NECAP1 and DAB2

Number of citations: 67 (PubMedID 17762867)
Data Source: HPRD (in vivo)

		NECAP1	DAB2
Name		NECAP endocytosis associated 1	DAB adaptor protein 2
Structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Vesicle Coat Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Presynapse	Fibrillar Center Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Endocytosis Protein Transport Vesicle-mediated Transport Presynaptic Endocytosis	Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Neuron Projection Development Protein Transport Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Clathrin Coat Assembly Response To Steroid Hormone Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Salt Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Aldosterone Secretion
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Gap junction degradation Formation of annular gap junctions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
GWAS		No GWAS studies recorded	Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 33547301 29403010 ) Birth weight ( 31043758 ) Chronic kidney disease ( 20383146 31152163 ) Creatinine levels ( 31015462 ) Diverticular disease ( 30177863 ) Estimated glomerular filtration rate ( 31451708 31152163 30604766 31015462 ) Estimated glomerular filtration rate in diabetes ( 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Glomerular filtration rate (creatinine) ( 28452372 26831199 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) HDL cholesterol levels ( 32203549 ) Health literacy ( 31250787 ) Heel bone mineral density ( 30598549 28869591 ) Height ( 31562340 ) Non-albumin protein levels ( 29403010 ) Pancreatic cancer ( 22158540 ) Premature menopause in childhood cancer survivors ( 29432556 ) Self-reported allergy ( 23817569 ) Systemic lupus erythematosus ( 19838195 ) Urate levels ( 23263486 ) Waist-hip ratio ( 28552196 )
Interacting Genes		10 interacting genes: AMPH AP1B1 APP DAB2 DAPK1 DNAJC5 HIP1 REL SNAP91 SNCA	40 interacting genes: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 FCHO1 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 LRP8 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SGIP1 SMAD2 SMAD3 SMURF2 SRC SUMO2 TGFBR1 TGFBR2
Entrez ID		25977	1601
HPRD ID		14819	03139
Ensembl ID		ENSG00000089818	ENSG00000153071
Uniprot IDs		Q8NC96	B2RAW0 P98082
PDB IDs		6RH5 6RH6	2LSW 6O5O 6OVF
GO Terms Enriched among Interactors		Synaptic Vesicle Vesicle-mediated Transport Endocytosis Regulation Of Vesicle-mediated Transport Clathrin Coat Assembly Phospholipid Binding Import Into Cell Regulation Of Receptor-mediated Endocytosis Regulation Of Endocytosis Clathrin Binding Clathrin-coated Vesicle Membrane Positive Regulation Of Endocytosis Cytoplasmic Vesicle Apoptotic Process Positive Regulation Of Receptor-mediated Endocytosis Programmed Cell Death Cell Death Regulation Of Transport Presynapse Clathrin-coated Pit Clathrin-coated Vesicle Vesicle-mediated Transport In Synapse Clathrin Adaptor Activity Regulation Of Clathrin-dependent Endocytosis Regulation Of Apoptotic Process Synaptic Vesicle Membrane Regulation Of Neurotransmitter Uptake Regulation Of Programmed Cell Death Cellular Response To Copper Ion Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Positive Regulation Of Small Molecule Metabolic Process Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Receptor-mediated Endocytosis Amyloid Fibril Formation Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Synaptic Vesicle Exocytosis Response To Copper Ion Response To Cytokine Positive Regulation Of Catabolic Process Response To Peptide Synaptic Vesicle Endocytosis Postsynapse Presynaptic Endocytosis Regulation Of Neuron Apoptotic Process Protein-containing Complex Assembly Actin Cytoskeleton	Clathrin-coated Pit Endocytosis Import Into Cell Plasma Membrane Cell Surface Receptor Signaling Pathway Anatomical Structure Morphogenesis Receptor Complex Signal Transduction Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Receptor-mediated Endocytosis Vesicle-mediated Transport Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Signaling Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Developmental Process Response To Growth Factor Regulation Of Cell Communication Clathrin-dependent Endocytosis Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tube Morphogenesis Positive Regulation Of Protein Catabolic Process Regulation Of Transport Low-density Lipoprotein Particle Receptor Activity Membrane I-SMAD Binding Cellular Response To Oxygen-containing Compound Presynaptic Endocytosis Regulation Of Cellular Response To Growth Factor Stimulus Vesicle-mediated Transport In Synapse Regulation Of Protein Localization Immune Response-activating Cell Surface Receptor Signaling Pathway SMAD Binding Cytosol Positive Regulation Of Lysosomal Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Neuron Projection Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Cell Projection Morphogenesis