FBXL2 and UBE2D3

Number of citations: 65 (PubMedID 34635651)
Data Source: BioGRID (pull down)

		FBXL2	UBE2D3
Name		F-box and leucine rich repeat protein 2	ubiquitin conjugating enzyme E2 D3
Structure
GO Annotations	Cellular Component	Cytoplasm Membrane SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Regulation Of Autophagy Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response Protein Modification Process Host-mediated Perturbation Of Viral RNA Genome Replication Regulation Of Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of NLRP3 Inflammasome Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process DNA Damage Response Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		None	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
GWAS		Heel bone mineral density ( 30598549 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Rostral anterior cingulate cortex volume ( 31530798 )	Alanine aminotransferase levels ( 33547301 ) Asthma and attention deficit hyperactivity disorder ( 31619474 ) Diastolic blood pressure ( 30224653 ) Shoulder impingement or rotator cuff tear ( 33482370 )
Interacting Genes		14 interacting genes: APP AURKB CCND2 CDC34 COL7A1 EGFR IL1B NLRP3 PIK3R2 RBX1 SKP1 UBE2D1 UBE2D3 UBE2G1	223 interacting genes: AMBRA1 AMFR ANAPC11 AREL1 ARIH1 ARIH2 ARK2C ATXN3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 CADPS2 CBL CBLC CHFR CNOT4 CRBN CSNK2A1 CUL2 CUL4B DBN1 DCAF1 DCUN1D1 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL12 FBXL2 FBXO2 FBXO25 FBXO4 FBXO7 FBXW10 FBXW11 FBXW8 FOCAD FZR1 H2AC4 HDAC6 HECTD1 HECTD3 HECW1 HECW2 HERC1 HERC2 HSP90AB1 HSPA1A IKBKG ITCH KAT2B KDM1B KLHL3 LRSAM1 MAEA MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEX3B MEX3C MGRN1 MIB1 MID1 MID2 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYCBP2 MYLIP NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 NOSIP OTUB1 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PCNA PDCD5 PELI1 PJA1 PJA2 POLL POLM PPP4C PRPF19 RABGEF1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RMND5B RNF103 RNF111 RNF113A RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF168 RNF181 RNF185 RNF19B RNF2 RNF213 RNF216 RNF220 RNF26 RNF31 RNF34 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RNFT1 RPLP1 RSPRY1 SAT1 SH3RF1 SIAH1 SIAH2 SMURF1 SMURF2 STAM2 STAU1 STK25 STUB1 SYVN1 TMEM129 TOPORS TRAF6 TRAIP TRIM10 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM62 TRIM63 TRIM68 TRIM69 TRIM7 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBC UBE2O UBE3A UBE3C UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF1 USP7 UVSSA VHL WSB1 WWP1 WWP2 XIAP XPNPEP1 ZNF598 ZNRF1 ZNRF2 ZNRF4
Entrez ID		25827	7323
HPRD ID		05736	04269
Ensembl ID		ENSG00000153558	ENSG00000109332
Uniprot IDs		B4E1B8 Q9UKC9	D6RAH7 P61077
PDB IDs		6O60	1X23 2FUH 3L1Z 3RPG 3UGB 4BVU 4R8P 4S3O 5EGG 5IFR 6CP0 6T7F 7JZV 7LYB 8AMS 8GRQ 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8X7I 8X7J 8X7K 9IPU
GO Terms Enriched among Interactors		Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of Mitotic Cell Cycle Protein Polyubiquitination Positive Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signaling Cytosol Negative Regulation Of Cell Communication Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Process Post-translational Protein Modification Cul7-RING Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ATP Binding Protein Catabolic Process Protein Ubiquitination Regulation Of Intracellular Signal Transduction Cell Cycle Phase Transition Regulation Of Cell Cycle Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Response To Radiation Negative Regulation Of Intracellular Signal Transduction Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Intracellular Signal Transduction G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Cellular Response To Oxygen-containing Compound Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Astrocyte Activation Positive Regulation Of Cell Cycle Checkpoint Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Signaling Response To Light Stimulus	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Catabolic Process Metal Ion Binding Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Ubiquitin Ligase Complex Cytoplasm Response To Stress Cellular Response To Stress Protein Monoubiquitination Regulation Of Signal Transduction Ubiquitin-ubiquitin Ligase Activity Regulation Of Signaling Regulation Of Post-translational Protein Modification Regulation Of Cell Communication Ubiquitin Protein Ligase Binding Positive Regulation Of Catabolic Process Ubiquitin Binding Cytosol Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction DNA Damage Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Immune System Process Negative Regulation Of Signaling