PRKD2 and RRBP1

Number of citations: 54 (PubMedID 15231748)
Data Source: BioGRID (two hybrid)

		PRKD2	RRBP1
Name		protein kinase D2	ribosome binding protein 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Ribosome Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	RNA Binding Protein Binding Signaling Receptor Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Immune System Process Protein Phosphorylation Cell Adhesion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Sphingolipid Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-8 Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Endothelial Tube Morphogenesis Regulation Of T Cell Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis	Osteoblast Differentiation Translation Protein Transport
Pathways		Sphingolipid de novo biosynthesis	Signaling by ALK fusions and activated point mutants
Drugs		None	Radezolid
GWAS		Aspartate aminotransferase levels ( 33547301 ) Chronic lymphocytic leukemia ( 18758461 28165464 ) Coronary artery disease ( 29212778 ) Eosinophil count ( 32888494 ) Heel bone mineral density ( 30598549 ) Post bronchodilator FEV1 ( 26634245 ) Primary sclerosing cholangitis ( 23603763 27992413 )	Apolipoprotein A1 levels ( 32203549 ) Coronary artery disease ( 29212778 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Frontotemporal dementia (age at onset) ( 29724592 ) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592 ) HDL cholesterol levels ( 32203549 ) Height ( 31562340 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 )
Interacting Genes		17 interacting genes: CASK DST GORASP1 GRIP1 HDAC7 HEY1 IFNAR1 MTF2 PDLIM7 PFDN1 PSG3 RARB RRBP1 RXRA SNRNP70 TGOLN2 VPS26C	7 interacting genes: ATF7IP ITSN1 KIF5B PCNT PRKD2 RNF10 SMAD9
Entrez ID		25865	6238
HPRD ID		09523	11796
Ensembl ID		ENSG00000105287	ENSG00000125844
Uniprot IDs		Q9BZL6	Q9P2E9
PDB IDs		2COA 3BGM 4NNX 4NNY	Not available
GO Terms Enriched among Interactors		None	Regulation Of Modification Of Synaptic Structure Stress Granule Disassembly Anterograde Neuronal Dense Core Vesicle Transport Ciliary Rootlet Plus-end-directed Vesicle Transport Along Microtubule Positive Regulation Of Transport Centriolar Satellite Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Cytoplasm Organization Cytolytic Granule Membrane Retrograde Neuronal Dense Core Vesicle Transport Anterograde Axonal Protein Transport Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Plus-end-directed Organelle Transport Along Microtubule Mitocytosis Dense Core Granule Cytoskeletal Transport Positive Regulation Of RNA Metabolic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Molecular Adaptor Activity Postsynaptic Endocytic Zone Positive Regulation Of Caveolin-mediated Endocytosis Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway