FBXO25 and TNIP2

Number of citations: 41 (PubMedID 23940030)
Data Source: BioGRID (enzymatic study)

		FBXO25	TNIP2
Name		F-box protein 25	TNFAIP3 interacting protein 2
Structure		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	Protein Binding Zinc Ion Binding Protein Kinase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Protein Ubiquitination	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response CD40 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Macrophage Activation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of B Cell Activation Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		None	MAP3K8 (TPL2)-dependent MAPK1/3 activation Ovarian tumor domain proteases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952 ) Nontraumatic osteonecrosis of the femoral head ( 32701715 )	Extrinsic epigenetic age acceleration ( 29374233 ) Multiple sclerosis ( 31604244 ) Systemic lupus erythematosus ( 33536424 )
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	28 interacting genes: APP BACE1 CACNA1C CDKN1A CLK1 EP300 FBXO25 FLNA FXR2 IKBKG MAP3K8 MAPK1 MKNK1 NCOR2 NFKB1 NFKB2 PSMD9 REL RELA SHANK3 SMARCD1 SMURF1 SRPK2 STK11 TEK TNFAIP3 TSG101 UBC
Entrez ID		26260	79155
HPRD ID		16439	18207
Ensembl ID		ENSG00000147364	ENSG00000168884
Uniprot IDs		Q8TCJ0	D6RGJ2 Q8NFZ5
PDB IDs		Not available	5H07
GO Terms Enriched among Interactors		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Intracellular Signaling Cassette Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Protein Metabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Primary Metabolic Process Cytosol NF-kappaB P50/p65 Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Inflammatory Response Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Protein Serine/threonine Kinase Binding Signal Transduction Response To UV-B Positive Regulation Of Cell Development Immune Response-regulating Cell Surface Receptor Signaling Pathway I-kappaB/NF-kappaB Complex Positive Regulation Of Defense Response Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cell Differentiation Nucleus Response To Lipopolysaccharide Negative Regulation Of MiRNA Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process NF-kappaB Complex Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Response To Molecule Of Bacterial Origin Response To Mechanical Stimulus Protein Serine Kinase Activity Response To Cytokine Regulation Of Immune System Process Regulation Of Gene Expression Response To Peptide Positive Regulation Of Neurogenesis