069275
Uniprot IDs		Q9Y6K8	Q9H1E3
PDB IDs		2BWJ	Not available
GO Terms Enriched among Interactors		UDP-glucuronate Biosynthetic Process UDP-glucose 6-dehydrogenase Activity Gene Conversion Positive Regulation Of Anterograde Dense Core Granule Transport UDP-glucuronate Metabolic Process Proximal Neuron Projection	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Vitamin RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 C/EBP Complex Response To Hormone Positive Regulation Of Proteasomal Protein Catabolic Process Glucagon-like Peptide 1 Receptor Activity Glucagon Receptor Activity Response To Vitamin B1 Response To Water-immersion Restraint Stress Cellular Response To Ionizing Radiation Response To Formaldehyde Cellular Response To Vitamin B1 Response To Ionizing Radiation Cellular Response To Actinomycin D Centriolar Satellite D-loop DNA Binding Positive Regulation Of Reciprocal Meiotic Recombination DADP Biosynthetic Process Response To Nutrient Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Psychosocial Stress Cellular Response To Peptide Hormone Stimulus NEDD8 Ligase Activity Response To Actinomycin D Cellular Response To Radiation Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To UV-C Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission DNA Secondary Structure Binding ADP Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Heart Contraction Receptor Serine/threonine Kinase Binding Positive Regulation Of Protein Catabolic Process Response To Steroid Hormone Response To Phenylpropanoid Protein Domain Specific Binding Fat Cell Proliferation Post-translational Protein Targeting To Membrane, Translocation