PTPN22 and CD247

Number of citations: 0 (PubMedID 16461343)
Data Source: HPRD (in vivo)

		PTPN22	CD247
Name		protein tyrosine phosphatase non-receptor type 22	CD247 molecule
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Fc-gamma Receptor III Complex T Cell Receptor Complex Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Plasma Membrane Protein Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Tyrosine Kinase Binding
	Biological Process	Immune System Process Lipid Metabolic Process Autophagy Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphoanandamide Dephosphorylation Negative Regulation Of JUN Kinase Activity Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Muramyl Dipeptide Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of P38MAPK Cascade	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein Complex Oligomerization Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse	None
Drugs		None	Muromonab Teclistamab Odronextamab
Diseases		Type I diabetes mellitus	None
GWAS		Alopecia areata ( 25608926 ) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 ) Arthritis (juvenile idiopathic) ( 33106285 ) Autoimmune thyroid disease ( 32581359 ) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229 ) Autoimmune traits (pleiotropy) ( 30572963 ) Breast cancer ( 23535729 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 18587394 21102463 28067908 23128233 ) Giant cell arteritis ( 25817017 ) Granulocyte count ( 27863252 ) Graves' disease ( 22922229 ) Gut microbiota (bacterial taxa) ( 27694959 ) Hashimoto thyroiditis ( 22922229 ) Hodgkin's lymphoma ( 30194254 ) Hypothyroidism ( 22493691 27182965 ) Idiopathic inflammatory myopathy ( 26362759 ) IgM levels ( 28628107 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Late-onset myasthenia gravis ( 26562150 ) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083 ) Lymphocyte count ( 27863252 32888494 ) Medication use (drugs used in diabetes) ( 31015401 ) Medication use (thyroid preparations) ( 31015401 ) Myasthenia gravis ( 23055271 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 ) Obesity-related traits ( 23251661 ) Pediatric autoimmune diseases ( 26301688 ) Polymyositis ( 26362759 ) Rheumatoid arthritis ( 30423114 30572963 30891314 17554300 17804836 18794853 19503088 21156761 24449572 24390342 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Severe autoimmune type 2 diabetes ( 34737425 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Systemic lupus erythematosus ( 28714469 19838195 26502338 27399966 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 ) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655 ) Thyroid peroxidase antibody levels ( 24586183 ) Type 1 diabetes ( 21829393 17554260 17554300 17632545 25751624 19430480 30572963 18978792 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926 ) Vitiligo ( 27723757 20410501 ) White blood cell count ( 32888494 27863252 )	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011 ) Allergic rhinitis ( 31361310 ) Asthma ( 34103634 31361310 31619474 31959851 32296059 30929738 27182965 ) Asthma (adult onset) ( 30929738 ) Asthma (childhood onset) ( 30929738 ) Asthma (moderate or severe) ( 30552067 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Autoimmune thyroid disease ( 32581359 ) Celiac disease ( 20190752 ) Celiac disease or Rheumatoid arthritis ( 21383967 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Medication use (thyroid preparations) ( 31015401 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Systemic sclerosis ( 31672989 29293537 21779181 21750679 20383147 )
Interacting Genes		13 interacting genes: CBL CD247 CD3E CLK1 CRK CSK EGFR GRB2 LCK PRKCD SRPK2 VAV1 ZAP70	38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		26191	919
HPRD ID		06100	01729
Ensembl ID		ENSG00000134242	ENSG00000198821
Uniprot IDs		B4DZW8 F5H2S8 G3K0T4 Q9Y2R2	A0A8V8TPP4 A0A8V8TQM0 P20963 Q6KAV0
PDB IDs		2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51 7AAM	1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8J8I 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
GO Terms Enriched among Interactors		Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade T Cell Costimulation Cell-cell Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Lymphocyte Activation Fc-gamma Receptor Signaling Pathway Immune System Process Leukocyte Activation Protein Tyrosine Kinase Binding T Cell Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of T Cell Activation Fc Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Positive Regulation Of Cell Adhesion T Cell Activation Protein Kinase Activity Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion T Cell Receptor Complex Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Gamma-delta T Cell Activation Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Positive Regulation Of Signal Transduction Kinase Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Protein Phosphatase Binding Regulation Of Cell Activation Gamma-delta T Cell Receptor Complex Ephrin Receptor Binding	Lymphocyte Activation Immune System Process Leukocyte Activation Cell Activation Signal Transduction Positive Regulation Of Immune System Process Natural Killer Cell Activation T Cell Activation Regulation Of Lymphocyte Activation Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Plasma Membrane T Cell Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Lymphocyte Mediated Immunity Positive Regulation Of Cell-cell Adhesion Leukocyte Mediated Cytotoxicity T Cell Costimulation Phosphotyrosine Residue Binding Regulation Of T Cell Receptor Signaling Pathway Leukocyte Mediated Immunity Immune Effector Process Positive Regulation Of Cell Adhesion Adaptive Immune Response Regulation Of Mononuclear Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Leukocyte Proliferation Regulation Of Lymphocyte Mediated Immunity T Cell Receptor Complex Natural Killer Cell Mediated Immunity Alpha-beta T Cell Receptor Complex