ARL5A and CBX3

Number of citations: 0 (PubMedID 12414990)
Data Source: BioGRID (two hybrid)

		ARL5A	CBX3
Name		ARF like GTPase 5A	chromobox 3
Structure
GO Annotations	Cellular Component	Cytoplasm Trans-Golgi Network	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus Chromatin Lock Complex RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage
	Molecular Function	Nucleotide Binding GTPase Activity GTP Binding	Transcription Coregulator Binding Chromatin Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport Protein Localization To Golgi Membrane	Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Dexamethasone Stimulus
Pathways		None	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs		Guanosine-5'-Diphosphate	None
GWAS		Response to cognitive-behavioural therapy in anxiety disorder ( 26989097 )	Metabolite levels ( 23823483 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		6 interacting genes: APP CBX1 CBX3 CBX5 KPNA2 NMT1	42 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LIG1 MGA MIS12 MKI67 MRPL12 NSD3 PIM1 RAD54L2 SP100 STK16 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280D ZNF496
Entrez ID		26225	11335
HPRD ID		12343	05130
Ensembl ID		ENSG00000162980	ENSG00000122565
Uniprot IDs		Q9Y689	A4D177 B8ZZ43 Q13185
PDB IDs		1Z6Y 1ZJ6 2H16 2H17	2L11 3DM1 3KUP 3TZD 5T1I 6HW2 8JZW
GO Terms Enriched among Interactors		Pericentric Heterochromatin Site Of DNA Damage Heterochromatin Epigenetic Regulation Of Gene Expression Chromocenter Chromatin Binding Heterochromatin Formation Histone Methyltransferase Binding Chromosome, Centromeric Region Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Chromatin Remodeling Chromatin Organization Amyloid-beta Complex Growth Cone Lamellipodium Negative Regulation Of Gene Expression Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Myristoyltransferase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production Negative Regulation Of RNA Metabolic Process Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Histone Deacetylase Binding Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Glycylpeptide N-tetradecanoyltransferase Activity Peptidyl-lysine N6-myristoyltransferase Activity N-terminal Peptidyl-glycine N-myristoylation Chromatin Lock Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response	Chromatin Remodeling Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process DNA Binding Heterochromatin Regulation Of Mitotic Cell Cycle Chromo Shadow Domain Binding Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Chromocenter Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Nuclear Division Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Regulation Of Nuclear Division Nuclear Body Regulation Of Cell Cycle Spindle Midzone MIS12/MIND Type Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Kinetochore Chromosome, Centromeric Region Regulation Of Cell Cycle Process Structural Constituent Of Chromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Protein-containing Complex Chromosome Passenger Complex Attachment Of Spindle Microtubules To Kinetochore Protein-DNA Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleosome Assembly Negative Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process