RAI14 and YWHAB

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology), HPRD (in vivo)

		RAI14	YWHAB
Name		retinoic acid induced 14	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Structure		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cell Cortex Anchoring Junction	Nucleus Cytoplasm Vacuole Vacuolar Membrane Cytosol Focal Adhesion Membrane Transcription Repressor Complex Protein-containing Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding	Protein Kinase Inhibitor Activity Protein Phosphatase Inhibitor Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Deacetylase Binding Protein-containing Complex Binding Cadherin Binding Phosphoserine Residue Binding Phosphoprotein Binding Protein Sequestering Activity
	Biological Process	Spermatogenesis Cell Differentiation	Protein Targeting Signal Transduction Intracellular Protein Localization Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		None	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane MTOR signalling mTORC1-mediated signalling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signaling by Hippo Rap1 signalling Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA RHO GTPases activate PKNs TP53 Regulates Metabolic Genes RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		None	Copper Phenethyl Isothiocyanate
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325 ) Blood urea nitrogen levels ( 31152163 ) Chronic kidney disease ( 31152163 ) Creatinine levels ( 29403010 ) Daytime sleep phenotypes ( 27126917 ) Estimated glomerular filtration rate ( 31152163 31451708 31015462 30604766 ) Estimated glomerular filtration rate in diabetes ( 31451708 ) Glomerular filtration rate ( 29403010 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) LDL cholesterol levels ( 32203549 ) Left ventricular mass ( 19454037 ) Platelet count ( 32888494 ) Red blood cell count ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum uric acid levels ( 30993211 ) Urate levels ( 31578528 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 )	Basophil count ( 32888494 ) Basophil percentage of white cells ( 32888494 ) Blood protein levels ( 30072576 ) Breakfast cereal skipping frequency ( 31190057 ) Breakfast skipping ( 31190057 ) Mean platelet volume ( 32888494 )
Interacting Genes		8 interacting genes: FEZ1 FEZ2 ITSN1 TTC3 USP7 YWHAB YWHAG YWHAQ	147 interacting genes: ABL1 ADAM22 AFDN AKAP13 ALS2 APP ATP5F1A BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DHX15 DYRK1A EDC3 EGFR EPB41 EPB41L1 EPB41L3 ERRFI1 EXO1 FER FILNC1 FRMD6 GAPVD1 GEM H3C1 HDAC5 HES1 HSP90AB1 HSPA1A HSPA1B HSPA5 HSPB1 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLXIP MPRIP MST1R MTNR1A MTNR1B NCAM2 NEDD4L OSBPL3 PARD3 PARD6B PDCL2 PDE3B PDE4B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RIPK2 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1
Entrez ID		26064	7529
HPRD ID		09416	03184
Ensembl ID		ENSG00000039560	ENSG00000166913
Uniprot IDs		Q9P0K7	P31946 V9HWD6
PDB IDs		Not available	2BQ0 2C23 4DNK 5N10 6A5Q 6BYK 6GN0 6GN8 6GNJ 6GNK 6GNN 6HEP 8DP5 8EQ8 8EQH
GO Terms Enriched among Interactors		Negative Regulation Of Autophagy Negative Regulation Of Autophagosome Assembly Protein Domain Specific Binding Protein Targeting Regulation Of Intracellular Transport Protein Sequestering Activity Protein Kinase C Binding Negative Regulation Of Macroautophagy Regulation Of Autophagosome Assembly Regulation Of Transport Negative Regulation Of Metabolic Process Negative Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Vacuole Organization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Negative Regulation Of Catabolic Process Regulation Of Autophagy TOR Signaling Cytoplasm Focal Adhesion Negative Regulation Of TOR Signaling Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of TORC1 Signaling Regulation Of Cellular Localization Protein Kinase C Inhibitor Activity Symbiont-mediated Disruption Of Host Cell PML Body Establishment Of Protein Localization Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of TOR Signaling Protein Ubiquitination Phosphoserine Residue Binding Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Caveolin-mediated Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Protein Modification By Small Protein Conjugation Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of Macroautophagy Postsynaptic Endocytic Zone Signal Transduction Positive Regulation Of Growth Hormone Secretion Protein-containing Complex Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Monoubiquitinated Protein Deubiquitination Regulation Of Organelle Transport Along Microtubule Axon Guidance Neuron Projection Guidance Postsynaptic Actin Cytoskeleton Phosphorylation-dependent Protein Binding Protein Stabilization	Kinase Activity Protein Kinase Activity Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cytosol Protein Serine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Cell Communication Cytoplasm Protein Phosphorylation ATP Binding Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Nucleotide Binding Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Signal Transduction Cellular Response To Oxygen-containing Compound Protein Tyrosine Kinase Activity Response To Stress Cellular Response To Stress Regulation Of Cell Cycle Regulation Of Membrane Potential Intracellular Signaling Cassette Cellular Response To Hormone Stimulus Cadherin Binding Regulation Of Protein-containing Complex Assembly Regulation Of Phosphorus Metabolic Process Cellular Response To Insulin Stimulus Regulation Of Protein Phosphorylation Regulation Of Biological Quality Plasma Membrane Response To Insulin Positive Regulation Of Catabolic Process Phosphate-containing Compound Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of Phosphorylation