CCDC28A and ICA1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		CCDC28A	ICA1
Name		coiled-coil domain containing 28A	islet cell autoantigen 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	None	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Endomembrane System Membrane Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse
	Molecular Function	Protein Binding	Protein Binding Protein Domain Specific Binding Membrane Curvature Sensor Activity
	Biological Process	None	Neurotransmitter Transport Regulation Of Secretion Membrane Bending
GWAS		No GWAS studies recorded	Cognitive function ( 24684796 ) Intraocular pressure ( 23836780 ) Metabolite levels (Pyroglutamine) ( 23934736 ) Night sleep phenotypes ( 27126917 ) Obesity-related traits ( 23251661 ) Systemic lupus erythematosus ( 28714469 )
Interacting Genes		9 interacting genes: DYNLL1 ICA1 IGFBP6 KIFC3 KRTAP9-2 MYOG SRPK2 TRIM54 USHBP1	9 interacting genes: CCDC28A EXOC5 ING5 MBD3 RAB2A RAB2B SHANK3 SNCA TSC1
Entrez ID		25901	3382
HPRD ID		09857	00971
Ensembl ID		ENSG00000024862	ENSG00000003147
Uniprot IDs		B4DUJ5 Q8IWP9	A0A024RA29 Q05084
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Autophagosome Membrane Response To Desipramine Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Adult Behavior Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Hsp70 Protein Binding Synapse Organization Memory T Cell Differentiation Acrosomal Vesicle Negative Regulation Of Serotonin Uptake Positive Regulation Of Exocytosis Adult Locomotory Behavior Transporter Regulator Activity Regulation Of Norepinephrine Uptake Regulation Of Supramolecular Fiber Organization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Autophagy Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Chaperone-mediated Autophagy Cell Junction Organization Regulation Of Cell Size TSC1-TSC2 Complex Associative Learning DNA Replication-dependent Chromatin Disassembly Guanylate Kinase-associated Protein Clustering Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Golgi Organization Vesicle-mediated Transport Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Synaptic Receptor Adaptor Activity Regulation Of Cytoskeleton Organization Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Synaptic Transmission ATPase Inhibitor Activity Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Macroautophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Learning Response To Bisphenol A