FBXO25 and HP1BP3

Number of citations: 41 (PubMedID 23940030)
Data Source: BioGRID (enzymatic study)

		FBXO25	HP1BP3
Name		F-box protein 25	heterochromatin protein 1 binding protein 3
Structure		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex	Nucleosome Nucleus Chromosome Nuclear Speck
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding	DNA Binding Protein Binding Nucleosome Binding
	Biological Process	Protein Ubiquitination	Nucleosome Assembly Regulation Of DNA-templated Transcription Regulation Of Cell Population Proliferation Heterochromatin Organization Cellular Response To Hypoxia Regulation Of Nucleus Size
Drugs		None	Artenimol
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952 ) Nontraumatic osteonecrosis of the femoral head ( 32701715 )	Adventurousness ( 30643258 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Morning person ( 30696823 ) Physical activity (walking duration) ( 30531941 )
Interacting Genes		82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1	6 interacting genes: APP FBXO25 MEOX2 OGT SLC26A4-AS1 SUMO2
Entrez ID		26260	50809
HPRD ID		16439	11026
Ensembl ID		ENSG00000147364	ENSG00000127483
Uniprot IDs		Q8TCJ0	Q5SSJ5
PDB IDs		Not available	2RQP
GO Terms Enriched among Interactors		Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly	Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Regulation Of Synapse Assembly Positive Regulation Of RNA Biosynthetic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Hemopoiesis Positive Regulation Of RNA Metabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Positive Regulation Of DNA-templated Transcription Low-density Lipoprotein Particle Mediated Signaling Somite Specification Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Spontaneous Synaptic Transmission